Tarek A. Abbas

Education

  • BA, Hunter College, City University of New York, NY
  • MA, Hunter College, City University of New York, NY
  • MPH, The Graduate Center, (CUNY), NY
  • PhD, City University of New York, Hunter College

Primary Appointment

  • Assistant Professor, Radiation Oncology

Contact

Research Interest(s)

The Ubiquitin System and Human Cancer

Research Description

Selected Publications

  • Abbas T, Keaton M, Dutta A. Genomic instability in cancer. Cold Spring Harbor perspectives in biology. 2013;5(3): a012914. PMID: 23335075 | PMCID: PMC3578360
  • Abbas T, Keaton M, Dutta A. Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. Cell cycle (Georgetown, Tex.). 2013;12(14): 2175-82. PMID: 23892434 | PMCID: PMC3755067
  • Abbas T, Mueller A, Shibata E, Keaton M, Rossi M, Dutta A. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. Molecular cell. 2013;49(6): 1147-58. PMID: 23478445 | PMCID: PMC3615078
  • Park J, Long D, Lee K, Abbas T, Shibata E, Negishi M, Luo Y, Schimenti J, Gambus A, Walter J, Dutta A. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Molecular and cellular biology. 2013;33(8): 1632-44. PMID: 23401855 | PMCID: PMC3624244
  • Terai K, Shibata E, Abbas T, Dutta A. Degradation of p12 Subunit by CRL4Cdt2 E3 Ligase Inhibits Fork Progression after DNA Damage. The Journal of biological chemistry. 2013;288(42): 30509-14. PMID: 24022480 | PMCID: PMC3798521
  • Abbas T, Dutta A. CRL4Cdt2: master coordinator of cell cycle progression and genome stability. Cell cycle (Georgetown, Tex.). 2011;10(2): 241-9. PMID: 21212733 | PMCID: PMC3025761
  • Shibata E, Abbas T, Huang X, Wohlschlegel J, Dutta A. Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Molecular and cellular biology. 2011;31(15): 3136-45. PMID: 21628527 | PMCID: PMC3147600
  • Van Rechem C, Black J, Abbas T, Allen A, Rinehart C, Yuan G, Dutta A, Whetstine J. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. The Journal of biological chemistry. 2011;286(35): 30462-70. PMID: 21757720 | PMCID: PMC3162406
  • Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A. CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Molecular cell. 2010;40(1): 9-21. PMID: 20932471 | PMCID: PMC2966975
  • Terai K, Abbas T, Jazaeri A, Dutta A. CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. Molecular cell. 2010;37(1): 143-9. PMID: 20129063 | PMCID: PMC2818832
  • Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nature reviews. Cancer. 2009;9(6): 400-14. PMID: 19440234 | PMCID: PMC2722839
  • Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes & development. 2008;22(18): 2496-506. PMID: 18794347 | PMCID: PMC2546691
  • Abbas T, Jha S, Sherman N, Dutta A. Autocatalytic phosphorylation of CDK2 at the activating Thr160. Cell cycle (Georgetown, Tex.). 2007;6(7): 843-52. PMID: 17361108
  • Abbas T, Dutta A. CDK2-activating kinase (CAK): more questions than answers. Cell cycle (Georgetown, Tex.). 2006;5(10): 1123-4. PMID: 16687928
  • Sivaprasad U, Abbas T, Dutta A. Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. Molecular cancer therapeutics. 2006;5(9): 2310-6. PMID: 16985065
  • Hui L, Abbas T, Pielak R, Joseph T, Bargonetti J, Foster D. Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Molecular and cellular biology. 2004;24(13): 5677-86. PMID: 15199126 | PMCID: PMC480910
  • Abbas T, White D, Hui L, Yoshida K, Foster D, Bargonetti J. Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta. The Journal of biological chemistry. 2003;279(11): 9970-7. PMID: 14699137
  • Abbas T, Olivier M, Lopez J, Houser S, Xiao G, Kumar G, Tomasz M, Bargonetti J. Differential activation of p53 by the various adducts of mitomycin C. The Journal of biological chemistry. 2002;277(43): 40513-9. PMID: 12183457