Yuh-Hwa Wang

Education

  • PhD, North Carolina State University

Primary Appointment

  • Associate Professor, Biochemistry and Molecular Genetics

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Thys R, Lehman C, Pierce L, Wang Y. DNA secondary structure at chromosomal fragile sites in human disease. Current genomics. 2015;16(1): 60-70. PMID: 25937814 | PMCID: PMC4412965
  • Thys R, Lehman C, Pierce L, Wang Y. Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells. Mutation research. 2015;779 86-95. PMID: 26163765
  • Thys R, Wang Y. DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene. The Journal of biological chemistry. 2015;290(48): 28953-62. PMID: 26463209 | PMCID: PMC4661408
  • Reddy K, Schmidt M, Geist J, Thakkar N, Panigrahi G, Wang Y, Pearson C. Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability. Nucleic acids research. 2014;42(16): 10473-87. PMID: 25147206
  • Axford M, Wang Y, Nakamori M, Zannis-Hadjopoulos M, Thornton C, Pearson C. Detection of Slipped-DNAs at the Trinucleotide Repeats of the Myotonic Dystrophy Type I Disease Locus in Patient Tissues. PLoS genetics. 2013;9(12): e1003866. PMID: 24367268 | PMCID: PMC3868534
  • Dillon L, Pierce L, Lehman C, Nikiforov Y, Wang Y. DNA topoisomerases participate in fragility of the oncogene RET. PloS one. 2013;8(9): e75741. PMID: 24040417 | PMCID: PMC3770543
  • Dillon L, Pierce L, Ng M, Wang Y. Role of DNA secondary structures in fragile site breakage along human chromosome 10. Human molecular genetics. 2013;22(7): 1443-56. PMID: 23297364 | PMCID: PMC3596854
  • Dillon L, Lehman C, Wang Y. The role of fragile sites in sporadic papillary thyroid carcinoma. Journal of thyroid research. 2012;2012 927683. PMID: 22762011 | PMCID: PMC3384961
  • Dillon L, Burrow A, Wang Y. DNA instability at chromosomal fragile sites in cancer. Current genomics. 2011;11(5): 326-37. PMID: 21286310 | PMCID: PMC2944998
  • Burrow A, Marullo A, Holder L, Wang Y. Secondary structure formation and DNA instability at fragile site FRA16B. Nucleic acids research. 2010;38(9): 2865-77. PMID: 20071743 | PMCID: PMC2875025
  • Gandhi M, Dillon L, Pramanik S, Nikiforov Y, Wang Y. DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells. Oncogene. 2010;29(15): 2272-80. PMID: 20101222 | PMCID: PMC2855398
  • Wan C, Kulkarni A, Wang Y. ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. Mutation research. 2010;686(1): 39-46. PMID: 20060399 | PMCID: PMC2834799
  • Burrow A, Williams L, Pierce L, Wang Y. Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites. BMC genomics. 2009;10 59. PMID: 19183484 | PMCID: PMC2642838
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