Ukpong Bassey Eyo

Education

  • BS, Northwest Missouri State
  • PhD, University of Iowa
  • Postdoc, Rutgers University, NJ
  • Postdoc, Mayo Clinic, Rochester, MN

Contact

Research Interest(s)

Neuroscience

Research Description

Microglia in neurodevelopment and neurodevelopment disorders

Selected Publications

  • Bosco D, Zheng J, Xu Z, Peng J, Eyo U, Tang K, Yan C, Huang J, Feng L, Wu G, Richardson J, Wang H, Wu L. RNAseq analysis of hippocampal microglia after kainic acid-induced seizures. Molecular brain. 2018;11(1): 34. PMID: 29925434 | PMCID: PMC6011524
  • Eyo U, Bispo A, Liu J, Sabu S, Wu R, DiBona V, Zheng J, Murugan M, Zhang H, Tang Y, Wu L. The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions. Scientific reports. 2018;8(1): 828. PMID: 29339791 | PMCID: PMC5770428
  • Eyo U, Mo M, Yi M, Murugan M, Liu J, Yarlagadda R, Margolis D, Xu P, Wu L. P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape. Cell reports. 2018;23(4): 959-966. PMID: 29694903 | PMCID: PMC5965271
  • Zhao X, Eyo U, Murugan M, Wu L. Microglial interactions with the neurovascular system in physiology and pathology. Developmental neurobiology. 2018;78(6): 604-617. PMID: 29318762 | PMCID: PMC5980686
  • Eyo U, Peng J, Murugan M, Mo M, Lalani A, Xie P, Xu P, Margolis D, Wu L. Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus. eNeuro. 2017;3(6). PMID: 28101527 | PMCID: PMC5237828
  • Tian D, Peng J, Murugan M, Feng L, Liu J, Eyo U, Zhou L, Mogilevsky R, Wang W, Wu L. Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017;37(33): 7878-7892. PMID: 28716963 | PMCID: PMC5559763
  • Eyo U, Murugan M, Wu L. Microglia-Neuron Communication in Epilepsy. Glia. 2016;65(1): 5-18. PMID: 27189853 | PMCID: PMC5116010
  • Gu N, Peng J, Murugan M, Wang X, Eyo U, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu L. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell reports. 2016;16(3): 605-14. PMID: 27373153 | PMCID: PMC4956495
  • Swiatkowski P, Murugan M, Eyo U, Wang Y, Rangaraju S, Oh S, Wu L. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience. 2016;318 22-33. PMID: 26791526 | PMCID: PMC4753827
  • Eyo U, Gu N, De S, Dong H, Richardson J, Wu L. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015;35(6): 2417-22. PMID: 25673836 | PMCID: PMC4323526
  • Eyo U, Miner S, Weiner J, Dailey M. Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus. Brain, behavior, and immunity. 2015;55 49-59. PMID: 26576723 | PMCID: PMC4864211
  • Gu N, Eyo U, Murugan M, Peng J, Matta S, Dong H, Wu L. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain, behavior, and immunity. 2015;55 82-92. PMID: 26576724 | PMCID: PMC4864135
  • Liu J, Tian D, Murugan M, Eyo U, Dreyfus C, Wang W, Wu L. Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. Journal of neurochemistry. 2015;135(2): 347-56. PMID: 26173779 | PMCID: PMC4721248
  • Eyo U, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu L. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014;34(32): 10528-40. PMID: 25100587 | PMCID: PMC4200107
  • Dailey M, Eyo U, Fuller L, Hass J, Kurpius D. Imaging microglia in brain slices and slice cultures. Cold Spring Harbor protocols. 2013;2013(12): 1142-8. PMID: 24298036
  • Eyo U, Dailey M. Microglia: key elements in neural development, plasticity, and pathology. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2013;8(3): 494-509. PMID: 23354784 | PMCID: PMC3657325
  • Eyo U, Miner S, Ahlers K, Wu L, Dailey M. P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. Neuropharmacology. 2013;73 311-9. PMID: 23770338 | PMCID: PMC3786777
  • Eyo U, Wu L. Bidirectional microglia-neuron communication in the healthy brain. Neural plasticity. 2013;2013 456857. PMID: 24078884 | PMCID: PMC3775394
  • Eyo U, Dailey M. Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues. Glia. 2012;60(11): 1747-60. PMID: 22847985 | PMCID: PMC3786781