Wei-Min Chen

Primary Appointment

  • Assistant Professor, Public Health Sciences

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Research Interest(s)

My research focuses on the design and statistical analysis of human gene mapping data. Recently, my research has focused on the development of methods for analyzing genome-wide SNP data in datasets that include thousands of individuals.

Research Description



My research focuses on the design and statistical analysis of human gene mapping data. Recently, my research has focused on the development of methods for analyzing genome-wide SNP data in datasets that include thousands of individuals.

Genome Wide Association Analysis
I developed a general procedure to infer missing genotypes in family-based genomewide association studies (Chen and Abecasis 2007). This work allows efficient use of family collections in genome wide association (GWA) studies, especially when the GWA follows an initial linkage scan. With this approach, only a few selected individuals in each family need to be genotyped during the GWA, and genotypes of the remaining individuals can be
mostly inferred based on the information from flanking markers and relatives. In this work, I also proposed efficient tests for GWA analysis of quantitative traits that allow for uncertainty in the estimation of missing genotypes. These methodologies have been successfully applied to the genomewide association analysis of the gene expression data as well as a large GWA study of ~100 aging related quantitative traits (mainly cardiovascular and personality traits) in >6,000 individuals from Sardinia.

Robust Linkage and Association Tests
I developed a general methodology framework for quantitative trait linkage analysis making use of the Generalized Estimating Equations (GEE) (Chen et al. 2004). Using this framework, I proposed novel robust linkage tests and investigated commonly used linkage methods (Chen et al. 2005).

Power Analysis of Linkage and Association
I developed an efficient method to perform analytical power calculation for the variance component linkage analysis in pedigrees of any size (Chen and Abecasis 2006). I also developed a general approach to calculate the power of the Transmission/Disequilibrium Test (TDT), a widely-used test and design for association studies (Chen and Deng 2001).

Selected Publications

  • He W, Chai H, Chen W, Zhang J, Xu Y, Zhu J, Wang W. Facial emotion triggered cerebral potentials in treatment-resistant depression and borderline personality disorder patients of both genders. Progress in neuro-psychopharmacology & biological psychiatry. 2011;37(1): 121-7. PMID: 22200559
  • He X, Chen W, Huang Q. Surface display of monkey metallothionein α tandem repeats and EGFP fusion protein on Pseudomonas putida X4 for biosorption and detection of cadmium. Applied microbiology and biotechnology. 2011;95(6): 1605-13. PMID: 22205441
  • Lu Y, Chen C, Chen H, Zhang J, Chen W. Isolation and Identification of Endophytic Fungi from Actinidia macrosperma and Investigation of Their Bioactivities. Evidence-based complementary and alternative medicine : eCAM. 2011;2012 382742. PMID: 22203869 | PMCID: PMC3235672
  • Prabakaran P, Chen W, Singarayan M, Stewart C, Streaker E, Feng Y, Dimitrov D. Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations. Immunogenetics. 2011;64(5): 337-50. PMID: 22200891
  • Pullela S, Andres C, Chen W, Xu C, Wang L, Kotov N. Permselectivity Replication of Artificial Glomerular Basement Membranes in Nanoporous Collagen Multilayers. The journal of physical chemistry letters. 2011;2(16): 2067-2072. PMID: 22200004 | PMCID: PMC3243758
  • Sun S, Ke Z, Wang F, Li S, Chen W, Han A, Wang Z, Shi H, Wang L, Chen X. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Human pathology. 2011;43(7): 1051-60. PMID: 22204714
  • Yuan H, Wang Z, Li L, Zhang H, Modi H, Horne D, Bhatia R, Chen W. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood. 2011;119(8): 1904-14. PMID: 22207735 | PMCID: PMC3293644