Our Faculty > Umesh S Deshmukh

Umesh S Deshmukh

Umesh S Deshmukh

Education

  • PhD, National Institute of Immunology

Primary Appointment

  • Associate Professor, Medicine- Nephrology

Contact

Research Interest(s)

Activation of Innate and Adaptive Immunity by Microbiota and it's role in autoimmune disorders.

Research Description

My laboratory is interested in investigating pathogenetic mechanisms of rheumatic autoimmune disorders, Systemic Lupus Erythematosus and Sjögren’s syndrome. While lupus is a multi organ disorder involving kidneys, skin, lungs and heart; Sjögren’s syndrome mainly affects the exocrine glands causing the dry eye and dry mouth symptoms. A common feature of both diseases is activation of self-reactive T and B cells, and generation of anti-nuclear autoantibodies. Recent literature clearly indicates that normal microbiota shapes an individuals immune repertoire. Currently the major emphasis of our research is on understanding how oral and gut microbiota contribute towards the initiation and amplification of autoimmune responses in Lupus and Sjögren’s syndrome. In addition to basic research, my laboratory also has a strong translational focus. In this regard, we are exploring the feasibility of therapeutic agents targeting GPCRs for treatment of autoimmunity and restoration organ function.

Selected Publications

  • Scindia Y, Deshmukh U, Thimmalapura P, Bagavant H. Anti-alpha8 integrin immunoliposomes in glomeruli of lupus-susceptible mice: a novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosus. Arthritis and rheumatism. 2008;58(12): 3884-91. PMID: 19035491 | PMCID: PMC2678908
  • Deshmukh U, Ohyama Y, Bagavant H, Guo X, Gaskin F, Fu S. Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 mice. Arthritis and rheumatism. 2008;58(5): 1318-23. PMID: 18438852 | PMCID: PMC2721328
  • Jiang C, Deshmukh U, Gaskin F, Bagavant H, Hanson J, David C, Fu S. Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens. Journal of immunology (Baltimore, Md. : 1950). 2009;184(2): 1085-91. PMID: 20007529 | PMCID: PMC2842881
  • Sim D, Bagavant H, Scindia Y, Ge Y, Gaskin F, Fu S, Deshmukh U. Genetic complementation results in augmented autoantibody responses to lupus-associated antigens. Journal of immunology (Baltimore, Md. : 1950). 2009;183(5): 3505-11. PMID: 19667095 | PMCID: PMC2837801
  • Sharma R, Deshmukh U, Zheng L, Fu S, Ju S. X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms. Journal of immunology (Baltimore, Md. : 1950). 2009;183(5): 3212-8. PMID: 19648271 | PMCID: PMC2735024
  • Deshmukh U, Nandula S, Thimmalapura P, Scindia Y, Bagavant H. Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2009;38(1): 42-7. PMID: 19192049 | PMCID: PMC2763314
  • Scindia Y, Deshmukh U, Bagavant H. Mesangial pathology in glomerular disease: targets for therapeutic intervention. Advanced drug delivery reviews. 2010;62(14): 1337-43. PMID: 20828589 | PMCID: PMC2992591
  • Deshmukh U, Sim D, Dai C, Kannapell C, Gaskin F, Rajagopalan G, David C, Fu S. HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD. Journal of autoimmunity. 2011;37(3): 254-62. PMID: 21868195 | PMCID: PMC3372418
  • Nandula S, Scindia Y, Dey P, Bagavant H, Deshmukh U. Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like disease. Oral diseases. 2011;17(8): 801-7. PMID: 21815968 | PMCID: PMC3192939
  • Bagavant H, Scindia Y, Nackiewicz D, Nandula S, Doran A, Cutchins A, Oldham S, Deshmukh U, McNamara C. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. The American journal of pathology. 2011;179(2): 651-60. PMID: 21801865 | PMCID: PMC3157169
  • Fu S, Deshmukh U, Gaskin F. Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR. Journal of autoimmunity. 2011;37(2): 104-12. PMID: 21632208 | PMCID: PMC3173577
  • Sharma R, Sung S, Ju C, Deshmukh U, Fu S, Ju S. Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fate. Journal of autoimmunity. 2011;37(2): 113-21. PMID: 21621978 | PMCID: PMC3173573
  • Bagavant H, Kalantarinia K, Scindia Y, Deshmukh U. Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practice. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2011;57(3): 498-507. PMID: 21239097 | PMCID: PMC3042497
  • Nandula S, Dey P, Corbin K, Nunemaker C, Bagavant H, Deshmukh U. Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2012. PMID: 22672212 | PMCID: PMC3443546