Stuart S. Berr

Education

  • BA, Grinnell College, Grinnell, IA
  • PhD, Wake Forest University, Winston-Salem, NC, Oak Ridge National Laboratory, Oak Ridge, TN
  • Postdoc, University of Virginia
  • Postdoc, University of Virginia

Primary Appointment

  • Professor, Radiology and Biomedical Engineering
  • Professor, Radiology

Contact

Research Interest(s)

Developing magnetic resonance (MR) techniques as a tool for basic biomedical research.

Research Description

Our laboratory is involved with developing magnetic resonance (MR) techniques as a tool for basic biomedical research. We have developed noninvasive, non-contrast-enhanced methods for imaging blood perfusion, demonstrated to be effective in imaging blood flow to the kidneys, lungs, heart, and brain in humans. We were also the first to demonstrate the feasibility of imaging the lung using hydrogen-based MR methods.

We have also been developing micro-imaging techniques for the study of the heart and vascular system in mice and rats. This project has been particularly challenging due to the high spatial and temporal resolution requirements.

Selected Publications

  • Locke L, Mayo M, Yoo A, Williams M, Berr S. PET imaging of tumor associated macrophages using mannose coated 64Cu liposomes. Biomaterials. 2012;33(31): 7785-93. PMID: 22840225
  • West A, Anderson J, Epstein F, Meyer C, Hagspiel K, Berr S, Harthun N, Weltman A, Annex B, Kramer C. Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: a pilot study. Vascular medicine (London, England). 2012;17(1): 3-9. PMID: 22363013 | PMCID: PMC3306608
  • Xiao L, Zhang Y, Berr S, Chordia M, Pramoonjago P, Pu L, Pan D. A novel near-infrared fluorescence imaging probe for in vivo neutrophil tracking. Molecular imaging. 2012;11(5): 372-82. PMID: 22954181
  • Beyers R, Smith R, Xu Y, Piras B, Salerno M, Berr S, Meyer C, Kramer C, French B, Epstein F. Tâ‚‚ -weighted MRI of post-infarct myocardial edema in mice. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2011;67(1): 201-9. PMID: 21630350 | PMCID: PMC3188362
  • Jehle A, Xu Y, Dimaria J, French B, Epstein F, Berr S, Roy R, Kemp B, Carey R, Kramer C. A nonpeptide angiotensin II type 2 receptor agonist does not attenuate postmyocardial infarction left ventricular remodeling in mice. Journal of cardiovascular pharmacology. 2011;59(4): 363-8. PMID: 22157261 | PMCID: PMC3322306
  • Locke L, Williams M, Fairchild K, Zhong M, Kundu B, Berr S. FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice. International journal of molecular imaging. 2011;2011 356730. PMID: 22187641 | PMCID: PMC3236466
  • West A, Anderson J, Epstein F, Meyer C, Wang H, Hagspiel K, Berr S, Harthun N, Weltman A, Dimaria J, Hunter J, Christopher J, Kramer C. Low-density lipoprotein lowering does not improve calf muscle perfusion, energetics, or exercise performance in peripheral arterial disease. Journal of the American College of Cardiology. 2011;58(10): 1068-76. PMID: 21867844 | PMCID: PMC3182461
  • West A, Anderson J, Meyer C, Epstein F, Wang H, Hagspiel K, Berr S, Harthun N, DiMaria J, Hunter J, Christopher J, Chew J, Winberry G, Kramer C. The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline. Atherosclerosis. 2011;218(1): 156-62. PMID: 21570685 | PMCID: PMC3157540
  • Zhang Y, Xiao L, Chordia M, Locke L, Williams M, Berr S, Pan D. Neutrophil targeting heterobivalent SPECT imaging probe: cFLFLF-PEG-TKPPR-99mTc. Bioconjugate chemistry. 2010;21(10): 1788-93. PMID: 20843030
  • Locke L, Chordia M, Zhang Y, Kundu B, Kennedy D, Landseadel J, Xiao L, Fairchild K, Berr S, Linden J, Pan D. A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009;50(5): 790-7. PMID: 19372473 | PMCID: PMC3004780
  • Zhang Y, Kundu B, Fairchild K, Locke L, Berr S, Linden J, Pan D. Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging. Bioorganic & medicinal chemistry letters. 2007;17(24): 6876-8. PMID: 17959381 | PMCID: PMC2612577
  • Wu Y, McRoberts K, Berr S, Frierson H, Conaway M, Theodorescu D. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene. 2006;26(5): 765-73. PMID: 16878152