The Molecular and Cellular Basis of Disease (MCBD) graduate program confers the PhD in Experimental Pathology.  The program is designed for students with a research interest in the mechanisms of human disease processes, with a particular emphasis on the skills necessary to perform translational research. In addition to basic laboratory skills, the program offers the opportunity for collaborative work with top-ranked and internationally recognized pathologists and other clinicians as part of PhD training. These experiences provide our trainees with an understanding of modern medical problems and a unique perspective on approaches to move research from bench to bedside.

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Program Faculty

  • Jayakrishna Ambati
    Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
  • Thomas H. Barker
    My lab is primarily focused on both understanding and manipulating cell-ECM mechanotransduction pathways in homeostasis and disease. Our primary interest is in understanding how cells’ changing microenvironment direct their phenotype and initiate patholo
  • George S. Bloom
    Pathogenic mechanisms in Alzheimer’s Disease and other neurodegenerative disorders
  • Thomas J. Braciale
    T Lymphocyte Responses To Virus Infection
  • Michael G. Brown
    NK Cells and Viral Immunity, Genetics of host resistance to viral infection, Immunogenetics, Immune regulation
  • Timothy N. Bullock
    Pathways to enhance T cell function in tumors.
  • Steven Caliari
    Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment
  • George Christ
    Functional Genomics
  • Janet V. Cross
    Contribution of the Inflammatory Microenvironment to Tumor Initiation, Progression and Metastasis; Molecular Mechanisms of Cancer Chemoprevention; Anti-Inflammatory Benefits of Dietary Nutrient Compounds
  • Anindya Dutta
    Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer
  • Robin A. Felder
    Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.
  • Heather Ferris
    The Role of Diabetes in Cognitive Decline
  • Alban Gaultier
    Exploring new therapeutics avenues to cure Multiple Sclerosis.
  • Bradley Gelfand
    Blinding disease age-related macular degeneration, utilizing the tools of immunology, molecular biology, and engineering.
  • Daniel Gioeli
    Signal transduction in cancer cells
  • Adam N. Goldfarb
    Hematopathology and Understanding the Molecular Basis of Hematopoiesis and Leukemogenesis
  • Kevin A. Janes
    Systems-biology approaches to cancer biology and virology.
  • Mark Kester
    Nanotechnologies for targeted drug delivery
  • Charles Landen
    Mechanisms of Chemotherapy Resistance in Ovarian and Other Gynecologic Malignancies
  • Hui Li
    Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
  • Thomas P Loughran, Jr.
    Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
  • Chance John Luckey
    Immune Memory
  • Mani S. Mahadevan
    Molecular Mechanisms of Myotonic Muscular Dystrophy
  • James W. Mandell
    Identification of Novel Biomarkers for Inflammatory Myopathies
  • Coleen A. McNamara
    Atherosclerosis, Obesity, Diabetes
  • Christopher A. Moskaluk
    Molecular pathogenesis and genomic analysis of human cancers
  • Gary K. Owens
    Epigenetic Control of Perivascular and Stem Cell Plasticity/Trans-Differentiation during Injury-Repair and in Disease
  • Jason Papin
    Systems biology, infectious disease, cancer, toxicology, metabolic engineering
  • Bryce M. Paschal
    Nuclear Transport, Signaling, and Cancer
  • Shayn M. Peirce-Cottler
    Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
  • William A Petri
    Molecular mechanisms of pathogenesis of parasitic infection
  • Benjamin W. Purow
    Novel therapeutic approaches to brain cancers and to other neurologic diseases
  • Kenneth S. Tung
    Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
  • Scott B. Vande Pol
    We study papillomavirus oncoproteins as probes to elucidate cellular pathways regulating cellular signal transduction, and the development of cancer. Projects: Oncoprotein E6 and the regulation of integrin signaling and Cdc48.
  • Paul A. Yates
    Development and regulation of retinal ganglion cells (RGCs) and blood vessels as they relate to retinal diseases.