Zhiyi Zuo


  • MD, Zhongshan Medical College
  • MS, Sun Yat Sen University of Medical Sciences
  • PhD, University of Cambridge

Primary Appointment

  • Professor, Anesthesiology


Research Interest(s)

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Research Description

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Selected Publications

  • Cao J, Wang Z, Mi W, Zuo Z. Isoflurane unveils a critical role of glutamate transporter type 3 in regulating hippocampal GluR1 trafficking and context-related learning and memory in mice. Neuroscience. 2014;272 58-64. PMID: 24797327 | PMCID: PMC4077290
  • Chiao S, Zuo Z. A double-edged sword: volatile anesthetic effects on the neonatal brain. Brain sciences. 2014;4(2): 273-94. PMID: 24961761 | PMCID: PMC4101477
  • Yu H, Deng J, Zuo Z. High-fat diet reduces neuroprotection of isoflurane post-treatment: Role of carboxyl-terminal modulator protein-Akt signaling. Obesity (Silver Spring, Md.). 2014. PMID: 25142024
  • Zhang J, Tan H, Jiang W, Zuo Z. Amantadine Alleviates Postoperative Cognitive Dysfunction Possibly by Increasing Glial Cell Line-derived Neurotrophic Factor in Rats. Anesthesiology. 2014;121(4): 773-785. PMID: 25251457 | PMCID: PMC4176814
  • Zhao P, Ji G, Xue H, Yu W, Zhao X, Din M, Yang Y, Zuo Z. Isoflurane postconditioning improved long-term neurological outcome possibly via inhibiting the mitochondrial permeability transition pore in neonatal rats after brain hypoxia-ischemia. Neuroscience. 2014. PMID: 25241064
  • Blum F, Zuo Z. Volatile anesthetics-induced neuroinflammatory and anti-inflammatory responses. Medical gas research. 2013;3(1): 16. PMID: 23915963 | PMCID: PMC3733838
  • Hou Q, Zuo Z, Michel P, Zhang Y, Eskandari A, Man F, Gao Q, Johnston K, Wintermark M. Influence of chronic hyperglycemia on cerebral microvascular remodeling: an in vivo study using perfusion computed tomography in acute ischemic stroke patients. Stroke; a journal of cerebral circulation. 2013;44(12): 3557-60. PMID: 24029632
  • Zhang J, Jiang W, Zuo Z. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB. Neuroscience. 2013;261 1-10. PMID: 24365462 | PMCID: PMC3950371
  • A Novel Mechanism for Sevoflurane Preconditioning-induced Neuroprotection. Anesthesiology. 2012. PMID: 22929733 | PMCID: NIHMS404800
  • Cao L, Feng C, Li L, Zuo Z. Contribution of microRNA-203 to the isoflurane preconditioning-induced neuroprotection. Brain research bulletin. 2012;88(5): 525-8. PMID: 22609621 | PMCID: PMC3381978
  • Cao L, Li L, Lin D, Zuo Z. Isoflurane induces learning impairment that is mediated by interleukin 1β in rodents. PloS one. 2012;7(12): e51431. PMID: 23251531 | PMCID: PMC3520904
  • Lee S, Park S, Zuo Z. Effects of isoflurane on learning and memory functions of wild-type and glutamate transporter type 3 knockout mice. The Journal of pharmacy and pharmacology. 2012;64(2): 302-7. PMID: 22221107
  • Feng C, Cao L, Zuo Z. RNA interference-produced autoregulation of inducible nitric oxide synthase expression. FEBS letters. 2011;585(15): 2488-92. PMID: 21741974 | PMCID: PMC3148287
  • Feng C, Li J, Zuo Z. Expression of the transcription factor regulatory factor X1 in the mouse brain. Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society. 2011;49(2): 344-51. PMID: 21744337 | PMCID: PMC3220163
  • Gwak M, Cao L, Li L, Zuo Z. Isoflurane preconditioning reduces oxygen-glucose deprivation-induced neuronal injury via B-cell lymphoma 2 protein. Environmental toxicology and pharmacology. 2011;31(1): 262-5. PMID: 21359097 | PMCID: PMC3045195
  • Huang Y, Li L, Washington J, Xu X, Sando J, Lin D, Zuo Z. Inhibition of isoflurane-induced increase of cell-surface redistribution and activity of glutamate transporter type 3 by serine 465 sequence-specific peptides. European journal of pharmacology. 2011;655(1): 16-22. PMID: 21266171 | PMCID: PMC3055949
  • Li J, Sheng W, Feng C, Zuo Z. Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia. Neurobiology of disease. 2011;45(1): 564-72. PMID: 21983158 | PMCID: PMC3225696
  • Li L, Zuo Z. Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability. Neuroscience. 2011;199 44-50. PMID: 22040798 | PMCID: PMC3237819
  • Lin D, Cao L, Wang Z, Li J, Washington J, Zuo Z. Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats. Behavioural brain research. 2011;228(2): 319-27. PMID: 22192381 | PMCID: PMC3268839
  • Lin D, Li G, Zuo Z. Volatile anesthetic post-treatment induces protection via inhibition of glycogen synthase kinase 3β in human neuron-like cells. Neuroscience. 2011;179 73-9. PMID: 21277352 | PMCID: PMC3059391
  • Lin D, Zuo Z. Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats. Neuropharmacology. 2011;61(8): 1354-9. PMID: 21864548 | PMCID: PMC3189329
  • Varhabhatla N, Zuo Z. The effects of chronic pulmonary disease on hospital length of stay and cost of hospitalization after neurosurgery. Clinical article. Journal of neurosurgery. 2011;115(2): 375-9. PMID: 21495820
  • Antonakakis J, Scalzo D, Jorgenson A, Figg K, Ting P, Zuo Z, Sites B. Ultrasound does not improve the success rate of a deep peroneal nerve block at the ankle. Regional anesthesia and pain medicine. 2010;35(2): 217-21. PMID: 20301828
  • Feng J, Zuo Z. Isoflurane preconditioning increases endothelial cell tolerance to in-vitro simulated ischaemia. The Journal of pharmacy and pharmacology. 2010;63(1): 106-10. PMID: 21155822 | PMCID: PMC3058629
  • Gwak M, Li L, Zuo Z. Morphine preconditioning reduces lipopolysaccharide and interferon-gamma-induced mouse microglial cell injury via delta 1 opioid receptor activation. Neuroscience. 2010;167(2): 256-60. PMID: 20156527 | PMCID: PMC2849923
  • Lee S, Li L, Zuo Z. Glutamate transporter type 3 knockout mice have a decreased isoflurane requirement to induce loss of righting reflex. Neuroscience. 2010;171(3): 788-93. PMID: 20875840 | PMCID: PMC3401886
  • Li L, Zuo Z. Glutamate transporter type 3 knockout reduces brain tolerance to focal brain ischemia in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010;31(5): 1283-92. PMID: 21139629 | PMCID: PMC3099634
  • Lin D, Feng C, Cao M, Zuo Z. Volatile anesthetics may not induce significant toxicity to human neuron-like cells. Anesthesia and analgesia. 2010;112(5): 1194-8. PMID: 20966438
  • McMurtrey R, Zuo Z. Isoflurane preconditioning and postconditioning in rat hippocampal neurons. Brain research. 2010;1358 184-90. PMID: 20709037 | PMCID: PMC2949531
  • Raphael J, Gozal Y, Navot N, Zuo Z. Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. Journal of cardiovascular pharmacology. 2010;55(4): 348-57. PMID: 20125034
  • Wu X, Lin D, Li G, Zuo Z. Statin post-treatment provides protection against simulated ischemia in bovine pulmonary arterial endothelial cells. European journal of pharmacology. 2010;636(1): 114-20. PMID: 20361961 | PMCID: PMC2866815
  • Kim J, Li L, Zuo Z. Delayed treatment with isoflurane attenuates lipopolysaccharide and interferon gamma-induced activation and injury of mouse microglial cells. Anesthesiology. 2009;111(3): 566-73. PMID: 19672189 | PMCID: PMC2740753
  • Li L, Zuo Z. Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats. Neuroscience. 2009;164(2): 497-506. PMID: 19679170 | PMCID: PMC2762026
  • Lee J, Li L, Jung H, Zuo Z. Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. Anesthesiology. 2008;108(6): 1055-62. PMID: 18497606 | PMCID: PMC2666347
  • Xu X, Kim J, Zuo Z. Isoflurane preconditioning reduces mouse microglial activation and injury induced by lipopolysaccharide and interferon-gamma. Neuroscience. 2008;154(3): 1002-8. PMID: 18495358 | PMCID: PMC2492758