Generation of tissue microarrays (TMAs) from paraffin embedded clinical specimens allows several portions of many different tumors to be simultaneously examined histologically or probed for protein markers of disease using immunohistochemical methodologies. Using this approach, up to one hundred or more different tumors can be archived and tested on a single microscope slide. Courtesy of Dr. Christopher Moskaluk.

Translational Science at UVA focuses on transformative “bench-to-bedside” research accomplished through collaborations between basic and clinical scientists.  The synergistic environment generated by the close proximity of the University and the Medical Center supports teams working together on research problems that have the potential for immediate and/or short-term impact on human health.

Students interested in a career in translational science pursue individualized training programs that include relevant seminar series and journal clubs that focus on medically-applicable research, along with coursework offerings from across several degree granting programs that provide instruction in clinical problems and basic science approaches to address them.

Students benefit from the collaborative environment with ready access to physicians who can offer a clinical perspective to their basic science training.


  • Roger Abounader
    Basic and translational brain tumor research
  • Mazhar Adli
    Understanding and manipulating the genetics and epigenetics information to study stem cells, differentiation and cancer
  • Paula Q. Barrett
    Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
  • Douglas A. Bayliss
    Mechanisms of neuromodulation in central neurons
  • Stefan Bekiranov
    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
  • Stuart S. Berr
    Developing magnetic resonance (MR) techniques as a tool for basic biomedical research.
  • Edward H. Bertram
    Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
  • Sanchita Bhatnagar
    Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
  • Michelle Bland
    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
  • Amy H. Bouton
    Signaling Pathways and Breast Cancer
  • Timothy N. Bullock
    Pathways to enhance T cell function in tumors.
  • John H. Bushweller
    Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
  • Steven Caliari
    Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
  • Jessica J. Connelly
    Epigenetic mechanisms involved in complex human disease
  • Janet V. Cross
    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention; Anti-Inflammatory Benefits of Dietary Nutrient Compounds
  • Daniel A. Engel
    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
  • Victor H. Engelhard
    Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
  • Loren D. Erickson
    Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
  • Salem Faham
    Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
  • Robin A. Felder
    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
  • Jay W. Fox
    Basement Membrane Structure and Metalloproteinases
  • Cassandra L. Fraser
    Polymeric Metal Complexes. Metallobiomaterials for Medicine and Biotechnology. Bio-inspired and Sustainable Design. Responsive Nanoscale Assemblies.
  • Brent A. French
    Novel Therapies for Treating and Preventing Ischemic Heart Disease
  • Ravi K Ghanta
    Biotechnology, Translational Science
  • George T. Gillies
    Design of novel neurosurgical instrumentation systems, including magnetic stereotactic devices
  • Adam N. Goldfarb
    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
  • Michael J. Guertin
    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
  • Jennifer Guler
    Cell Biology and Parasitology.
  • Thurl E Harris
    Molecular mechanisms controlling insulin signaling and fat synthesis.
  • John C. Herr
    Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.
  • Erik L. Hewlett
    Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research
  • Jeffrey W. Holmes
    Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
  • Ku-Lung Hsu
    Lipid Metabolism in Inflammation and Immunity
  • Song Hu
    Photoacoustic imaging, light microscopy, neuroscience, microvascular biology
  • Brant Isakson
    Intercellular communication as it relates to blood pressure regulation
  • Jaideep Kapur
    Pathophysiology of Status Epilepticus; Plasticity of GABAergic Synaptic Transmission
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Jonathan Kipnis
    Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
  • Christopher M. Kramer
    Cardiac magnetic resonance imaging, myocardial disease, atherosclerotic plaque imaging, peripheral arterial disease
  • Sarah C Kucenas
    The role of glia in the development, maintenance and regeneration of the nervous system
  • Charles Landen
    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
  • Victor E. Laubach
    Translational research into understanding cell and molecular mechanisms of lung ischemia-reperfusion (IR) injury following transplantation and defining new therapeutic targets to prevent such injury.
  • Gordon W. Laurie
    Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
  • Kevin S. Lee
    Neuronal Vulnerability: A Study of Cellular Mechanism
  • Norbert Leitinger
    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
  • William B. Levy
    The neural bases of cognition; Computational theories of brain function
  • Thomas P Loughran, Jr.
    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
  • Xiaowei Lu
    Developmental regulation of planar cell polarity in the mammalian nervous system
  • John R. Lukens
    Neuroinflammatory disease
  • Kevin R. Lynch
    Chemical biology of sphingosine 1-phosphate
  • Mani S. Mahadevan
    Molecular Mechanisms of Myotonic Muscular Dystrophy
  • James W. Mandell
    Identification of Novel Biomarkers for Inflammatory Myopathies
  • Marty W. Mayo
    Transcriptional Regulation by NFKB
  • Michael J McConnell
    The Cause and Consequence of Somatic Mosaicism in Neurons
  • Coleen A. McNamara
    Atherosclerosis, Obesity, Diabetes
  • Craig H. Meyer
    Magnetic Resonance Imaging
  • Kwon-Sik Park
    Mechanisms of tumor progression and homeostasis
  • Manoj Patel
    Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
  • Shayn M. Peirce-Cottler
    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
  • Edward Perez-Reyes
    Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
  • Benjamin W. Purow
    Novel therapeutic approaches to brain cancers and to other neurologic diseases
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • Michael L. Reed
    Biomedical Applications of Microsystems and Nanotechnology
  • David M. Rekosh
    Human Immunodeficiency; Virus Gene Expression
  • Christopher M. Rembold
    Hypertension, Dyslipidemia, Insulin resistance, Sleep apnea, Statistical analysis, Smooth Muscle Contraction/Relaxation, Nitric Oxide
  • Melanie Rutkowski
    Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
  • Jogender Tushir Singh
    Tailored fit targeting approaches: Cancer Immunotherapy, Bispecific Antibodies, Antibody-siRNA conjugates, Application in Cancer therapeutics
  • Helmy M. Siragy
    Endocrine hypertension, angiotensin receptors, renal paracrine hormones
  • P. Todd Stukenberg
    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
  • Sundararaman Swaminathan
    Inflammation, fibrosis, progression of kidney disease, diabetic nephropathy, cardiovascular disease, pathologic calcification, kidney transplantation
  • Lukas K. Tamm
    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
  • Ronald P. Taylor
    Clearance of Pathogens: The role of complement in Immunotherapy: New approaches to vaccine generation
  • Mark B. Williams
    Design, Development and Optimization of Medical Imaging Technologies
  • Judith A. Woodfolk
    Cellular and molecular mechanisms of allergic disease in humans.
  • W. Michael Wormington
    Regulation of miRNA Processing and Function During Oogenesis and Embryogenesis
  • Victor Zaydfudim
    Clinical outcomes research aimed at improving healthcare delivery and outcomes among patients with hepatopancreatobiliary diseases, Access to care, Clinical trials, Translational research, Intervention studies.
  • J. Julius Zhu
    Neural Circuits in Healthy and Diseased Brains