Young S. Hahn


  • BA, Yon Sei University, Seoul, Korea
  • PhD, California Institute of Technology
  • Postdoc, Washington University School of Medicine

Primary Appointment

  • Professor, Microbiology, Immunology, and Cancer Biology


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Selected Publications

  • Dolina J, Braciale T, Hahn Y. Liver-primed CD8(+) T cells suppress antiviral adaptive immunity through galectin-9-independent T-Cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Hepatology (Baltimore, Md.). 2014;59(4): 1351-65. PMID: 24677194
  • Lee H, Narayanan S, Park S, Seong S, Hahn Y. Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex. The Journal of biological chemistry. 2014;289(8): 5310-9. PMID: 24385435
  • Dolina J, Sung S, Novobrantseva T, Nguyen T, Hahn Y. Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity. Molecular therapy. Nucleic acids. 2013;2 e72. PMID: 23423360 | PMCID: PMC3586800
  • Goh C, Narayanan S, Hahn Y. Myeloid-derived suppressor cells: the dark knight or the joker in viral infections? Immunological reviews. 2013;255(1): 210-21. PMID: 23947357 | PMCID: PMC3748397
  • Tosello-Trampont A, Landes S, Nguyen V, Novobrantseva T, Hahn Y. Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through TNFα production. The Journal of biological chemistry. 2012. PMID: 23066023 | PMCID: PMC3504730
  • Krueger P, Lassen M, Qiao H, Hahn Y. Regulation of NK cell repertoire and function in the liver. Critical reviews in immunology. 2011;31(1): 43-52. PMID: 21395510 | PMCID: PMC3163300
  • Tacke R, Tosello-Trampont A, Nguyen V, Mullins D, Hahn Y. Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. The Journal of biological chemistry. 2011;286(12): 10847-55. PMID: 21282107 | PMCID: PMC3060535
  • Hall C, Kassel R, Tacke R, Hahn Y. HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta. PloS one. 2010;5(8): e12154. PMID: 20730048 | PMCID: PMC2921368
  • Lassen M, Lukens J, Dolina J, Brown M, Hahn Y. Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state. Journal of immunology (Baltimore, Md. : 1950). 2010;184(5): 2693-701. PMID: 20124099 | PMCID: PMC2885840
  • Cummings K, Rosen H, Hahn Y. Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clinical immunology (Orlando, Fla.). 2009;132(3): 401-11. PMID: 19473882 | PMCID: PMC2720442
  • Kassel R, Cruise M, Iezzoni J, Taylor N, Pruett T, Hahn Y. Chronically inflamed livers up-regulate expression of inhibitory B7 family members. Hepatology (Baltimore, Md.). 2009;50(5): 1625-37. PMID: 19739236 | PMCID: PMC2897253
  • Lukens J, Dolina J, Kim T, Tacke R, Hahn Y. Liver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system. PloS one. 2009;4(10): e7619. PMID: 19876399 | PMCID: PMC2764869
  • Lukens J, Cruise M, Lassen M, Hahn Y. Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. Journal of immunology (Baltimore, Md. : 1950). 2008;180(7): 4875-84. PMID: 18354211 | PMCID: PMC2904552
  • Cummings K, Waggoner S, Tacke R, Hahn Y. Role of complement in immune regulation and its exploitation by virus. Viral immunology. 2007;20(4): 505-24. PMID: 18158725
  • Cruise M, Lukens J, Nguyen A, Lassen M, Waggoner S, Hahn Y. Fas ligand is responsible for CXCR3 chemokine induction in CD4+ T cell-dependent liver damage. Journal of immunology (Baltimore, Md. : 1950). 2006;176(10): 6235-44. PMID: 16670334
  • Yao Z, Waggoner S, Cruise M, Hall C, Xie X, Oldach D, Hahn Y. SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function. Journal of virology. 2005;79(24): 15417-29. PMID: 16306613 | PMCID: PMC1315996