Wynn Legon


  • BA, York University
  • MSc, York University
  • PhD, University of Waterloo
  • Fellowship, Sunnybrook Hospital
  • Fellowship, Virginia Tech Carilion Research Institute


Research Interest(s)

Non-invasive neuromodulation

Research Description

We study the use of ultrasound for non-invasive neuromodulation. The work in the lab employs several techniques including transcranial magnetic stimulation (TMS), electroencephalography (EEG), electromyography (EMG), magnetic resonance imaging (MRI), stereotaxic neuronavigation, computational acoustic modelling and empirical acoustic testing.

Selected Publications

  • Legon W, Ai L, Bansal P, Mueller J. Neuromodulation with single-element transcranial focused ultrasound in human thalamus. Human brain mapping. 2018. PMID: 29380485
  • Mueller J, Ai L, Bansal P, Legon W. Numerical evaluation of the skull for human neuromodulation with transcranial focused ultrasound. Journal of neural engineering. 2017;14(6): 066012. PMID: 28777075
  • Mueller J, Ai L, Bansal P, Legon W. Computational exploration of wave propagation and heating from transcranial focused ultrasound for neuromodulation. Journal of neural engineering. 2016;13(5): 056002. PMID: 27464603
  • Legon W, Punzell S, Dowlati E, Adams S, Stiles A, Moran R. Altered Prefrontal Excitation/Inhibition Balance and Prefrontal Output: Markers of Aging in Human Memory Networks. Cerebral cortex (New York, N.Y. : 1991). 2015;26(11): 4315-4326. PMID: 26400915
  • Neren D, Johnson M, Legon W, Bachour S, Ling G, Divani A. Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury. Neurocritical care. 2015;24(2): 308-19. PMID: 26399249
  • Opitz A, Legon W, Mueller J, Barbour A, Paulus W, Tyler W. Is sham cTBS real cTBS? The effect on EEG dynamics. Frontiers in human neuroscience. 2015;8 1043. PMID: 25620925 | PMCID: PMC4287020
  • Legon W, Sato T, Opitz A, Mueller J, Barbour A, Williams A, Tyler W. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nature neuroscience. 2014;17(2): 322-9. PMID: 24413698
  • Mueller J, Legon W, Opitz A, Sato T, Tyler W. Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics. Brain stimulation. 2014;7(6): 900-8. PMID: 25265863
  • Dionne J, Legon W, Staines W. Crossmodal influences on early somatosensory processing: interaction of vision, touch, and task-relevance. Experimental brain research. 2013;226(4): 503-12. PMID: 23455852
  • Legon W, Dionne J, Staines W. Continuous theta burst stimulation of the supplementary motor area: effect upon perception and somatosensory and motor evoked potentials. Brain stimulation. 2013;6(6): 877-83. PMID: 23706289
  • Opitz A, Legon W, Rowlands A, Bickel W, Paulus W, Tyler W. Physiological observations validate finite element models for estimating subject-specific electric field distributions induced by transcranial magnetic stimulation of the human motor cortex. NeuroImage. 2013;81 253-64. PMID: 23644000
  • Legon W, Rowlands A, Opitz A, Sato T, Tyler W. Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and FMRI. PloS one. 2012;7(12): e51177. PMID: 23226567 | PMCID: PMC3514181
  • Neva J, Legon W, Staines W. Primary motor cortex excitability is modulated with bimanual training. Neuroscience letters. 2012;514(2): 147-51. PMID: 22405809
  • Legon W, Dionne J, Meehan S, Staines W. Non-dominant hand movement facilitates the frontal N30 somatosensory evoked potential. BMC neuroscience. 2010;11 112. PMID: 20822535 | PMCID: PMC2940928
  • Dionne J, Meehan S, Legon W, Staines W. Crossmodal influences in somatosensory cortex: Interaction of vision and touch. Human brain mapping. 2009;31(1): 14-25. PMID: 19572308
  • Meehan S, Legon W, Staines W. Spatiotemporal properties modulate intermodal influences on early somatosensory processing during sensory-guided movement. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2009;120(7): 1371-80. PMID: 19501547
  • Legon W, Meehan S, Staines W. The relationship between frontal somatosensory-evoked potentials and motor planning. Neuroreport. 2008;19(1): 87-91. PMID: 18281899
  • Meehan S, Legon W, Staines W. Paired-pulse transcranial magnetic stimulation of primary somatosensory cortex differentially modulates perception and sensorimotor transformations. Neuroscience. 2008;157(2): 424-31. PMID: 18838111
  • Legon W, Staines W. Predictability of the target stimulus for sensory-guided movement modulates early somatosensory cortical potentials. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2006;117(6): 1345-53. PMID: 16644272