Real time analysis of chromosomes (green) and spindles (red). Courtesy of Dr. Daniel J. Burke.

Researchers in Genetics at UVA seek to understand how genetic information is encoded, inherited, decoded, and differentially regulated to produce the vast diversity observed in biology.

While the genome revolution has generated vast amounts of data on sequences and expression, genetics bridges the gap between structure (sequence) and biological function.  Fueled by powerful technologies for determining DNA sequences and surveying gene expression, geneticists seek to determine the function of every gene in the genome.  Functional data from genetic screens holds great promise for medicine, agriculture, pharmaceuticals and many other aspects of our lives.

The genetics program at the University of Virginia provides training opportunities with numerous faculty members across grounds.  It encompasses the full spectrum of genetic research, from genes to genomes to populations, in a diverse range of biological systems. We train graduates for careers in genetics at academic institutions, biotechnology and pharmaceutical companies, private research institutes, and government research laboratories.


  • Tarek A. Abbas
    The Ubiquitin System and Human Cancer
  • Paul N. Adler
    Planar signaling, polarity and morphogenesis.
  • Herve Agaisse
    Genetic approaches, cellular and molecular biology of intracellular pathogen infection
  • David T. Auble
    Molecular Mechanisms of Transcriptional Regulation
  • Timothy P. Bender
    Regulation of gene expression during lymphocyte development
  • Michelle Bland
    Molecular mechanisms linking inflammation and insulin signaling to control cell growth and metabolism
  • Michael G. Brown
    NK Cells and Viral Immunity
  • Wei-Min Chen
    Statistical genetics and genomics.
  • Mete Civelek
    Systems Genetics Approaches to Understand Cardiometabolic Traits
  • Jessica J. Connelly
    Epigenetic mechanisms involved in complex human disease
  • Claire R. Cronmiller
    Genetic Regulation of Morphogenesis and Reproduction in Drosophila
  • Isabelle Derre
    Host/pathogen Interaction - Chlamydia Infection
  • Noelle Dwyer
    Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
  • Charles R. Farber
    Systems Genetics of Skeletal Development and Maintenance
  • Robin A. Felder
    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
  • Robert M. Grainger
    Molecular embryology--gene regulation in cells committed to specific developmental lineages
  • Patrick A. Grant
    Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
  • Michael J. Guertin
    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
  • Adrian J. Halme
    Regeneration and Systemic Responses to Tissue Damage
  • Melissa M. Kendall
    Mechanisms used by Bacterial Pathogens to Integrate Host- and Bacterial-derived Signals to Sense their Environment, Coordinate Gene Expression, and Cause Disease
  • Sarah C Kucenas
    The role of glia in the development, maintenance and regeneration of the nervous system
  • Hui Li
    Gene regulation in cancer, development and reproductive systems; Epigenetic modification.
  • Xiaowei Lu
    Developmental regulation of planar cell polarity in the mammalian nervous system
  • Mani S. Mahadevan
    Molecular Mechanisms of Myotonic Muscular Dystrophy
  • Michael J McConnell
    The Cause and Consequence of Somatic Mosaicism in Neurons
  • Eyleen Jorgelina O'Rourke
    Obesity and Aging
  • Kwon-Sik Park
    Mechanisms of tumor progression and homeostasis
  • Lucy F. Pemberton
    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
  • Aakrosh Ratan
    Genomics, Molecular Evolution, Algorithm Design and Analysis
  • David M. Rekosh
    Human Immunodeficiency; Virus Gene Expression
  • Michele Sale
    Genetics of complex disease
  • Weibin Shi
    Cellular and genetic determinants of atherosclerosis and restenosis.
  • Sarah Siegrist
    Regulation of neural stem cell proliferation by extracellular factors, local and systemic. Intrinsic signaling programs regulating neural stem cell fate decisions: death versus survival. Functional and molecular similarities between Drosophila and mammal
  • Lawrence M. Silverman
    Modifier genes in cystic fibrosis; developing technologies in genomics and proteomics; epigenetics
  • M. Mitchell Smith
    Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle
  • Jeffrey S. Smith
    Transcriptional Silencing and Aging in Yeast
  • P. Todd Stukenberg
    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
  • Christine I. Thisse
    Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
  • Michael P. Timko
    Gene regulation during host-parasite interaction
  • Nassima Ait-Daoud Tiouririne
    Addiction Medicine, Neuroscience, and Pharmacology
  • Yuh-Hwa Wang
    Genome instability in human disease
  • Matthew J Wolf
    Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
  • David Wotton
    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
  • Jing Yu
    Mammalian kidney development
  • Hui Zong
    Mouse models of brain cancers