Timothy N. Bullock

Education

  • PhD, Thomas Jefferson University

Primary Appointment

  • Associate Professor, Pathology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • IL-27 and the generation of CD8+ T-cell responses to peptide vaccines. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(47): 16639-40. PMID: 25404318
  • Dong H, Bullock T. Metabolic influences that regulate dendritic cell function in tumors. Frontiers in immunology. 2014;5 24. PMID: 24523723 | PMCID: PMC3906600
  • Dong H, Franklin N, Roberts D, Yagita H, Glennie M, Bullock T. CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help. Journal of immunology (Baltimore, Md. : 1950). 2012;188(8): 3829-38. PMID: 22422886 | PMCID: PMC3326605
  • Stadnisky M, Xie X, Coats E, Bullock T, Brown M. Self MHC class I-licensed NK cells enhance adaptive CD8 T-cell viral immunity. Blood. 2011;117(19): 5133-41. PMID: 21436069 | PMCID: PMC3109538
  • Roberts D, Franklin N, Kingeter L, Yagita H, Tutt A, Glennie M, Bullock T. Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells. Journal of immunotherapy (Hagerstown, Md. : 1997). 2010;33(8): 769-79. PMID: 20842060 | PMCID: PMC2955154
  • Van Deusen K, Rajapakse R, Bullock T. CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses. Journal of leukocyte biology. 2009;87(3): 477-85. PMID: 19952354 | PMCID: PMC2830127
  • Ferguson A, Nichols L, Zarling A, Thompson E, Brinkman C, Hargadon K, Bullock T, Engelhard V. Strategies and challenges in eliciting immunity to melanoma. Immunological reviews. 2008;222 28-42. PMID: 18363993 | PMCID: PMC2882710
  • Hwang M, Lukens J, Bullock T. Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Journal of immunology (Baltimore, Md. : 1950). 2007;179(9): 5829-38. PMID: 17947656
  • Hargadon K, Brinkman C, Sheasley-O'neill S, Nichols L, Bullock T, Engelhard V. Incomplete differentiation of antigen-specific CD8 T cells in tumor-draining lymph nodes. Journal of immunology (Baltimore, Md. : 1950). 2006;177(9): 6081-90. PMID: 17056534
  • Slingluff C, Chianese-Bullock K, Bullock T, Grosh W, Mullins D, Nichols L, Olson W, Petroni G, Smolkin M, Engelhard V. Immunity to melanoma antigens: from self-tolerance to immunotherapy. Advances in immunology. 2006;90 243-95. PMID: 16730266