- Biomedical Sciences Graduate Program | Todd Fox

Todd Fox

Contact

Research Interest(s)

Sphingolipids in ocular disease and cancer

Research Description

Sphingolipids in ocular disease and cancer

Selected Publications

  • Barth B, Shanmugavelandy S, Kaiser J, McGovern C, Altınoğlu E, Haakenson J, Hengst J, Gilius E, Knupp S, Fox T, Smith J, Ritty T, Adair J, Kester M. PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. ACS nano. 2013;7(3): 2132-44. PMID: 23373542 | PMCID: PMC3757127
  • Hankins J, Ward K, Linton S, Barth B, Stahelin R, Fox T, Kester M. Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex. The Journal of biological chemistry. 2013;288(27): 19726-38. PMID: 23696646 | PMCID: PMC3707677
  • Jones K, Kim P, Patel B, Kelsen S, Braverman A, Swinton D, Gafken P, Jones L, Lane W, Neveu J, Leung H, Shaffer S, Leszyk J, Stanley B, Fox T, Stanley A, Hall M, Hampel H, South C, de la Chapelle A, Burt R, Jones D, Kopelovich L, Yeung A. Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers. Journal of proteome research. 2013;12(10): 4351-65. PMID: 24004147 | PMCID: PMC3817719
  • Morad S, Levin J, Tan S, Fox T, Feith D, Cabot M. Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. Biochimica et biophysica acta. 2013;1831(12): 1657-64. PMID: 23939396
  • Ryland L, Doshi U, Shanmugavelandy S, Fox T, Aliaga C, Broeg K, Baab K, Young M, Khan O, Haakenson J, Jarbadan N, Liao J, Wang H, Feith D, Loughran T, Liu X, Kester M. C6-ceramide nanoliposomes target the warburg effect in chronic lymphocytic leukemia. PloS one. 2013;8(12): e84648. PMID: 24367685 | PMCID: PMC3868606
  • Fox T, Young M, Pedersen M, Han X, Gardner T, Kester M. Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death. Investigative ophthalmology & visual science. 2012;53(11): 7257-67. PMID: 22952117 | PMCID: PMC3478036
  • Watters R, Fox T, Tan S, Shanmugavelandy S, Choby J, Broeg K, Liao J, Kester M, Cabot M, Loughran T, Liu X. Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. Leukemia & lymphoma. 2012;54(6): 1288-96. PMID: 23181473
  • Hankins J, Fox T, Barth B, Unrath K, Kester M. Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression. The Journal of biological chemistry. 2011;286(52): 44357-66. PMID: 22065582 | PMCID: PMC3247944
  • Liao A, Broeg K, Fox T, Tan S, Watters R, Shah M, Zhang L, Li Y, Ryland L, Yang J, Aliaga C, Dewey A, Rogers A, Loughran K, Hirsch L, Jarbadan N, Baab K, Liao J, Wang H, Kester M, Desai D, Amin S, Loughran T, Liu X. Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. Blood. 2011;118(10): 2793-800. PMID: 21768294 | PMCID: PMC3172796
  • Ryland L, Fox T, Liu X, Loughran T, Kester M. Dysregulation of sphingolipid metabolism in cancer. Cancer biology & therapy. 2011;11(2): 138-49. PMID: 21209555