A single section of adult mouse brain was sequentially probed with polyclonal antibodies to markers of cell types. The resulting images were individually pseudocolored and overlaid to reveal the morphology of and interactions between neurons and support cells of the central nervous system. This sequential staining approach supports multiparametric antigen analyses in archival human tissue specimens. Courtesy of Dr. James Mandell

The Experimental Pathology Program incorporates researchers across UVA who study the molecular and cellular basis of human disease.  This work is facilitated by close interactions with clinical colleagues across the Health System who provide perspectives on challenges in patient care.

This rigorous training program takes advantage of a unique environment created by a faculty composed of basic scientists, research and diagnostic pathologists, and physician colleagues in other clinical specialties.

Traditional laboratory-based research is complemented by first hand exposure to clinical approaches used in the diagnosis and treatment of human disease.  Coursework is designed to complement laboratory research and highlights the interface between basic science and the challenges faced in clinical medicine.  In addition, opportunities exist to observe patient care directly through clinical rotations that allow students to experience the complete arc from diagnosis through therapeutic decisions to surgical, radiological or medical interventions.

The curriculum is enriched by a disease-focused participatory journal club and a seminar series that explores the molecular basis of human disease.  Students have ongoing access to the expertise of their clinical colleagues as well as laboratory and tissue specimens to facilitate their research projects.



  • Jayakrishna Ambati
    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
  • Edward H. Bertram
    Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.
  • George S. Bloom
    Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
  • Timothy N. Bullock
    Pathways to enhance T cell function in tumors.
  • James E. Casanova
    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.
  • Janet V. Cross
    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention; Anti-Inflammatory Benefits of Dietary Nutrient Compounds
  • Robin A. Felder
    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
  • Brent A. French
    Novel Therapies for Treating and Preventing Ischemic Heart Disease
  • Adam N. Goldfarb
    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
  • R. Ariel Gomez
    Ontogeny of renin-angiotensis system, differentiation of the JG cell.
  • John C. Herr
    Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Jonathan Kipnis
    Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
  • Charles Landen
    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
  • Norbert Leitinger
    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
  • Hui Li
    Gene regulation in cancer, development and reproductive systems; Epigenetic modification.
  • John R. Lukens
    Neuroinflammatory disease
  • Mani S. Mahadevan
    Molecular Mechanisms of Myotonic Muscular Dystrophy
  • James W. Mandell
    Identification of Novel Biomarkers for Inflammatory Myopathies
  • Gary K. Owens
    Epigenetic Control of Perivascular and Stem Cell Plasticity/Trans-Differentiation during Injury-Repair and in Disease
  • Kenneth S. Tung
    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens