Adhesion signaling is disrupted in cancer cells. This image shows how we visualize cell adhesions using immunofluorescence microscopy. Each color marks a different protein that is present in adhesions that form between the cell and the extracellular matrix. Courtesy of Drs. Karen Martin and J. Thomas Parsons
Cancer Biology at UVA focuses on cutting-edge basic, translational, and clinical research in a highly collaborative environment.  Our research is significantly enhanced by being part of an NCI-designated Cancer Center whose mission is in part to discover the fundamental causes of cancer and develop new knowledge into tools for cancer treatment, diagnosis, and prevention.

For over 35 years the University of Virginia Cancer Training Program has been preparing students for productive careers in academia, industry and education.  Students pursue research under world-renowned faculty in areas such as cancer cell signaling, genetics and epigenetics, chemical and structural biology, immunology and immunotherapy, inflammation and cancer, and interactions between tumor cells and non-transformed stromal components of the tumor microenvironment.

Integration of student training with the UVA NCI-designated Cancer Center provides an exceptional opportunity to prepare students for leadership roles in all aspects of cancer research and to ultimately shape the future of this rapidly expanding area of biomedical research.  Students work closely with research teams in women’s oncology, lung cancer, gastrointestinal cancers, hematopoietic malignancies and stem cell research.  This research is augmented by state-of-the-art research and clinical facilities that deliver new and innovative therapies to patients.

 

Faculty

  • Tarek A. Abbas
    The Ubiquitin System and Human Cancer
  • Roger Abounader
    Basic and translational brain tumor research
  • Mazhar Adli
    Understanding and manipulating the genetics and epigenetics information to study stem cells, differentiation and cancer
  • Stefan Bekiranov
    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
  • Timothy P. Bender
    Regulation of gene expression during lymphocyte development
  • Stuart S. Berr
    Developing magnetic resonance (MR) techniques as a tool for basic biomedical research.
  • Sanchita Bhatnagar
    Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
  • Amy H. Bouton
    Signaling Pathways and Breast Cancer
  • David L. Brautigan
    Protein Phosphorylation in Cell Signaling
  • Jay C. Brown
    Structure and Assembly of the Herpes Simplex Virus Capsid.
  • Timothy N. Bullock
    Pathways to enhance T cell function in tumors.
  • John H. Bushweller
    Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
  • Steven Caliari
    Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
  • James E. Casanova
    Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
    Cell Biology of bacterial pathogenesis.
    The innate immune response to bacterial infection.
  • Janet V. Cross
    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention; Anti-Inflammatory Benefits of Dietary Nutrient Compounds
  • Andrew Dudley
    Tumor microenvironment and mechanisms of tumor neovascularization
  • Anindya Dutta
    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer
  • Noelle Dwyer
    Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
  • Victor H. Engelhard
    Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
  • Loren D. Erickson
    Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
  • Salem Faham
    Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
  • Jay W. Fox
    Basement Membrane Structure and Metalloproteinases
  • Cassandra L. Fraser
    Polymeric Metal Complexes. Metallobiomaterials for Medicine and Biotechnology. Bio-inspired and Sustainable Design. Responsive Nanoscale Assemblies.
  • Zheng "John" Fu
    Cell signaling of protein kinases in development and disease
  • Daniel Gioeli
    Signal transduction in cancer cells
  • Adam N. Goldfarb
    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
  • Patrick A. Grant
    Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
  • Michael J. Guertin
    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
  • Adrian J. Halme
    Regeneration and Systemic Responses to Tissue Damage
  • Marie-Louise Hammarskjöld
    Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
  • Joel W. Hockensmith
    Novel antiprotozoan and anticancer compounds from antibiotic-resistant bacteria
  • Ku-Lung Hsu
    Lipid Metabolism in Inflammation and Immunity
  • Song Hu
    Photoacoustic imaging, light microscopy, neuroscience, microvascular biology
  • Kevin A. Janes
    Systems-biology approaches to cancer biology and virology.
  • David F Kashatus
    The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
  • Dean H. Kedes
    Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Charles Landen
    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
  • John S. Lazo
    The mechanism of action of small molecules and the fundamental biological role of protein tyrosine phosphatases
  • Matthew Lazzara
    Cellular Engineering
  • Kevin S. Lee
    Neuronal Vulnerability: A Study of Cellular Mechanism
  • Hui Li
    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
  • Thomas P Loughran, Jr.
    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
  • Xiaowei Lu
    Developmental regulation of planar cell polarity in the mammalian nervous system
  • James W. Mandell
    Identification of Novel Biomarkers for Inflammatory Myopathies
  • Marty W. Mayo
    Transcriptional Regulation by NFKB
  • Christopher A. Moskaluk
    Molecular pathogenesis and genomic analysis of human cancers
  • Gary K. Owens
    Epigenetic Control of Perivascular and Stem Cell Plasticity/Trans-Differentiation during Injury-Repair and in Disease
  • Kwon-Sik Park
    Mechanisms of tumor progression and homeostasis
  • Bryce M. Paschal
    Nuclear Transport, Signaling, and Cancer
  • Lucy F. Pemberton
    Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
  • Richard J. Price
    Endothelial Phenotypes in Angiogenesis, Integrated Signaling for Microvascular Network Patterning, and Contrast Ultrasound Based Therapeutics
  • Benjamin W. Purow
    Novel therapeutic approaches to brain cancers and to other neurologic diseases
  • Aakrosh Ratan
    Genomics, Molecular Evolution, Algorithm Design and Analysis
  • Kodi S. Ravichandran
    Apoptotic cell clearance mechanisms in health and disease
  • David M. Rekosh
    Human Immunodeficiency; Virus Gene Expression
  • Melanie Rutkowski
    Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
  • Dorothy A. Schafer
    Mechanisms of actin assembly during cell migration and membrane traffic
  • Ira G. Schulman
    Regulation of transcription by nuclear hormone receptors, transcriptional control of metabolism, atherosclerosis, Small molecule approaches to drug discovery
  • Nathan Sheffield
    Computational regulatory genomics
  • Jogender Tushir Singh
    Tailored fit targeting approaches: Cancer Immunotherapy, Bispecific Antibodies, Antibody-siRNA conjugates, Application in Cancer therapeutics
  • Jill K. Slack-Davis
    Molecular Mechanisms Regulating Ovarian Cancer Metastasis
  • M. Mitchell Smith
    Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle
  • P. Todd Stukenberg
    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
  • Nathan Swami
    Molecular and bioelectric devices; tissue regeneration.
  • Christine I. Thisse
    Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
  • Yuh-Hwa Wang
    Genome instability in human disease
  • Michael J. Weber
    Targeting Cell Signaling for Cancer Therapy.
  • W. Michael Wormington
    Regulation of miRNA Processing and Function During Oogenesis and Embryogenesis
  • David Wotton
    Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
  • Steven L. Zeichner
    Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.
  • Jochen Zimmer
    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
  • Hui Zong
    Mouse models of brain cancers
  • Eli Zunder
    Stem Cell Behavior