Genome-wide analysis of KLF4 gene regulation in 8 diverse cell types (ENCODE project). Courtesy of Dr. Ira Hall.

Researchers in Bioinformatics and Genomics at UVA use quantitative methods to describe the behavior of genes, genomes, and biological systems.

At the intersection of experimental and computational biology, genomics research involves interpretation and integration of large-scale, genome-wide datasets.

These approaches are being applied to diverse topics in biology and medicine including cancer genomics, human and model organism genetics, epigenetics, and evolution. Active areas of research at the University of Virginia include whole-genome sequencing, cancer genome evolution, disease gene mapping, personalized medicine, gene expression profiling, epigenome mapping, high-throughput functional genetics, genome annotation, protein evolution, and pathway reconstruction.

Genomics and bioinformatics research often requires the development of new techniques, including both experimental protocols and data analysis algorithms, to enable a deeper understanding of complex biological systems. In this respect, the field is entering a new and exciting era; rapidly improving “next-generation” DNA sequencing technologies now allow for the routine sequencing of entire genomes and transcriptomes, or of virtually any targeted set of DNA or RNA molecules.

The exponential explosion of genomic data fueled by these technologies presents an unprecedented opportunity to elucidate the molecular underpinnings of natural variation and human disease, but the sheer abundance and complexity of these data also pose significant and unsolved bioinformatic challenges. The scope of these opportunities and challenges promises to revolutionize biology and medicine.


  • Mazhar Adli
    Understanding and manipulating the genetics and epigenetics information to study stem cells, differentiation and cancer
  • David T. Auble
    Molecular Mechanisms of Transcriptional Regulation
  • Stefan Bekiranov
    Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
  • Timothy P. Bender
    Regulation of gene expression during lymphocyte development
  • Sanchita Bhatnagar
    Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
  • Michael G. Brown
    NK Cells and Viral Immunity
  • Jay C. Brown
    Structure and Assembly of the Herpes Simplex Virus Capsid.
  • Wei-Min Chen
    Statistical genetics and genomics.
  • Anindya Dutta
    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer
  • Charles R. Farber
    Systems Genetics of Skeletal Development and Maintenance
  • Robin A. Felder
    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
  • R. Ariel Gomez
    Ontogeny of renin-angiotensis system, differentiation of the JG cell.
  • Robert M. Grainger
    Molecular embryology--gene regulation in cells committed to specific developmental lineages
  • Michael J. Guertin
    Transcription, Chromatin, Cancer, Molecular Biology, Genomics, and Computational Biology
  • Jennifer Guler
    Cell Biology and Parasitology.
  • John C. Herr
    Spermatogenesis and oogenesis; fertilization; cancer-testis and cancer-oocyte neoantigens.
  • Jeffrey W. Holmes
    Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
  • Kevin A. Janes
    Systems-biology approaches to cancer biology and virology.
  • Peter M. Kasson
    Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
  • Melissa M. Kendall
    Mechanisms used by Bacterial Pathogens to Integrate Host- and Bacterial-derived Signals to Sense their Environment, Coordinate Gene Expression, and Cause Disease
  • Robert H. Kretsinger
    Structure and Mechanism of Enzymes; Evolution of Ca-Modulated Proteins
  • Sarah C Kucenas
    The role of glia in the development, maintenance and regeneration of the nervous system
  • Thomas P Loughran, Jr.
    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
  • Michael J McConnell
    The Cause and Consequence of Somatic Mosaicism in Neurons