Research in Biophysics at UVA utilizes quantitative approaches to understand the physical and chemical basis of complex biological processes.Biological processes are studied at every level and across many fields, from the theoretical to the experimental.

The Biophysics Graduate Program at the University of Virginia is one of the oldest in the country. We employ a wide range of experimental and computational approaches in a highly interactive and multidisciplinary environment.  One of our strengths is in the study of membranes, which are of fundamental importance for biological systems. Membranes compartmentalize the cell, thereby controlling the internal cellular environment.  They are sites for energy transduction and signaling.  Finally, many regulatory processes take place at membrane surfaces.

Students in biophysics at UVA gain a strong foundation in biophysical approaches and analysis through innovative research and didactic coursework.

Faculty

  • Huiwang Ai
    Spatiotemporal Regulation of Biological Signaling; Protein Engineering for Imaging, Diagnostics, and Therapeutics
  • David T. Auble
    Molecular Mechanisms of Transcriptional Regulation
  • Stefan Bekiranov
    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
  • John H. Bushweller
    Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins
  • David S. Cafiso
    Molecular Mechanisms for Membrane Transport and Cell Signaling
  • Wei-Min Chen
    Statistical genetics and genomics.
  • Linda Columbus
    Biophysical Chemistry: Membrane protein structure, function, and dynamics
  • Zygmunt S. Derewenda
    Structure-function relationships in proteins
  • Kateri H. DuBay
    The design of self-assembling nanomaterials
  • Edward H. Egelman
    Structure and Function of Macromolecular Complexes Using Electron Microscopy
  • Roseanne M. Ford
    Bacterial attachment and biofilms, microbial transport in porous media
  • Andreas Gahlmann
    Super-resolution fluorescence imaging of bacterial cells
  • Barbie Ganser-Pornillos
    The Structural Biology of HIV assembly
  • Ku-Lung Hsu
    Chemical Biology, Lipid Biochemistry, Medicinal Chemistry, and Mass Spectrometry
  • Donald F. Hunt
    Analytical Biochemistry
  • Peter M. Kasson
    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
  • Dean H. Kedes
    Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
  • Yong I. Kim
    Ion Channel Dysfunction in Neurological Disorders
  • James P. Landers
    Bioanalytical Chemistry on Microchips
  • Michael B. Lawrence
    Vascular and Molecular Engineering
  • Norbert Leitinger
    Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
  • Kevin R. Lynch
    Chemical biology of sphingosine 1-phosphate
  • Wladek Minor
    Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
  • Robert K. Nakamoto
    Structure-Function of Active Transporters
  • Manoj Patel
    Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
  • Shayn M. Peirce-Cottler
    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
  • Edward Perez-Reyes
    Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
  • Owen Pornillos
    Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system
  • Stefanie Redemann
    Spindle assembly, the structure function relation and the basics of the huge variability of spindle size, architecture and mechanics between different tissues as well as different species
  • Jeffrey J. Saucerman
    Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
  • Avril V. Somlyo
    Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.
  • P. Todd Stukenberg
    Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
  • Lukas K. Tamm
    Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
  • B. Jill Venton
    Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
  • Judith M. White
    Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
  • Michael C. Wiener
    Structural biology (esp. crystallography) of integral membrane proteins; TonB-dependent active transport across the bacterial outer membrane; cancer-related membrane proteins; crystallization methods development
  • Mark B. Williams
    Design, Development and Optimization of Medical Imaging Technologies
  • Mark Yeager
    Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus
  • Jochen Zimmer
    Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.