Xiaowei Lu


  • BS, Beijing University
  • PhD, Massachusetts Institute of Technology
  • Postdoc, University of California, San Francisco

Primary Appointment

  • Associate Professor, Cell Biology


Research Interest(s)

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Research Description

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Selected Publications

  • Andreeva A, Lee J, Lohia M, Wu X, Macara I, Lu X. PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity. Developmental cell. 2014;29(1): 20-33. PMID: 24703874 | PMCID: PMC4086913
  • Williams M, Yen W, Lu X, Sutherland A. Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate. Developmental cell. 2014;29(1): 34-46. PMID: 24703875 | PMCID: PMC4120093
  • Sipe C, Liu L, Lee J, Grimsley-Myers C, Lu X. Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development (Cambridge, England). 2013;140(8): 1785-95. PMID: 23533177 | PMCID: PMC3621493
  • Lee J, Andreeva A, Sipe C, Liu L, Cheng A, Lu X. PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium. Current biology : CB. 2012;22(11): 956-66. PMID: 22560610 | PMCID: PMC3407606
  • Sipe C, Lu X. Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development (Cambridge, England). 2011;138(16): 3441-9. PMID: 21752934 | PMCID: PMC3143564
  • Paudyal A, Damrau C, Patterson V, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris D, Dean C, Henderson D, Murdoch J. The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC developmental biology. 2010;10 87. PMID: 20704721 | PMCID: PMC2930600
  • Grimsley-Myers C, Sipe C, Géléoc G, Lu X. The small GTPase Rac1 regulates auditory hair cell morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009;29(50): 15859-69. PMID: 20016102 | PMCID: PMC2847287
  • Yen W, Williams M, Periasamy A, Conaway M, Burdsal C, Keller R, Lu X, Sutherland A. PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation. Development (Cambridge, England). 2009;136(12): 2039-48. PMID: 19439496 | PMCID: PMC2685725
  • Andersen E, Lu X, Horvitz H. C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates. Development (Cambridge, England). 2006;133(14): 2695-704. PMID: 16774993
  • Harrison M, Ceol C, Lu X, Horvitz H. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proceedings of the National Academy of Sciences of the United States of America. 2006;103(45): 16782-7. PMID: 17075059 | PMCID: PMC1636532
  • Williams M, Lu X, McKenna W, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, Hinck L. UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Nature neuroscience. 2006;9(8): 996-8. PMID: 16829956
  • Friedel R, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkatesh T, Yaron A, Hynes M, Chen B, Okada A, McConnell S, Rayburn H, Tessier-Lavigne M. Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(37): 13188-93. PMID: 16129827 | PMCID: PMC1193537
  • Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas J, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004;432(7014): 179-86. PMID: 15510105