Research in Metabolism at UVA focuses on the study of all chemical reactions in an organism and how dysregultation of these processes contributes to disease.These processes are tightly regulated under normal conditions to maintain homeostasis and ensure appropriate energy intake and fuel utilization.  Dysregulation of one or more fundamental metabolic processes causes alterations in glucose or lipid metabolism and transport, mitochondrial function, and cell signaling cascades that lead to chronic disease states such as obesity, diabetes, inflammation, and atherosclerosis.

The metabolism group at UVA actively investigates how and why these defects occur, with the ultimate goal of improving both preventative therapy and treatment.  The diverse expertise of the metabolism group provides training opportunities that utilize molecular and cellular biology in the context of whole animal physiology, drug discovery, and translational medicine.

Students in the metabolism group are supported by several institutional training grants including: Pharmacological Sciences Training Grant; Cell & Molecular Biology Training Grant; Neuroscience Training Program; and Biotechnology Training Program.


  • Michelle Bland
    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
  • Irina Bochkis
    Epigenetic and genetic mechanisms underlying metabolic disease
  • Mete Civelek
    Systems Genetics Approaches to Understand Cardiometabolic Traits
  • Christopher Deppmann
    Elucidating and Understanding the Mechanisms Underlying Nervous System Development
  • Sarah E Ewald
    Innate immunity, chronic disease, host-parasite interactions
  • Charles R. Farber
    Systems Genetics of Skeletal Development and Maintenance
  • Heather Ferris
    The Role of Diabetes in Cognitive Decline
  • Adam N. Goldfarb
    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
  • Jennifer Guler
    Cell Biology and Parasitology.
  • Adrian J. Halme
    Regeneration and Systemic Responses to Tissue Damage
  • Thurl E Harris
    Molecular mechanisms controlling insulin signaling and fat synthesis.
  • Ku-Lung Hsu
    Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
  • Song Hu
    Photoacoustic imaging, light microscopy, neuroscience, cardiovascular biology, cancer, regenerative medicine
  • Brant Isakson
    Translating our discoveries in the microcirculation to tangible benefits in patients.
  • Hao Jiang
    Regulation of stem cell function and tumorigenicity by epigenetics and biomolecular condensation
  • David F Kashatus
    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
  • Melissa M. Kendall
    Bacterial cell signaling, host-pathogen interactions, intestinal pathogens
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Bijoy Kundu
    Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
  • Gordon W. Laurie
    Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
  • Norbert Leitinger
    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
  • Eyleen Jorgelina O'Rourke
    Obesity and Aging
  • Jason Papin
    Systems biology, infectious disease, cancer, toxicology, metabolic engineering
  • David Parichy
    Developmental Genetics, Evolution and Regeneration of Adult Morphology in Vertebrates
  • Kwon-Sik Park
    Mechanisms of organ development and homeostasis and tumor development
  • Rebecca Pompano
    Bioanalytical tools for inflammatory disease
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • Ira G. Schulman
    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
  • Michael M. Scott
    Investigation of the neuronal circuits and epigenetic modifications involved in the control of food intake, impulsivity and novelty seeking behavior
  • Jeffrey S. Smith
    Transcriptional Silencing and Aging in Yeast
  • David Wotton
    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
  • Zhen Yan
    Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
  • James C Zimring
    Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease