Research in Cell Biology and Developmental Biology at UVA features rich and diverse training in modern cell and developmental biology from a creative and internationally-recognized faculty.These programs highlight cutting-edge interests in morphogenesis and regenerative biology.  Ongoing research addresses fundamental issues at both the cellular level (membrane and cytoskeletal dynamics, signal transduction, mitosis, cell adhesion, motility, mechanotransduction, polarity) and higher-order processes such as embryonic patterning, morphogenetic movements, tissue morphogenesis and repair. These issues are examined in contexts that include cell culture models, differentiated tissues, patterning embryos, and tissues during development and wound repair.

Studies employing engineered mutant mice, Drosophila, Xenopus, and Zebrafish offer a range of venues for investigating fundamental mechanisms, their relationship to morphogenesis, and their dysfunction in human diseases.  Research in all of these areas employ the latest cell, molecular, biophysical, and microscopic technologies.

These programs foster a culture of collaboration that extends beyond any single department. Students commonly participate in institution-wide training programs in cancer biologycell biology and molecular biologybiotechnology, and cardiovascular research. The collegial and highly interactive learning environment incorporates seminars, journal clubs, colloquia, and research-in-progress presentations by students, postdocs, and faculty.

Faculty

  • Paul N. Adler
    Planar signaling, polarity and morphogenesis.
  • Huiwang Ai
    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
  • Robert A. Bloodgood
    Cell-Surface Glycoprotein Dynamics and Cell Locomotion
  • George S. Bloom
    Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
  • James E. Casanova
    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.
  • J. David Castle
    Intracellular cholesterol and the regulation of insulin secretion and membrane trafficking.
  • Jeffrey T. Corwin
    Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear.
  • Alison K. Criss
    Cellular and molecular mechanisms of Neisserial pathogenesis
  • Douglas W. DeSimone
    Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
  • Christopher Deppmann
    Elucidating and Understanding the Mechanisms Underlying Nervous System Development
  • Bimal N. Desai
    Ion channels and Ca2+-signaling in inflammation and immunity
  • Noelle Dwyer
    Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
  • Jennifer Guler
    Cell Biology and Parasitology.
  • Adrian J. Halme
    Regeneration and Systemic Responses to Tissue Damage
  • Barry T. Hinton
    Morphogenesis of the Developing Wolffian/Epididymal duct
  • David F Kashatus
    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
  • Raymond E. Keller
    Cellular and molecular mechanisms of morphogenesis
  • Keith G. Kozminski
    Regulation of Polarized Morphogenesis
  • Sarah C Kucenas
    The role of glia in the development, maintenance and regeneration of the nervous system
  • Gordon W. Laurie
    Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
  • Xiaowei Lu
    Developmental regulation of planar cell polarity in the mammalian nervous system
  • Eyleen Jorgelina O'Rourke
    Obesity and Aging
  • David Parichy
    Long-distance communication by specialized cellular projections, intersections of hormonal controls with local mechanisms of differentiation and morphogenesis, establishment and recruitment of post-embryonic stem cells during development and regeneration,
  • Lucy F. Pemberton
    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
  • Kenneth Kevin Pfister
    Regulation of Cytoplasmic Dynein for Membrane Bounded Organelle Trafficking in Axons
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • Stefanie Redemann
    Spindle assembly, the structure function relation and the basics of the huge variability of spindle size, architecture and mechanics between different tissues as well as different species
  • Dorothy A. Schafer
    Mechanisms of actin assembly during cell migration and membrane traffic
  • Jung-Bum Shin
    Auditory Neurobiology
  • Sarah Siegrist
    Regulation of neural stem cell proliferation by extracellular factors, local and systemic. Intrinsic signaling programs regulating neural stem cell fate decisions: death versus survival. Functional and molecular similarities between Drosophila and mammal
  • P. Todd Stukenberg
    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
  • Ann E. Sutherland
    Cell Matrix Interactions In Mouse Development
  • Lukas K. Tamm
    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
  • Bernard V. Thisse
    Molecular control of embryonic development
  • Christine I. Thisse
    Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
  • Scott B. Vande Pol
    We study viral oncoproteins oncoproteins as probes to elucidate cellular pathways regulating cellular signal transduction, and the development of cancer.
  • Judith M. White
    Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
  • Bettina Winckler
    Endosomal function and dysfunction in neurons
  • David Wotton
    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
  • Jing Yu
    Mammalian kidney development
  • Scott O. Zeitlin
    Mechanisms of Huntington's Disease Pathogenesis
  • Hui Zong
    Mouse models of brain cancers