Thurl E Harris


  • PhD, Baylor College of Medicine

Primary Appointment

  • Assistant Professor, Pharmacology


Research Interest(s) comprar viagra en alexandria va usa

Research Description

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Selected Publications

  • Eaton J, Takkellapati S, Lawrence R, McQueeney K, Boroda S, Mullins G, Sherwood S, Finck B, Villén J, Harris T. Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation. The Journal of biological chemistry. 2014;289(26): 18055-66. PMID: 24811178 | PMCID: PMC4140300
  • Mullins G, Wang L, Raje V, Sherwood S, Grande R, Boroda S, Eaton J, Blancquaert S, Roger P, Leitinger N, Harris T. Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes. Proceedings of the National Academy of Sciences of the United States of America. 2014. PMID: 25422441
  • Creutz C, Eaton J, Harris T. Assembly of high molecular weight complexes of lipin on a supported lipid bilayer observed by atomic force microscopy. Biochemistry. 2013;52(30): 5092-102. PMID: 23862673 | PMCID: PMC4041088
  • Dominguez C, Floyd D, Xiao A, Mullins G, Kefas B, Xin W, Yacur M, Abounader R, Lee J, Wilson G, Harris T, Purow B. Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers. Cancer discovery. 2013;3(7): 782-97. PMID: 23558954 | PMCID: PMC3710531
  • Eaton J, Mullins G, Brindley D, Harris T. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association. The Journal of biological chemistry. 2013;288(14): 9933-45. PMID: 23426360 | PMCID: PMC3617293
  • Zhang C, Wendel A, Keogh M, Harris T, Chen J, Coleman R. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(5): 1667-72. PMID: 22307628 | PMCID: PMC3277174
  • Peterson T, Sengupta S, Harris T, Carmack A, Kang S, Balderas E, Guertin D, Madden K, Carpenter A, Finck B, Sabatini D. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011;146(3): 408-20. PMID: 21816276 | PMCID: PMC3336367
  • Kim H, Kumar A, Wang L, Liu G, Keller S, Lawrence J, Finck B, Harris T. Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Molecular and cellular biology. 2010;30(12): 3126-39. PMID: 20385772 | PMCID: PMC2876672
  • Kumar A, Lawrence J, Jung D, Ko H, Keller S, Kim J, Magnuson M, Harris T. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes. 2010;59(6): 1397-406. PMID: 20332342 | PMCID: PMC2874700
  • Liu G, Qu J, Carmack A, Kim H, Chen C, Ren H, Morris A, Finck B, Harris T. Lipin proteins form homo- and hetero-oligomers. The Biochemical journal. 2010;432(1): 65-76. PMID: 20735359 | PMCID: PMC3117669