Translational Science at UVA focuses on transformative “bench-to-bedside” research accomplished through collaborations between basic and clinical scientists. The synergistic environment generated by the close proximity of the University and the Medical Center supports teams working together on research problems that have the potential for immediate and/or short-term impact on human health.
Students interested in a career in translational science pursue individualized training programs that include relevant seminar series and journal clubs that focus on medically-applicable research, along with coursework offerings from across several degree granting programs that provide instruction in clinical problems and basic science approaches to address them.
Students benefit from the collaborative environment with ready access to physicians who can offer a clinical perspective to their basic science training.
- Roger Abounader
Basic and translational brain tumor research
- Mazhar Adli
Understanding and manipulating the genetics and epigenetics information to study stem cells, differentiation and cancer
- Paula Q. Barrett
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
- Douglas A. Bayliss
Mechanisms of neuromodulation in central neurons
- Stefan Bekiranov
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
- Stuart S. Berr
Developing magnetic resonance (MR) techniques as a tool for basic biomedical research.
- Edward H. Bertram
Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
- Sanchita Bhatnagar
Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
- Michelle Bland
Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
- Amy H. Bouton
Signaling Pathways and Breast Cancer
- Timothy N. Bullock
Pathways to enhance T cell function in tumors.
- John H. Bushweller
Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
- Steven Caliari
Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
- Jessica J. Connelly
Epigenetic mechanisms involved in complex human disease
- Janet V. Cross
Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention; Anti-Inflammatory Benefits of Dietary Nutrient Compounds
- Daniel A. Engel
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
- Victor H. Engelhard
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
- Loren D. Erickson
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
- Salem Faham
Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
- Robin A. Felder
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
- Jay W. Fox
Basement Membrane Structure and Metalloproteinases
- Cassandra L. Fraser
Polymeric Metal Complexes. Metallobiomaterials for Medicine and Biotechnology. Bio-inspired and Sustainable Design. Responsive Nanoscale Assemblies.
- Brent A. French
Novel Therapies for Treating and Preventing Ischemic Heart Disease
- Ravi K Ghanta
Biotechnology, Translational Science
- George T. Gillies
Design of novel neurosurgical instrumentation systems, including magnetic stereotactic devices
- Adam N. Goldfarb
Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
- Michael J. Guertin
Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
- Jennifer Guler
Cell Biology and Parasitology.
- Thurl E Harris
Molecular mechanisms controlling insulin signaling and fat synthesis.
- John C. Herr
Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.
- Erik L. Hewlett
Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research
- Jeffrey W. Holmes
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
- Ku-Lung Hsu
Lipid Metabolism in Inflammation and Immunity
- Song Hu
Photoacoustic imaging, light microscopy, neuroscience, microvascular biology
- Brant Isakson
Intercellular communication as it relates to blood pressure regulation
- Jaideep Kapur
Pathophysiology of Status Epilepticus; Plasticity of GABAergic Synaptic Transmission
- Mark Kester
Nanotechnologies for targeted drug delivery
- Jonathan Kipnis
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
- Christopher M. Kramer
Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease
- Sarah C Kucenas
The role of glia in the development, maintenance and regeneration of the nervous system
- Charles Landen
Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
- Victor E. Laubach
Translational research into understanding cell and molecular mechanisms of lung ischemia-reperfusion (IR) injury following transplantation and defining new therapeutic targets to prevent such injury.
- Gordon W. Laurie
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
- Kevin S. Lee
Neuronal Vulnerability: A Study of Cellular Mechanism
- Norbert Leitinger
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
- William B. Levy
The neural bases of cognition; Computational theories of brain function
- Thomas P Loughran, Jr.
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
- Xiaowei Lu
Developmental regulation of planar cell polarity in the mammalian nervous system
- John R. Lukens
- Kevin R. Lynch
Chemical biology of sphingosine 1-phosphate
- Mani S. Mahadevan
Molecular Mechanisms of Myotonic Muscular Dystrophy
- James W. Mandell
Identification of Novel Biomarkers for Inflammatory Myopathies
- Marty W. Mayo
Transcriptional Regulation by NFKB
- Michael J McConnell
The Cause and Consequence of Somatic Mosaicism in Neurons
- Coleen A. McNamara
Atherosclerosis, Obesity, Diabetes
- Craig H. Meyer
Magnetic Resonance Imaging
- Kwon-Sik Park
Mechanisms of tumor progression and homeostasis
- Manoj Patel
Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
- Shayn M. Peirce-Cottler
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
- Edward Perez-Reyes
Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
- Benjamin W. Purow
Novel therapeutic approaches to brain cancers and to other neurologic diseases
- Kodi S. Ravichandran
Apoptotic cell clearance mechanisms in health and disease
- Michael L. Reed
Biomedical Applications of Microsystems and Nanotechnology
- David M. Rekosh
Human Immunodeficiency; Virus Gene Expression
- Christopher M. Rembold
Hypertension, Dyslipidemia, Insulin resistance, Sleep apnea, Statistical analysis, Smooth Muscle Contraction/Relaxation, Nitric Oxide
- Melanie Rutkowski
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
- Jogender Tushir Singh
Tailored fit targeting approaches: Cancer Immunotherapy, Bispecific Antibodies, Antibody-siRNA conjugates, Application in Cancer therapeutics
- Helmy M. Siragy
Endocrine hypertension, angiotensin receptors, renal paracrine hormones
- P. Todd Stukenberg
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
- Sundararaman Swaminathan
Inflammation, fibrosis, progression of kidney disease, diabetic nephropathy, cardiovascular disease, pathologic calcification, kidney transplantation
- Lukas K. Tamm
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
- Ronald P. Taylor
Clearance of Pathogens: The role of complement in Immunotherapy: New approaches to vaccine generation
- Mark B. Williams
Design, Development and Optimization of Medical Imaging Technologies
- Judith A. Woodfolk
Cellular and molecular mechanisms of allergic disease in humans.
- W. Michael Wormington
Regulation of miRNA Processing and Function During Oogenesis and Embryogenesis
- Victor Zaydfudim
Clinical outcomes research aimed at improving healthcare delivery and outcomes among patients with hepatopancreatobiliary diseases, Access to care, Clinical trials, Translational research, Intervention studies.
- J. Julius Zhu
Neural Circuits in Healthy and Diseased Brains