Scanning electron micrograph of capillaries from the spinotrapezious muscle of the mouse. Courtesy of Dr. Brant Isakson.
Cardiovascular Research at UVA focuses on mechanisms that contribute to major cardiovascular diseases such as atherosclerosis, aneurysms, hypertension, peripheral vascular disease, heart failure, myocardial infarction, and stroke.

Over 150 former trainees now hold leadership positions in academia, industry, and other biomedical science-related disciplines.   Students perform research in one of the many laboratories housed in our world-renowned Robert M. Berne Cardiovascular Research Center (CVRC).    Training is augmented through our NIH-funded Cardiovascular Research Training Program, which prepares students for highly successful biomedical research careers in a broad range of areas, including studies of basic cardiovascular development and function.  Our research also focuses on the development of novel drugs, devices, diagnostic methods, imaging modalities, and other therapeutic approaches to better diagnose, prevent, or treat cardiovascular disease.

Faculty

  • Brian H. Annex
    Angiogenesis; peripheral arterial disease (PAD); gene therapy
  • Paula Q. Barrett
    Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
  • Thomas J. Braciale
    T Lymphocyte Responses To Virus Infection
  • Mete Civelek
    Systems Genetics Approaches to Understand Cardiometabolic Traits
  • Jessica J. Connelly
    Epigenetic mechanisms involved in complex human disease
  • Andrew Dudley
    Tumor microenvironment and mechanisms of tumor neovascularization
  • Victor H. Engelhard
    Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
  • Frederick H. Epstein
    Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion
  • Salem Faham
    Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
  • Robin A. Felder
    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
  • Brent A. French
    Novel Therapies for Treating and Preventing Ischemic Heart Disease
  • R. Ariel Gomez
    Ontogeny of renin-angiotensis system, differentiation of the JG cell.
  • William H. Guilford
    Molecular Mechanics of Muscle Contraction and Cell Movement
  • Patrice G. Guyenet
    Neural control of blood pressure and respiration
  • Thurl E Harris
    Molecular mechanisms controlling insulin signaling and fat synthesis.
  • Brian P. Helmke
    Intracellular Mechanics and Cell Function
  • Jeffrey W. Holmes
    Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
  • John A. Hossack
    Diagnostic Ultrasound Transducers; Beam Forming and Imaging. Breast Ultrasound; Obstructive Sleep Apnea; 3D Ultrasound and Microbubbles
  • Song Hu
    Photoacoustic imaging, light microscopy, neuroscience, microvascular biology
  • Brant Isakson
    Intercellular communication as it relates to blood pressure regulation
  • Kevin A. Janes
    Systems-biology approaches to cancer biology and virology.
  • Kimberly Kelly
    Advancement in the design of imaging agents; molecular imaging and radiological sciences.
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Howard C. Kutchai
    Quaternary Structure of Calcium-ATPases of sarcoplasmic reticulum and Na, K-ATPase and Its Regulatory Significance
  • Victor E. Laubach
    Translational research into understanding cell and molecular mechanisms of lung ischemia-reperfusion (IR) injury following transplantation and defining new therapeutic targets to prevent such injury.
  • Michael B. Lawrence
    Vascular and Molecular Engineering
  • Kevin S. Lee
    Neuronal Vulnerability: A Study of Cellular Mechanism
  • Norbert Leitinger
    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
  • Kevin R. Lynch
    Chemical biology of sphingosine 1-phosphate
  • Coleen A. McNamara
    Atherosclerosis, Obesity, Diabetes
  • Craig H. Meyer
    Magnetic Resonance Imaging
  • Eyleen Jorgelina O'Rourke
    Obesity and Aging
  • Gary K. Owens
    Epigenetic Control of Perivascular and Stem Cell Plasticity/Trans-Differentiation during Injury-Repair and in Disease
  • Jason Papin
    Systems biology, infectious disease, cancer, toxicology, metabolic engineering
  • Shayn M. Peirce-Cottler
    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
  • Richard J. Price
    Endothelial Phenotypes in Angiogenesis, Integrated Signaling for Microvascular Network Patterning, and Contrast Ultrasound Based Therapeutics
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • Stephen S. Rich
    Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis
  • Michele Sale
    Genetics of complex disease
  • Ira G. Schulman
    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
  • Helmy M. Siragy
    Endocrine hypertension, angiotensin receptors, renal paracrine hormones
  • Avril V. Somlyo
    Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.
  • Kenneth S. Tung
    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
  • Matthew J Wolf
    Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.
  • Zhen Yan
    Molecular and Signaling Mechanisms of Skeletal Muscle Plasticity
  • Paul A. Yates
    Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.
  • Mark Yeager
    Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus