Organization of stromal cells in the lymph node. Lymph nodes were isolated, sectioned, and stained with fluorescent antibodies specific for lymphatic endothelial cells (red) and blood vascular endothelial cells (green). Other cells were visualized with a stain that detects their nuclei (blue). Such imaging is being used to study the movement of lymphocytes and dendritic cells into and out of the lymph node and how their localization influences the development of immune responses and immunological tolerance. Courtesy of Jarish Cohen, MSTP student in Dr. Victor Engelhard’s laboratory.

The Immunology Program at UVA includes research spanning basic development and regulation of the immune system to clinical trials.  Areas of interest include molecular aspects of B and T lymphocyte development, innate immunity, regulation of immune response quality, lymphocyte trafficking, modulation of immunity to viruses and bacteria, tumor immunology and immunotherapy, allergic diseases, autoimmunity, neuroimmunology and immunological perturbations in cardiovascular disease.

The Immunology Training Program consists of outstanding faculty, students and post-doctoral fellows performing cutting-edge research in a collaborative and collegial environment.  We provide students with an interdisciplinary training experience that emphasizes the breadth of immunology as well as cell and molecular biology.  The Training Program is funded in part by an NIH training grant in its 17th year, with 32 mentors providing cohesion and comprehensiveness.

The Program is integrated with and supported by the Department of Microbiology, Immunology, and Cancer Biology (MIC), the Carter Immunology Center, and the Center for Immunity, Inflammation, and Regenerative Medicine.  It also provides access to many state-of the-art research support facilities.

The program provides a creative and vibrant training environment that prepares students for careers in immunology research and the delivery of new and innovative therapies to patients.



  • Jayakrishna Ambati
    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
  • Timothy P. Bender
    Regulation of gene expression during lymphocyte development
  • Michelle Bland
    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
  • Amy H. Bouton
    Signaling Pathways and Breast Cancer
  • Thomas J. Braciale
    T Lymphocyte Responses To Virus Infection
  • Michael G. Brown
    NK Cells and Viral Immunity
  • Timothy N. Bullock
    Pathways to enhance T cell function in tumors.
  • James E. Casanova
    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.
  • Alison K. Criss
    Cellular and molecular mechanisms of Neisserial pathogenesis
  • Janet V. Cross
    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention; Anti-Inflammatory Benefits of Dietary Nutrient Compounds
  • Bimal N. Desai
    Electrical signals in inflammation and immunity
  • Victor H. Engelhard
    Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
  • Loren D. Erickson
    Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
  • Sarah E Ewald
    Innate immunity, chronic disease, host-parasite interactions
  • Young S. Hahn
    Immune regulation for HCV infection and chronic liver inflammation
  • Marie-Louise Hammarskjöld
    Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
  • Tajie H. Harris
    Immune response to infectious disease in the CNS
  • John C. Herr
    Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.
  • Ku-Lung Hsu
    Lipid Metabolism in Inflammation and Immunity
  • Dean H. Kedes
    Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Jonathan Kipnis
    Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
  • Victor E. Laubach
    Translational research into understanding cell and molecular mechanisms of lung ischemia-reperfusion (IR) injury following transplantation and defining new therapeutic targets to prevent such injury.
  • Norbert Leitinger
    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
  • Thomas P Loughran, Jr.
    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
  • Chance John Luckey
    Immune Memory
  • John R. Lukens
    Neuroinflammatory disease
  • Coleen A. McNamara
    Atherosclerosis, Obesity, Diabetes
  • Borna Mehrad
    Regulation of lung inflammation and antimicrobial immunity
  • William A. Petri
    Molecular Mechanisms of Pathogenesis of Parasitic Infection
  • Owen Pornillos
    Structure and assembly of HIV Virus/host interactions Structural biology of the innate immune system
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • David M. Rekosh
    Human Immunodeficiency; Virus Gene Expression
  • Melanie Rutkowski
    Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
  • Sundararaman Swaminathan
    Inflammation, fibrosis, progression of kidney disease, diabetic nephropathy, cardiovascular disease, pathologic calcification, kidney transplantation
  • Ronald P. Taylor
    Clearance of Pathogens: The role of complement in Immunotherapy: New approaches to vaccine generation
  • Kenneth S. Tung
    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
  • Judith A. Woodfolk
    Cellular and molecular mechanisms of allergic disease in humans.
  • Steven L. Zeichner
    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.