Susanna R. Keller


  • MD, University of Zurich

Primary Appointment

  • Associate Professor, Medicine- Endocrinology and Metabolism


Research Interest(s)

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Selected Publications

  • Kemp B, Howell N, Gildea J, Keller S, Padia S, Carey R. ATâ‚‚ receptor activation induces natriuresis and lowers blood pressure. Circulation research. 2014;115(3): 388-99. PMID: 24903104 | PMCID: PMC4116673
  • Taddeo E, Laker R, Breen D, Akhtar Y, Kenwood B, Liao J, Zhang M, Fazakerley D, Tomsig J, Harris T, Keller S, Chow J, Lynch K, Chokki M, Molkentin J, Turner N, James D, Yan Z, Hoehn K. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular metabolism. 2014;3(2): 124-34. PMID: 24634818 | PMCID: PMC3953683
  • Kemp B, Howell N, Gildea J, Keller S, Padia S. Intrarenal ghrelin receptors regulate ENaC-dependent sodium reabsorption by a cAMP-dependent pathway. Kidney international. 2013;84(3): 501-8. PMID: 23698230
  • Lansey M, Walker N, Hargett S, Stevens J, Keller S. Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis. American journal of physiology. Endocrinology and metabolism. 2012;303(10): E1273-86. PMID: 23011063 | PMCID: PMC3517634
  • Cutchins A, Harmon D, Kirby J, Doran A, Oldham S, Skaflen M, Klibanov A, Meller N, Keller S, Garmey J, McNamara C. Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion. Arteriosclerosis, thrombosis, and vascular biology. 2011;32(2): 317-24. PMID: 22075252 | PMCID: PMC3262109
  • Jordens I, Molle D, Xiong W, Keller S, McGraw T. Insulin-regulated aminopeptidase is a key regulator of GLUT4 trafficking by controlling the sorting of GLUT4 from endosomes to specialized insulin-regulated vesicles. Molecular biology of the cell. 2010;21(12): 2034-44. PMID: 20410133 | PMCID: PMC2883947
  • Kumar A, Lawrence J, Jung D, Ko H, Keller S, Kim J, Magnuson M, Harris T. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes. 2010;59(6): 1397-406. PMID: 20332342 | PMCID: PMC2874700
  • Chavez J, Roach W, Keller S, Lane W, Lienhard G. Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. The Journal of biological chemistry. 2008;283(14): 9187-95. PMID: 18258599 | PMCID: PMC2431020
  • Wallis M, Lankford M, Keller S. Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP. American journal of physiology. Endocrinology and metabolism. 2007;293(4): E1092-102. PMID: 17684103
  • The insulin-regulated aminopeptidase: a companion and regulator of GLUT4. Frontiers in bioscience : a journal and virtual library. 2003;8 s410-20. PMID: 12700100
  • Keller S, Davis A, Clairmont K. Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasis. The Journal of biological chemistry. 2002;277(20): 17677-86. PMID: 11884418
  • Fantin V, Wang Q, Lienhard G, Keller S. Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. American journal of physiology. Endocrinology and metabolism. 2000;278(1): E127-33. PMID: 10644546
  • Liu S, Wang Q, Lienhard G, Keller S. Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. The Journal of biological chemistry. 1999;274(25): 18093-9. PMID: 10364263
  • Keller S, Scott H, Mastick C, Aebersold R, Lienhard G. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. The Journal of biological chemistry. 1995;270(40): 23612-8. PMID: 7559527
  • Keller S, Lienhard G. Insulin signalling: the role of insulin receptor substrate 1. Trends in cell biology. 1994;4(4): 115-9. PMID: 14731733 sildenafil citrate viagra gold 800mg buy 25mg viagra onlinesale
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