Vesna Jevtovic-Todorovic

Education

  • MD, University of Belgrade School of Medicine
  • PhD, University of Illinois School of Medicine
  • Intern, Loyola University School of Medicine
  • Residency, Washington University
  • MBA, University of Virginia

Primary Appointment

  • Professor, Anesthesiology

Contact

Research Interest(s)

Mechanisms by which anesthetic drugs interact with neurotransmitter systems in the central nervous system to produce pharmacological and toxicological effects.

Research Description

Broadly, my research interests focus on mechanisms by which anesthetic drugs interact with neurotransmitter systems in the central nervous system to produce both pharmacological and toxicological effects. My primary interests thus far have centered on the identification and characterization of neurotoxic properties of commonly used intravenous and inhalational anesthetics with special emphasis on NMDA antagonist class of general anesthetics. It had extended to include several studies that have looked at the pharmacological ways of protection against this type of neurotoxicity. This research is federally funded by NIA/NIH.

Another important aspect of my research is focused on pathophysiology and pharmacology of the neuropathic pain using whole animal models and variety of neurobehavioral tests. This research is federally funded by NIDA/NIH.

Selected Publications

  • Rizzi S, Ori C, Jevtovic-Todorovic V. Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Annals of the New York Academy of Sciences. 2010;1199 43-51. PMID: 20633108
  • Lunardi N, Ori C, Erisir A, Jevtovic-Todorovic V. General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotoxicity research. 2009;17(2): 179-88. PMID: 19626389
  • Pesić V, Milanović D, Tanić N, Popić J, Kanazir S, Jevtović-Todorović V, Ruzdijić S. Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2009;27(3): 279-87. PMID: 19150648
  • Rizzi S, Carter L, Ori C, Jevtovic-Todorovic V. Clinical anesthesia causes permanent damage to the fetal guinea pig brain. Brain pathology (Zurich, Switzerland). 2008;18(2): 198-210. PMID: 18241241
  • Nikizad H, Yon J, Carter L, Jevtovic-Todorovic V. Early exposure to general anesthesia causes significant neuronal deletion in the developing rat brain. Annals of the New York Academy of Sciences. 2007;1122 69-82. PMID: 18077565
  • Jevtovic-Todorovic V, Carter L. The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain. Neurobiology of aging. 2005;26(6): 947-56. PMID: 15718054
  • Jevtovic-Todorovic V, Hartman R, Izumi Y, Benshoff N, Dikranian K, Zorumski C, Olney J, Wozniak D. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003;23(3): 876-82. PMID: 12574416
  • Jevtovic-Todorovic V, Wozniak D, Powell S, Olney J. Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex. Brain research. 2001;913(2): 185-9. PMID: 11549385
  • Jevtovic-Todorovic V, Benshoff N, Olney J. Ketamine potentiates cerebrocortical damage induced by the common anaesthetic agent nitrous oxide in adult rats. British journal of pharmacology. 2000;130(7): 1692-8. PMID: 10928976 | PMCID: PMC1572233
  • Jevtović-Todorović V, Todorović S, Mennerick S, Powell S, Dikranian K, Benshoff N, Zorumski C, Olney J. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature medicine. 1998;4(4): 460-3. PMID: 9546794
  • Jevtović-Todorović V, Kirby C, Olney J. Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1997;17(2): 168-74. PMID: 9040496