Biophysicists at UVA utilize quantitative approaches to understand the physical and chemical basis of complex biological processes.
Biological processes are studied at every level and across many fields, from the theoretical to the experimental.
The Biophysics Graduate Program at the University of Virginia is one of the oldest in the country. We employ a wide range of experimental and computational approaches in a highly interactive and multidisciplinary environment. One of our strengths is in the study of membranes, which are of fundamental importance for biological systems. Membranes compartmentalize the cell, thereby controlling the internal cellular environment. They are sites for energy transduction and signaling. Finally, many regulatory processes take place at membrane surfaces.
Students in biophysics at UVA gain a strong foundation in biophysical approaches and analysis through innovative research and didactic coursework.
- David T. Auble
Molecular Mechanisms of Transcriptional Regulation
- Paula Q. Barrett
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
- Douglas A. Bayliss
Mechanisms of neuromodulation in central neurons
- Stefan Bekiranov
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
- Jay C. Brown
Structure and Assembly of the Herpes Simplex Virus Capsid.
- John H. Bushweller
Structural and Functional Basis for Oncogenesis; Targeted Drug Development; Structural Studies of Membrane Proteins
- David S. Cafiso
Molecular Mechanisms for Membrane Transport and Cell Signaling
- Steven Caliari
Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
- J. David Castle
Intracellular cholesterol and the regulation of insulin secretion and membrane trafficking.
- Linda Columbus
Biophysical Chemistry: Membrane protein structure, function, and dynamics
- Carl E. Creutz
Calcium-dependent, membrane-binding proteins and mechanisms of exocytosis
- Zygmunt S. Derewenda
Structure-function relationships in proteins
- Kateri H. DuBay
The design of self-assembling nanomaterials
- Edward H. Egelman
Structure and Function of Macromolecular Complexes Using Electron Microscopy
- Salem Faham
Structural biology of membrane proteins; Structure/function and structure/stability relationships and the development of new tools for protein crystallization.
- Robin A. Felder
Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
- Andreas Gahlmann
Bacterial cell biology at the molecular level
- George T. Gillies
Design of novel neurosurgical instrumentation systems, including magnetic stereotactic devices
- William H. Guilford
Molecular Mechanics of Muscle Contraction and Cell Movement
- Tajie H. Harris
Immune response to infectious disease in the CNS
- Brian P. Helmke
Intracellular Mechanics and Cell Function
- Jeffrey W. Holmes
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
- John A. Hossack
Diagnostic Ultrasound Transducers; Beam Forming and Imaging. Breast Ultrasound; Obstructive Sleep Apnea; 3D Ultrasound and Microbubbles
- Ku-Lung Hsu
Lipid Metabolism in Inflammation and Immunity
- Brant Isakson
Intercellular communication as it relates to blood pressure regulation
- Peter M. Kasson
Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
- Raymond E. Keller
Cellular and molecular mechanisms of morphogenesis
- Kimberly Kelly
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
- Mark Kester
Nanotechnologies for targeted drug delivery
- Bijoy Kundu
Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy
- James P. Landers
Bioanalytical Chemistry on Microchips
- Michael B. Lawrence
Vascular and Molecular Engineering
- William B. Levy
The neural bases of cognition; Computational theories of brain function
- Deforest Mellon
Sensory System Organization and Development
- Wladek Minor
Structure-Function Relationships in Proteins; Structural Genomics; Bioinformatics
- Cameron Mura
Structure, function & evolution of RNA-processing assemblies; structural and computational biology; molecular biophysics
- Robert K. Nakamoto
Structure-Function of Active Transporters
- Jason Papin
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
- Manoj Patel
Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
- William R. Pearson
Protein Evolution; Computational Biology
- Shayn M. Peirce-Cottler
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
- Ammasi Periasamy
Imaging of Proteins in Living (or fixed) Cells and Tissues Using Light Microscopy Systems
- Rebecca Pompano
Our lab develops methods based on microfluidic culture systems, bioanalytical techniques, and spatially resolved simulations to quantify the spatiotemporal dynamics of the inflammatory cascade and develop targeted therapies.
- Owen Pornillos
Structure and assembly of HIV Virus/host interactions Structural biology of the innate immune system
- Richard J. Price
Endothelial Phenotypes in Angiogenesis, Integrated Signaling for Microvascular Network Patterning, and Contrast Ultrasound Based Therapeutics
- Christopher Stroupe
Biochemical, biophysical, structural, and cell biological studies of intracellular membrane tethering and fusion
- P. Todd Stukenberg
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
- Nathan Swami
Molecular and bioelectric devices; tissue regeneration.
- Lukas K. Tamm
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
- B. Jill Venton
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
- Judith M. White
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
- Michael C. Wiener
Structural biology (esp. crystallography) of integral membrane proteins; TonB-dependent active transport across the bacterial outer membrane; cancer-related membrane proteins; crystallization methods development
- Mark B. Williams
Design, Development and Optimization of Medical Imaging Technologies
- Mark Yeager
Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus
- J. Julius Zhu
Neural Circuits in Healthy and Diseased Brains
- Jochen Zimmer
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.