A single section of adult mouse brain was sequentially probed with polyclonal antibodies to markers of cell types. The resulting images were individually pseudocolored and overlaid to reveal the morphology of and interactions between neurons and support cells of the central nervous system. This sequential staining approach supports multiparametric antigen analyses in archival human tissue specimens. Courtesy of Dr. James Mandell

The Experimental Pathology Program incorporates researchers across UVA who study the molecular and cellular basis of human disease.  This work is facilitated by close interactions with clinical colleagues across the Health System who provide perspectives on challenges in patient care.

This rigorous training program takes advantage of a unique environment created by a faculty composed of basic scientists, research and diagnostic pathologists, and physician colleagues in other clinical specialties.

Traditional laboratory-based research is complemented by first hand exposure to clinical approaches used in the diagnosis and treatment of human disease.  Coursework is designed to complement laboratory research and highlights the interface between basic science and the challenges faced in clinical medicine.  In addition, opportunities exist to observe patient care directly through clinical rotations that allow students to experience the complete arc from diagnosis through therapeutic decisions to surgical, radiological or medical interventions.

The curriculum is enriched by a disease-focused participatory journal club and a seminar series that explores the molecular basis of human disease.  Students have ongoing access to the expertise of their clinical colleagues as well as laboratory and tissue specimens to facilitate their research projects.