- Biomedical Sciences Graduate Program | Neuroimmunology
Neuroimmunology is one of the fastest growing disciplines in all of science, which focuses on how crosstalk between the central nervous system (CNS) and the immune system contributes to health and disease. The University of Virginia is at the forefront of neuroimmunology research by cultivating a research environment that is highly collaborative and innovative.

The complete lack of effective biomedical interventions to treat debilitating neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and autism spectrum disorder has lead to a need to improve the characterization of the cellular and molecular mechanisms that promote neurological diseases. Recent findings strongly implicate dysfunctional immune responses in the pathogenesis of most, if not all, neurological disorders.  To characterize the immunological pathways that provoke neurological diseases a center for neuroimmunology research was established at UVA. The center for Brain Immunology and Glia (BIG) unites expertise in basic neuroscience, neuroinflammation, neurodegeneration, CNS infectious disease and immunology to tackle this important biomedical area.

Neuroimmunology research at UVA utilizes cutting-edge approaches to study the immunological underpinnings of multiple major neurological disorders including multiple sclerosis (MS), stroke, traumatic brain and spinal cord injury, CNS infectious disease, autism spectrum disorder, Alzheimer’s disease, brain cancer, depression, Rett syndrome, and schizophrenia. Much of this work is focused on identifying the specific immune pathways that spur CNS disease and investigating ways to harness the immune system to develop novel treatment strategies.

The overwhelming medical and societal burdens imposed by neurological disorders demands scientists with strong foundations in both neuroscience and immunology. Thus graduate students studying neuroimmunology at UVA are immersed in a dynamic and interdisciplinary training experience that encompasses neuroscience, immunology, behavioral neurobiology, imaging, bioinformatics and genomics, cell biology and clinical neurology. Our goal is to equip trainees with the necessary critical and creative thinking skills, technical expertise, and conceptual foundation in neuroscience and immunology to tackle important problems in all areas of neuroimmunology research. It is an exciting time to study neuroimmunology at UVA and we look forward to training the next generations of scientists who will lead the way in providing fundamental new insights into immune-mediated regulation of neurological function and disease.

Graduate students in the neuroimmunology research discipline are supported by the Medical Scientists Training Program (MSTP) grant, Neuroscience Training Grant, Immunology Training Grant, Pharmacology Training Grant and Wagner Fellowship.

Faculty

  • George S. Bloom
    Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
  • Anna Cliffe
    Herpes Simplex Virus Infection of Neurons
  • Alban Gaultier
    Exploring new therapeutics avenues to cure Multiple Sclerosis.
  • Tajie H. Harris
    Immune response to infectious disease in the CNS
  • Jonathan Kipnis
    Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
  • Sarah C Kucenas
    The role of glia in the development, maintenance and regeneration of the nervous system
  • Kyle Lampe
    Neural tissue engineering, biomaterials, drug delivery, redox regulation of stem cell fate, engineering cell-interactive microenvironments
  • Kevin S. Lee
    Neuronal Vulnerability: A Study of Cellular Mechanism
  • John R. Lukens
    Neuroinflammatory disease
  • James W. Mandell
    Identification of Novel Biomarkers for Inflammatory Myopathies
  • Michael J McConnell
    The Cause and Consequence of Somatic Mosaicism in Neurons
  • Jennifer Munson
    Engineering cell culture models to study the tumor microenvironment in the brain. Development of non-invasive in vivo imaging and drug delivery systems for cancers. Screening of compounds against cancer in engineered 3D cell culture models. Particular e
  • Benjamin W. Purow
    Novel therapeutic approaches to brain cancers and to other neurologic diseases
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • Hui Zong
    Mouse models of brain cancers