Thomas J. Braciale


  • BS, St. Joseph's College, Philadelphia, PA
  • MD, Univ. of Pennsylvania, Philadelphia, PA
  • PhD, Univ. of Pennsylvania, Philadelphia, PA
  • Residency, Barnes Hospital (Washington Univ.) St. Louis, MO
  • Postdoc, Australian National University, Canberra, Australia

Primary Appointment

  • Professor, Pathology


Research Interest(s)

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Selected Publications

  • Kim T, Gorski S, Hahn S, Murphy K, Braciale T. Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8(+) T Cell Differentiation by a CD24-Dependent Mechanism. Immunity. 2014;40(3): 400-13. PMID: 24631155
  • Gorski S, Hahn Y, Braciale T. Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection. PLoS pathogens. 2013;9(9): e1003615. PMID: 24068930 | PMCID: PMC3777868
  • Braciale T, Sun J, Kim T. Regulating the adaptive immune response to respiratory virus infection. Nature reviews. Immunology. 2012;12(4): 295-305. PMID: 22402670 | PMCID: PMC3364025
  • Gorski S, Hufford M, Braciale T. Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract. Current opinion in virology. 2012;2(3): 233-41. PMID: 22608464 | PMCID: PMC3378727
  • Hufford M, Richardson G, Zhou H, Manicassamy B, García-Sastre A, Enelow R, Braciale T. Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8(+) T Cells. PloS one. 2012;7(10): e46581. PMID: 23056353 | PMCID: PMC3466305
  • Kennedy J, Turner R, Braciale T, Heymann P, Borish L. Pathogenesis of rhinovirus infection. Current opinion in virology. 2012;2(3): 287-93. PMID: 22542099 | PMCID: PMC3378761
  • Yoo J, Fish E, Braciale T. LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection. The Journal of experimental medicine. 2012;209(10): 1853-67. PMID: 22987801 | PMCID: PMC3457726
  • Braciale T, Kim T. Slowing down with age: lung DCs do it too. The Journal of clinical investigation. 2011;121(12): 4636-9. PMID: 22105176 | PMCID: PMC3226069
  • Kim T, Sun J, Braciale T. T cell responses during influenza infection: getting and keeping control. Trends in immunology. 2011;32(5): 225-31. PMID: 21435950 | PMCID: PMC3090469
  • Sun J, Cardani A, Sharma A, Laubach V, Jack R, Müller W, Braciale T. Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus. PLoS pathogens. 2011;7(8): e1002173. PMID: 21829368 | PMCID: PMC3150291
  • Sun J, Dodd H, Moser E, Sharma R, Braciale T. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nature immunology. 2011;12(4): 327-34. PMID: 21297642 | PMCID: PMC3079402
  • Hufford M, Kim T, Sun J, Braciale T. Antiviral CD8+ T cell effector activities in situ are regulated by target cell type. The Journal of experimental medicine. 2010;208(1): 167-80. PMID: 21187318 | PMCID: PMC3023137
  • Kim T, Hufford M, Sun J, Fu Y, Braciale T. Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. The Journal of experimental medicine. 2010;207(6): 1161-72. PMID: 20513748 | PMCID: PMC2882836
  • Ream R, Sun J, Braciale T. Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis. Journal of immunology (Baltimore, Md. : 1950). 2010;184(5): 2401-9. PMID: 20139280 | PMCID: PMC2996134
  • Kim T, Braciale T. Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses. PloS one. 2009;4(1): e4204. PMID: 19145246 | PMCID: PMC2615220
  • Stevens W, Sun J, Castillo J, Braciale T. Pulmonary eosinophilia is attenuated by early responding CD8(+) memory T cells in a murine model of RSV vaccine-enhanced disease. Viral immunology. 2009;22(4): 243-51. PMID: 19594395 | PMCID: PMC2885249
  • Sun J, Madan R, Karp C, Braciale T. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nature medicine. 2009;15(3): 277-84. PMID: 19234462 | PMCID: PMC2693210
  • Hao X, Kim T, Braciale T. Differential response of respiratory dendritic cell subsets to influenza virus infection. Journal of virology. 2008;82(10): 4908-19. PMID: 18353940 | PMCID: PMC2346724
  • Wissinger E, Stevens W, Varga S, Braciale T. Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection. Journal of immunology (Baltimore, Md. : 1950). 2008;180(5): 2957-66. PMID: 18292518 | PMCID: PMC2855534
  • Stevens W, Kim T, Pujanauski L, Hao X, Braciale T. Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. Journal of immunological methods. 2007;327(1): 63-74. PMID: 17716680 | PMCID: PMC2670191
  • Yoon H, Legge K, Sung S, Braciale T. Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection. Journal of immunology (Baltimore, Md. : 1950). 2007;179(1): 391-9. PMID: 17579060