Victor E. Laubach

Education

  • BA,BS, Pennsylvania State University, University Park, PA
  • PhD, George Washington University School of Medicine

Primary Appointment

  • Professor, Surgery

Contact

Research Interest(s)

Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.

Research Description

My laboratory conducts translational studies into mechanisms and prevention of lung ischemia-reperfusion (IR) injury following transplantation. IR injury is a rapid and robust inflammatory response that leads to increased morbidity and mortality after lung transplant. Our research utilizes both in vivo and in vitro models to explore inflammatory signaling pathways in innate immune cells, alveolar epithelial cells and vascular endothelial cells as well as cross-talk among these cells. One NIH-funded project is aimed at defining the role of pannexin 1 (Panx1)-derived extracellular ATP in mediating lung IR injury through activation of endothelial cells, neutrophils, and alveolar macrophages via purinergic signaling pathways. A second NIH-funded project is the development of novel molecular imaging probes (to target specific cells such as neutrophils or M1 and M2 macrophages) for non-invasive PET and SPECT imaging in order to provide early diagnosis of lung IR injury and to permit early therapeutic intervention. A third NIH-funded project utilizes the novel technique of ex vivo lung perfusion (EVLP) in which injured donor lungs undergo ex vivo perfusion in order to assess function prior to transplantation. We are testing various protective, anti-inflammatory treatments during EVLP to recondition injured donor lungs and prevent graft failure after transplantation. Other projects in the lab include: 1) understanding the resolution of lung IR injury and how we can augment this protective pathway in transplanted lungs, 2) studying the role of NADPH oxidase (NOX2)-derived superoxide production in the activation of various pulmonary cell types during IR injury, and 3) defining the role of calcium uptake by various cells via TRPV4 channels during lung IR injury.

Selected Publications

  • Dimastromatteo J, Charles E, Laubach V. Molecular imaging of pulmonary diseases. Respiratory research. 2018;19(1): 17. PMID: 29368614 | PMCID: PMC5784614
  • Sharma A, Charles E, Zhao Y, Narahari A, Baderdinni P, Good M, Lorenz U, Kron I, Bayliss D, Ravichandran K, Isakson B, Laubach V. Pannexin 1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. American journal of physiology. Lung cellular and molecular physiology. 2018. PMID: 29745255
  • Stone M, Zhao Y, Robert Smith J, Weiss M, Kron I, Laubach V, Sharma A. Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death. Respiratory research. 2017;18(1): 212. PMID: 29268735 | PMCID: PMC5740880
  • Charles E, Huerter M, Wagner C, Sharma A, Zhao Y, Stoler M, Mehaffey J, Isbell J, Lau C, Tribble C, Laubach V, Kron I. Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion. The Annals of thoracic surgery. 2016;102(6): 1845-1853. PMID: 27614736 | PMCID: PMC5112144
  • Huerter M, Sharma A, Zhao Y, Charles E, Kron I, Laubach V. Attenuation of Pulmonary Ischemia-Reperfusion Injury by Adenosine A2B Receptor Antagonism. The Annals of thoracic surgery. 2016;102(2): 385-93. PMID: 27109193 | PMCID: PMC4958568
  • Laubach V, Sharma A. Mechanisms of lung ischemia-reperfusion injury. Current opinion in organ transplantation. 2016. PMID: 26945320 | PMCID: PMC4861054
  • Sharma A, LaPar D, Stone M, Zhao Y, Mehta C, Kron I, Laubach V. NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2A Receptor to Inhibit Lung Ischemia-Reperfusion Injury. American journal of respiratory and critical care medicine. 2016;193(9): 988-99. PMID: 26757359 | PMCID: PMC4872653
  • Stone M, Sharma A, Mas V, Gehrau R, Mulloy D, Zhao Y, Lau C, Kron I, Huerter M, Laubach V. Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. Transplantation. 2015;99(12): 2494-503. PMID: 26262504 | PMCID: PMC4668207
  • Stone M, Sharma A, Zhao Y, Charles E, Huerter M, Johnston W, Kron I, Lynch K, Laubach V. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. American journal of physiology. Lung cellular and molecular physiology. 2015;308(12): L1245-52. PMID: 25910934 | PMCID: PMC4587601
  • Sharma A, LaPar D, Stone M, Zhao Y, Kron I, Laubach V. Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013;13(9): 2255-67. PMID: 23865790 | PMCID: PMC3776006
  • Sharma A, Mulloy D, Le L, Laubach V. NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. American journal of physiology. Lung cellular and molecular physiology. 2013;306(1): L69-79. PMID: 24186876 | PMCID: PMC3920214
  • Mulloy D, Stone M, Crosby I, Lapar D, Sharma A, Webb D, Lau C, Laubach V, Kron I. Ex vivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: delayed perfusion results in superior lung function. The Journal of thoracic and cardiovascular surgery. 2012;144(5): 1208-15. PMID: 22944084 | PMCID: PMC3477251
  • Lapar D, Hajzus V, Zhao Y, Lau C, French B, Kron I, Sharma A, Laubach V. Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. American journal of respiratory cell and molecular biology. 2011;46(3): 299-305. PMID: 21980055 | PMCID: PMC3326427
  • Sharma A, LaPar D, Zhao Y, Li L, Lau C, Kron I, Iwakura Y, Okusa M, Laubach V. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. American journal of respiratory and critical care medicine. 2011;183(11): 1539-49. PMID: 21317314 | PMCID: PMC3137143
  • Laubach V, French B, Okusa M. Targeting of adenosine receptors in ischemia-reperfusion injury. Expert opinion on therapeutic targets. 2010;15(1): 103-18. PMID: 21110787 | PMCID: PMC3075429
  • Sharma A, Linden J, Kron I, Laubach V. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respiratory research. 2009;10 58. PMID: 19558673 | PMCID: PMC2711962