Thomas P Loughran, Jr.

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Research Interest(s)

Hematologic Malignancies

Research Description

My career as a physician scientist has been a testament to translational research – with clinical observations leading to discoveries in the laboratory and laboratory research contributing to improved clinical treatments. Indeed, the circular route of bedside to bench to bedside has been the foundation of my career. I have been instrumental in discovering/delineating several hematologic malignancies including discovery of large granular lymphocyte (LGL) leukemia (Ann Intern Med 102:169,1985); characterization of intestinal lymphomas associated with celiac disease as T cell lymphomas rather than malignant histiocytosis (Ann Intern Med 104:44, 1986); discovery of CD4+ NK leukemias (now recognized as a dendritic-cell neoplasms, Cancer 75:2474, 1995); and delineation of T cell from NK cell type of LGL leukemia (Blood 82:1, 1993).

Selected Publications

  • Aumiller B, Parrott R, Lengerich E, Dominic O, Camacho F, Lehman E, Gallant N, Loughran T. Responses to a Theoretically Adapted Clinical Trial Education Session: Faith-Based Sites Versus Rural Work Site Dissemination. Journal of cancer education : the official journal of the American Association for Cancer Education. 2013. PMID: 23884547
  • Chloros G, Haar P, Loughran T, Hayes C. Imaging of glenoid labrum lesions. Clinics in sports medicine. 2013;32(3): 361-90. PMID: 23773873
  • Jerez A, Clemente M, Makishima H, Rajala H, Gómez-Seguí I, Olson T, McGraw K, Przychodzen B, Kulasekararaj A, Afable M, Husseinzadeh H, Hosono N, Leblanc F, Lagström S, Zhang D, Ellonen P, Tichelli A, Nissen C, Lichtin A, Wodnar-Filipowicz A, Mufti G, List A, Mustjoki S, Loughran T, Maciejewski J. STAT3-mutations indicate the presence of subclinical T cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients. Blood. 2013. PMID: 23926297
  • LeBlanc F, Hasanali Z, Loughran T. Does IL-15 have a causative role in large granular lymphocyte leukemia? Immunotherapy. 2013;5(3): 231-4. PMID: 23444952
  • Rajala H, Eldfors S, Kuusanmäki H, van Adrichem A, Olson T, Lagström S, Andersson E, Jerez A, Clemente M, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski J, Loughran T, Heckman C, Mustjoki S. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood. 2013;121(22): 4541-50. PMID: 23596048 | PMCID: PMC3668487
  • Shah M, Barochia A, Loughran T. Impact of genetic targets on cancer therapy in acute myelogenous leukemia. Advances in experimental medicine and biology. 2013;779 405-37. PMID: 23288651
  • Steinway S, Loughran T. Targeting IL-15 in large granular lymphocyte leukemia. Expert review of clinical immunology. 2013;9(5): 405-8. PMID: 23634735
  • Doi K, Li R, Sung S, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran T, Sebti S, Wang H. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. The Journal of biological chemistry. 2012;287(13): 10224-35. PMID: 22311987 | PMCID: PMC3323047
  • Jerez A, Clemente M, Makishima H, Koskela H, Leblanc F, Peng Ng K, Olson T, Przychodzen B, Afable M, Gomez-Segui I, Guinta K, Durkin L, Hsi E, McGraw K, Zhang D, Wlodarski M, Porkka K, Sekeres M, List A, Mustjoki S, Loughran T, Maciejewski J. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood. 2012;120(15): 3048-57. PMID: 22859607 | PMCID: PMC3471515
  • Koskela H, Eldfors S, Ellonen P, van Adrichem A, Kuusanmäki H, Andersson E, Lagström S, Clemente M, Olson T, Jalkanen S, Majumder M, Almusa H, Edgren H, Lepistö M, Mattila P, Guinta K, Koistinen P, Kuittinen T, Penttinen K, Parsons A, Knowles J, Saarela J, Wennerberg K, Kallioniemi O, Porkka K, Loughran T, Heckman C, Maciejewski J, Mustjoki S. Somatic STAT3 mutations in large granular lymphocytic leukemia. The New England journal of medicine. 2012;366(20): 1905-13. PMID: 22591296 | PMCID: PMC3693860
  • Leblanc F, Zhang D, Liu X, Loughran T. Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets. Future oncology (London, England). 2012;8(7): 787-801. PMID: 22830400 | PMCID: PMC3464048
  • Mailloux A, Sugimori C, Komrokji R, Yang L, Maciejewski J, Sekeres M, Paquette R, Loughran T, List A, Epling-Burnette P. Expansion of effector memory regulatory T cells represents a novel prognostic factor in lower risk myelodysplastic syndrome. Journal of immunology (Baltimore, Md. : 1950). 2012;189(6): 3198-208. PMID: 22875800 | PMCID: PMC3436939
  • Nyland S, Krissinger D, Clemente M, Irby R, Baab K, Jarbadan N, Sokol L, Schaefer E, Liao J, Cuthbertson D, Epling-Burnette P, Paquette R, List A, Maciejewski J, Loughran T. Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study. Leukemia research. 2012;36(5): 581-7. PMID: 22386729 | PMCID: PMC3312981
  • Ren T, Dong W, Takahashi Y, Xiang D, Yuan Y, Liu X, Loughran T, Sun S, Wang H, Cheng H. HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy. The Journal of biological chemistry. 2012;287(41): 34683-93. PMID: 22891252 | PMCID: PMC3464572
  • Thomas K, Loughran T, Piquero A. Do individual characteristics explain variation in sanction risk updating among serious juvenile offenders? Advancing the logic of differential deterrence. Law and human behavior. 2012;37(1): 10-21. PMID: 22449003
  • Watters R, Fox T, Tan S, Shanmugavelandy S, Choby J, Broeg K, Liao J, Kester M, Cabot M, Loughran T, Liu X. Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. Leukemia & lymphoma. 2012;54(6): 1288-96. PMID: 23181473
  • Watters R, Kester M, Tran M, Loughran T, Liu X. Development and use of ceramide nanoliposomes in cancer. Methods in enzymology. 2012;508 89-108. PMID: 22449922
  • Watters R, Loughran T. Diagnosing large granular lymphocyte leukemia is bloody difficult. Leukemia & lymphoma. 2012;54(2): 438-9. PMID: 23025294
  • Yang L, Mailloux A, Rollison D, Painter J, Maciejewski J, Paquette R, Loughran T, McGraw K, Makishima H, Radhakrishnan R, Wei S, Ren X, Komrokji R, List A, Epling-Burnette P. Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency. Leukemia. 2012;27(4): 897-906. PMID: 23072779
  • Yang S, Mulvey E, Loughran T, Hanusa B. Psychiatric symptoms and alcohol use in community violence by persons with a psychotic disorder or depression. Psychiatric services (Washington, D.C.). 2012;63(3): 262-9. PMID: 22388531 | PMCID: NIHMS369215
  • Zhang D, Loughran T. Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2012;2012 652-9. PMID: 23233648
  • Bai F, Villagra A, Zou J, Painter J, Connolly K, Blaskovich M, Sokol L, Sebti S, Djeu J, Loughran T, Wei S, Sotomayor E, Epling-Burnette P. Tipifarnib-mediated suppression of T-bet-dependent signaling pathways. Cancer immunology, immunotherapy : CII. 2011;61(4): 523-33. PMID: 21983879
  • Barth B, I Altinoğlu E, Shanmugavelandy S, Kaiser J, Crespo-Gonzalez D, DiVittore N, McGovern C, Goff T, Keasey N, Adair J, Loughran T, Claxton D, Kester M. Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia. ACS nano. 2011;5(7): 5325-37. PMID: 21675727
  • Campbell C, Zhang R, Haley J, Liu X, Loughran T, Schell T, Albert R, Thakar J. Why Do CD8+ T Cells become Indifferent to Tumors: A Dynamic Modeling Approach. Frontiers in physiology. 2011;2 32. PMID: 21808621 | PMCID: PMC3135868
  • Clemente M, Wlodarski M, Makishima H, Viny A, Bretschneider I, Shaik M, Bejanyan N, Lichtin A, Hsi E, His E, Paquette R, Loughran T, Maciejewski J. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011;118(16): 4384-93. PMID: 21865345 | PMCID: PMC3204910
  • El-Bayoumy K, Das A, Russell S, Wolfe S, Jordan R, Renganathan K, Loughran T, Somiari R. The effect of selenium enrichment on baker's yeast proteome. Journal of proteomics. 2011;75(3): 1018-30. PMID: 22067702 | PMCID: PMC3246083
  • Iselin A, Mulvey E, Loughran T, Chung H, Schubert C. A longitudinal examination of serious adolescent offenders' perceptions of chances for success and engagement in behaviors accomplishing goals. Journal of abnormal child psychology. 2011;40(2): 237-49. PMID: 21881855 | PMCID: PMC3268865
  • Liao A, Broeg K, Fox T, Tan S, Watters R, Shah M, Zhang L, Li Y, Ryland L, Yang J, Aliaga C, Dewey A, Rogers A, Loughran K, Hirsch L, Jarbadan N, Baab K, Liao J, Wang H, Kester M, Desai D, Amin S, Loughran T, Liu X. Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. Blood. 2011;118(10): 2793-800. PMID: 21768294 | PMCID: PMC3172796
  • Liu X, Loughran T. The spectrum of large granular lymphocyte leukemia and Felty's syndrome. Current opinion in hematology. 2011;18(4): 254-9. PMID: 21546829
  • Loughran T, Wang H. Editorial [hot topic: Therapeutic targeting of the sphingolipid "biostat" in hematologic malignancies (guest editors: Thomas P. Loughran and Hong-Gang Wang)]. Anti-cancer agents in medicinal chemistry. 2011;11(9): 780-1. PMID: 22023044
  • Ryland L, Fox T, Liu X, Loughran T, Kester M. Dysregulation of sphingolipid metabolism in cancer. Cancer biology & therapy. 2011;11(2): 138-49. PMID: 21209555
  • Saadatpour A, Wang R, Liao A, Liu X, Loughran T, Albert I, Albert R. Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. PLoS computational biology. 2011;7(11): e1002267. PMID: 22102804 | PMCID: PMC3213185
  • Watters R, Liu X, Loughran T. T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias. Leukemia & lymphoma. 2011;52(12): 2217-25. PMID: 21749307 | PMCID: PMC3721966
  • Watters R, Wang H, Sung S, Loughran T, Liu X. Targeting sphingosine-1-phosphate receptors in cancer. Anti-cancer agents in medicinal chemistry. 2011;11(9): 810-7. PMID: 21707490 | PMCID: PMC3698949
  • Yang J, Loughran T. Potential clinical application of imatinib mesylate in patients with leukemic large granular lymphocytes. Leukemia & lymphoma. 2011;52(10): 1834-5. PMID: 21699458
  • Yu J, Mitsui T, Wei M, Mao H, Butchar J, Shah M, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G, Benson D, Loughran T, Tridandapani S, Caligiuri M. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. The Journal of clinical investigation. 2011;121(4): 1456-70. PMID: 21364281 | PMCID: PMC3069763
  • Zhang R, Loughran T. Off-target effects of tyrosine kinase inhibitors: Beauty or the Beast? Leukemia & lymphoma. 2011;52(4): 556-7. PMID: 21438827
  • Shell shock, trauma, and the First World War: the making of a diagnosis and its histories. Journal of the history of medicine and allied sciences. 2010;67(1): 94-119. PMID: 20713494
  • Abbi K, Rizvi S, Sivik J, Thyagarajan S, Loughran T, Drabick J. Guillain-Barré syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. Leukemia research. 2010;34(7): e154-6. PMID: 20362332
  • Epling-Burnette P, Loughran T. Suppression of farnesyltransferase activity in acute myeloid leukemia and myelodysplastic syndrome: current understanding and recommended use of tipifarnib. Expert opinion on investigational drugs. 2010;19(5): 689-98. PMID: 20402600 | PMCID: PMC3252817
  • Iqbal J, Weisenburger D, Chowdhury A, Tsai M, Srivastava G, Greiner T, Kucuk C, Deffenbacher K, Vose J, Smith L, Au W, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Ko Y, Sng I, Liu X, Loughran T, Armitage J, Chan W. Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro. Leukemia. 2010;25(2): 348-58. PMID: 21052088
  • Lamy T, Loughran T. How I treat LGL leukemia. Blood. 2010;117(10): 2764-74. PMID: 21190991 | PMCID: PMC3062292
  • Liu X, Ryland L, Yang J, Liao A, Aliaga C, Watts R, Tan S, Kaiser J, Shanmugavelandy S, Rogers A, Loughran K, Petersen B, Yuen J, Meng F, Baab K, Jarbadan N, Broeg K, Zhang R, Liao J, Sayers T, Kester M, Loughran T. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Blood. 2010;116(20): 4192-201. PMID: 20671121 | PMCID: PMC2993625
  • Loughran T, Mulvey E, Schubert C, Chassin L, Steinberg L, Piquero A, Fagan J, Cota-Robles S, Cauffman E, Losoya S. Differential effects of adult court transfer on juvenile offender recidivism. Law and human behavior. 2010;34(6): 476-88. PMID: 20195895 | PMCID: PMC2901422
  • Loughran T, Mulvey E, Schubert C, Fagan J, Piquero A, Losoya S. ESTIMATING A DOSE-RESPONSE RELATIONSHIP BETWEEN LENGTH OF STAY AND FUTURE RECIDIVISM IN SERIOUS JUVENILE OFFENDERS. Criminology; an interdisciplinary journal. 2010;47(3): 699-740. PMID: 20052309 | PMCID: PMC2801446
  • Pastor D, Eggers A, Drabick J, Loughran T, Bayerl M, Shope T. Retroperitoneal diffuse large B-cell lymphoma presenting as pseudoachalasia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010;28(12): e184-7. PMID: 20231681
  • Schubert C, Mulvey E, Loughran T, Fagan J, Chassin L, Piquero A, Losoya S, Steinberg L, Cauffman E. Predicting outcomes for youth transferred to adult court. Law and human behavior. 2010;34(6): 460-75. PMID: 20204478
  • Sekeres M, List A, Cuthbertson D, Paquette R, Ganetzky R, Ganetsky R, Latham D, Paulic K, Afable M, Saba H, Loughran T, Maciejewski J. Phase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010;28(13): 2253-8. PMID: 20354132 | PMCID: PMC2860439
  • Sokol L, Loughran T. Large granular lymphocyte leukemia. Current hematologic malignancy reports. 2010;2(4): 278-82. PMID: 20425381
  • Takahashi Y, Meyerkord C, Hori T, Runkle K, Fox T, Kester M, Loughran T, Wang H. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. Autophagy. 2010;7(1): 61-73. PMID: 21068542 | PMCID: PMC3039731
  • Talamo G, Barochia A, Zangari M, Loughran T. Multiple myeloma presenting as CEA-producing rectal cancer. Rare tumors. 2010;2(1): e4. PMID: 21139949 | PMCID: PMC2994484
  • Talamo G, Farooq U, Zangari M, Liao J, Dolloff N, Loughran T, Epner E. Beyond the CRAB symptoms: a study of presenting clinical manifestations of multiple myeloma. Clinical lymphoma, myeloma & leukemia. 2010;10(6): 464-8. PMID: 21156463
  • Thomas A, Perzova R, Abbott L, Benz P, Poiesz M, Dube S, Loughran T, Ferrer J, Sheremata W, Glaser J, Leon-Ponte M, Poiesz B. LGL leukemia and HTLV. AIDS research and human retroviruses. 2010;26(1): 33-40. PMID: 20047475
  • Wozney J, Damluji A, Ahmed F, Zangari M, Loughran T, Talamo G. Estimation of daily proteinuria in patients with multiple myeloma by using the protein-to-creatinine ratio in random urine samples. Acta haematologica. 2010;123(4): 226-9. PMID: 20424436
  • Hysteria and neurasthenia in pre-1914 British medical discourse and in histories of shell-shock. History of psychiatry. 2009;19(73): 25-46. PMID: 19127827
  • Hodge D, Yang J, Buschman M, Schaughency P, Dang H, Bere W, Yang Y, Savan R, Subleski J, Yin X, Loughran T, Young H. Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemias. Cancer research. 2009;69(9): 3986-94. PMID: 19366803 | PMCID: PMC2786937
  • Nyland S, Loughran T. Putting HIV-1 apoptosis mediators to work against cancer: a killer job, with benefits. Cancer biology & therapy. 2009;8(2): 188-91. PMID: 19182513
  • Shah M, Zhang R, Loughran T. Never say die: survival signaling in large granular lymphocyte leukemia. Clinical lymphoma & myeloma. 2009;9 S244-53. PMID: 19778848
  • Yang J, Liu X, Nyland S, Zhang R, Ryland L, Broeg K, Baab K, Jarbadan N, Irby R, Loughran T. Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway. Blood. 2009;115(1): 51-60. PMID: 19880494 | PMCID: PMC2803691
  • Zhang R, Shah M, Loughran T. The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders. Hematological oncology. 2009;28(3): 105-17. PMID: 19645074
  • Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter J, Liu J, Sallman D, Chen Y, Yoder J, Djeu J, Loughran T, Epling-Burnette P, Wei S. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood. 2008;113(14): 3226-34. PMID: 19075187 | PMCID: PMC2665892
  • Epling-Burnette P, Sokol L, Chen X, Bai F, Zhou J, Blaskovich M, Zou J, Painter J, Edwards T, Moscinski L, Yoder J, Djeu J, Sebti S, Loughran T, Wei S. Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling. Blood. 2008;112(12): 4694-8. PMID: 18791165 | PMCID: PMC2597136
  • Shah M, Zhang R, Irby R, Kothapalli R, Liu X, Arrington T, Frank B, Lee N, Loughran T. Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood. 2008;112(3): 770-81. PMID: 18477771 | PMCID: PMC2481553
  • Viny A, Lichtin A, Pohlman B, Loughran T, Maciejewski J. Chronic B-cell dyscrasias are an important clinical feature of T-LGL leukemia. Leukemia & lymphoma. 2008;49(5): 932-8. PMID: 18452068
  • Bourgault-Rouxel A, Loughran T, Zambello R, Epling-Burnette P, Semenzato G, Donadieu J, Amiot L, Fest T, Lamy T. Clinical spectrum of gammadelta+ T cell LGL leukemia: analysis of 20 cases. Leukemia research. 2007;32(1): 45-8. PMID: 17544120
  • Lai D, Loughran T, Maciejewski J, Sasu S, Song S, Epling-Burnette P, Paquette R. Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. Leukemia research. 2007;32(5): 823-7. PMID: 17915315 | PMCID: NIHMS43485
  • Thomas J, Haseman J, Goodman J, Ward J, Loughran T, Spencer P. A review of large granular lymphocytic leukemia in Fischer 344 rats as an initial step toward evaluating the implication of the endpoint to human cancer risk assessment. Toxicological sciences : an official journal of the Society of Toxicology. 2007;99(1): 3-19. PMID: 17522071
  • Yang J, Epling-Burnette P, Painter J, Zou J, Bai F, Wei S, Loughran T. Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia. Blood. 2007;111(3): 1610-6. PMID: 17993614 | PMCID: PMC2214759
  • Burks E, Loughran T. Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. Blood reviews. 2006;20(5): 245-66. PMID: 16530306
  • Sokol L, Loughran T. Large granular lymphocyte leukemia. The oncologist. 2006;11(3): 263-73. PMID: 16549811
  • Hellmich B, Pinals R, Loughran T, Sullivan K. New clues to accrue on neutropenia in rheumatoid arthritis. Clinical immunology (Orlando, Fla.). 2005;117(1): 1-5. PMID: 16000259
  • Kothapalli R, Nyland S, Kusmartseva I, Bailey R, McKeown T, Loughran T. Constitutive production of proinflammatory cytokines RANTES, MIP-1beta and IL-18 characterizes LGL leukemia. International journal of oncology. 2005;26(2): 529-35. PMID: 15645140
  • Neelapu S, Gause B, Nikcevich D, Schuster S, Winter J, Gockerman J, Loughran T, Takeshita K, Inghirami G, McGaughey D, Watson T, Snow S, Kubovic P, Ferraro M, Jones E, Jaffe E, Schwartzentruber D, Danforth D, Sherry R, Kass E, Van Waes C, Reynolds C, Kwak L. Phase III randomized trial of patient-specific vaccination for previously untreated patients with follicular lymphoma in first complete remission: protocol summary and interim report. Clinical lymphoma. 2005;6(1): 61-4. PMID: 15989711
  • Sokol L, Agrawal D, Loughran T. Characterization of HTLV envelope seroreactivity in large granular lymphocyte leukemia. Leukemia research. 2005;29(4): 381-7. PMID: 15725471
  • Wlodarski M, O'Keefe C, Howe E, Risitano A, Rodriguez A, Warshawsky I, Loughran T, Maciejewski J. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood. 2005;106(8): 2769-80. PMID: 15914562
  • Berliner N, Horwitz M, Loughran T. Congenital and acquired neutropenia. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2004; 63-79. PMID: 15561677
  • Burks E, Loughran T. Perspectives in the treatment of LGL leukemia. Leukemia research. 2004;29(2): 123-5. PMID: 15607357
  • Epling-Burnette P, Bai F, Wei S, Chaurasia P, Painter J, Olashaw N, Hamilton A, Sebti S, Djeu J, Loughran T. ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL). Oncogene. 2004;23(57): 9220-9. PMID: 15516985
  • Epling-Burnette P, Painter J, Chaurasia P, Bai F, Wei S, Djeu J, Loughran T. Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood. 2004;103(9): 3431-9. PMID: 14726391