Victor E. Laubach


  • BA,BS, Pennsylvania State University, University Park, PA
  • PhD, George Washington University School of Medicine

Primary Appointment

  • Professor, Surgery


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Techniques used in the lab:

Routine techniques we use in the laboratory include cell culture, purification of primary cells, quantitative RT-PCR, flow cytometry, FACS, ELISA, multiplex (bead-array) cytokine assay, Western blot, ELISPOT assay, gene array, immunohistochemistry, biochemical assays, confocal microscopy and oxidative stress evaluation. Some murine methods we use include thoracic surgery, bone marrow transplantation, immune cell ablation, adoptive transfer of immune cells, pulmonary function measurements using an isolated mouse lung system, bronchoalveolar lavage, and measurement of pulmonary microvascular permeability.

Selected Publications

  • Nicolls M, Laubach V. Traumatic Brain Injury: Lungs in a RAGE. Science translational medicine. 2014;6(252): 252fs34. PMID: 25186173
  • Sharma A, LaPar D, Stone M, Zhao Y, Kron I, Laubach V. Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013;13(9): 2255-67. PMID: 23865790 | PMCID: PMC3776006
  • Mulloy D, Stone M, Crosby I, Lapar D, Sharma A, Webb D, Lau C, Laubach V, Kron I. Ex vivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: delayed perfusion results in superior lung function. The Journal of thoracic and cardiovascular surgery. 2012;144(5): 1208-15. PMID: 22944084 | PMCID: PMC3477251
  • Emaminia A, Lapar D, Zhao Y, Steidle J, Harris D, Laubach V, Linden J, Kron I, Lau C. Adenosine A₂A agonist improves lung function during ex vivo lung perfusion. The Annals of thoracic surgery. 2011;92(5): 1840-6. PMID: 22051279 | PMCID: PMC3259746
  • Lapar D, Hajzus V, Zhao Y, Lau C, French B, Kron I, Sharma A, Laubach V. Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. American journal of respiratory cell and molecular biology. 2011;46(3): 299-305. PMID: 21980055 | PMCID: PMC3326427
  • Sharma A, LaPar D, Zhao Y, Li L, Lau C, Kron I, Iwakura Y, Okusa M, Laubach V. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. American journal of respiratory and critical care medicine. 2011;183(11): 1539-49. PMID: 21317314 | PMCID: PMC3137143
  • Gazoni L, Walters D, Unger E, Linden J, Kron I, Laubach V. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. The Journal of thoracic and cardiovascular surgery. 2010;140(2): 440-6. PMID: 20398911 | PMCID: PMC2906677
  • Laubach V, French B, Okusa M. Targeting of adenosine receptors in ischemia-reperfusion injury. Expert opinion on therapeutic targets. 2010;15(1): 103-18. PMID: 21110787 | PMCID: PMC3075429
  • Laubach V, Kron I. Pulmonary inflammation after lung transplantation. Surgery. 2009;146(1): 1-4. PMID: 19541003 | PMCID: PMC2700777
  • Sharma A, Linden J, Kron I, Laubach V. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respiratory research. 2009;10 58. PMID: 19558673 | PMCID: PMC2711962
  • Yang Z, Sharma A, Linden J, Kron I, Laubach V. CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. The Journal of thoracic and cardiovascular surgery. 2009;137(3): 695-702; discussion 702. PMID: 19258091 | PMCID: PMC2670927