Nuclear hormone receptors are ligand activated transcription factors that regulate genetic networks controlling cell growth, development and metabolism. Binding of natural or synthetic agonists results in a conformational change (left side of figure) that alters the activity of receptors from transcriptional repressors to transcriptional activators. Treatment of mice with agonists for the liver X receptors results in a dramatic decrease in atherosclerosis (right side of figure) by promoting the removal of cholesterol from blood vessel walls. Courtesy of Dr. Ira G. Schulman.

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