Research in Infectious Diseases and Global Biothreats at UVA provides rich interdisciplinary experiences in the molecular biology, immunology, epidemiology, and pathogenesis of infectious diseases as well as vaccine development, therapeutics and diagnostic technologies for infectious agents.  Two different training programs support infectious diseases-related research.  Trainees have opportunities to conduct research with over 30 different mentors from eight different departments

The Infectious Diseases (ID) Training Program is currently in its 4th decade of consecutive NIH funding. This program brings together an internationally recognized clinical program in infectious diseases and international health and superb basic molecular and cellular biologists.  The core philosophy of the program is that interactions between basic scientists and clinicians in training  and research will spark innovative approaches to diagnose, treat and prevent infections

A basic philosophy of the program is that through interactions of basic scientists and clinicians in research and training, will come the breakthrough science that leads to new interventions to diagnose, treat and prevent infections.

The University of Virginia Global Biothreats Training (GBT) Program is based on the belief that a multidisciplinary approach is required to train investigators to understand, and ultimately to treat and prevent infections with global threat agents. This training program provides specialized and focused coursework and opportunities to converse and collaborate with experts in policy, social science, engineering, law, and national security through UVA’s Global Infectious Disease Institute. Special activities of this Program include graduate courses in Global Biothreats policy and emergency response, microbial pathogenesis, and interdisciplinary activities with the Global Infectious Diseases Institute.   State-of-the-art BSL3 and ABSL3 facilities are available to carry out biosafety level three work.

Both programs feature side-by-side education of predoctoral students, M.D.s, and Ph.D. postdoctoral fellows. Training is enriched by research-in-progress sessions, seminar series, and journal clubs that integrate both clinical and basic research aspects of infectious diseases.


  • Herve Agaisse
    Genetic approaches, cellular and molecular biology of intracellular pathogen infection
  • Timothy P. Bender
    Regulation of gene expression during lymphocyte development
  • Thomas J. Braciale
    T Lymphocyte Responses To Virus Infection
  • Michael G. Brown
    NK Cells and Viral Immunity, Genetics of host resistance to viral infection, Immunogenetics, Immune regulation
  • Timothy N. Bullock
    Pathways to enhance T cell function in tumors.
  • James E. Casanova
    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.
  • Anna Cliffe
    Herpes Simplex Virus Infection of Neurons
  • Alison K. Criss
    Cellular and molecular mechanisms of Neisserial pathogenesis
  • Isabelle Derre
    Host/pathogen Interaction - Chlamydia Infection
  • Daniel A. Engel
    Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
  • Sarah E Ewald
    Innate immunity, chronic disease, host-parasite interactions
  • Jennifer Guler
    Cell Biology and Parasitology.
  • Young S. Hahn
    Immune regulation for HCV infection and chronic liver inflammation
  • Marie-Louise Hammarskjöld
    Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
  • Tajie H. Harris
    Immune response to infectious disease in the CNS
  • Erik L. Hewlett
    Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research
  • Joel W. Hockensmith
    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
  • Peter M. Kasson
    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
  • Dean H. Kedes
    Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
  • Melissa M. Kendall
    Mechanisms used by Bacterial Pathogens to Integrate Host- and Bacterial-derived Signals to Sense their Environment, Coordinate Gene Expression, and Cause Disease
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Xiaowei Lu
    Developmental regulation of planar cell polarity in the mammalian nervous system
  • John R. Lukens
    Neuroinflammatory disease
  • Barbara J. Mann
    Pathogenicity of Francisella tularensis and vaccines
  • Shannon Moonah
    Host-pathogen interactions; molecular parasitology; mucosal inflammation; immunopathology
  • Jason Papin
    Systems biology, infectious disease, cancer, toxicology, metabolic engineering
  • William A Petri
    Molecular mechanisms of pathogenesis of parasitic infection
  • Owen Pornillos
    Structure and assembly of HIV Virus/host interactions Structural biology of the innate immune system
  • Girija Ramakrishnan
    Iron-uptake mechanisms and Virulence Factors of Francisella tularensis; Microbial Pathogenesis
  • David M. Rekosh
    Human Immunodeficiency; Virus Gene Expression
  • Michele Sale
    Genetics of stroke and otitis media
  • Nathan Swami
    Molecular and bioelectric devices; tissue regeneration.
  • Lukas K. Tamm
    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
  • Michael P. Timko
    Gene regulation during host-parasite interaction
  • Judith M. White
    Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
  • Steven L. Zeichner
    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
  • Jochen Zimmer
    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.