- Biomedical Sciences Graduate Program | Stephen S. Rich

Stephen S. Rich

Education

  • PhD, Purdue University

Primary Appointment

  • Professor, Public Health Sciences

Contact

Research Interest(s)

Genetic basis of common human disease, including type 1 diabetes, diabetic complications, ischemic stroke, atherosclerosis

Research Description

Dr. Rich's research is centered on understanding the genetic epidemiology of complex human disease, including the genes contributing to atherosclerosis, stroke and intermediate phenotypes (risk factors). These studies range from estimating the familial aggregation of disease and subclinical markers of disease within families, to gene mapping, gene discovery and functional significance of the gene variants. In the realm of atherosclerosis and risk factors, the primary study population is the Multi-Ethnic Study of Atherosclerosis (MESA), a collection of ~6,000 adults (aged 45+) without evidence of clinical disease. These subjects (Caucasian, African-American, Hispanic-American, Chinese-American) have extensive imaging, biomarker and clinical longitudinal data, as well as DNA for genetic studies. Currently, over 200 candidate genes related to atherosclerosis are being assessed, and both a genome-wide association scan (1 million SNPs) and linkage scan (6K SNPs in families) are being used to discover new genes and pathways. Examination of the genetic contribution to risk of ischemic stroke is the primary focus of the Siblings With Ischemic Stroke Study (SWISS) and the Ischemic Stroke Genetic Study (ISGS). Family-based linkage (SWISS), candidate gene (SWISS, ISGS) and genome-wide association (ISGS) methods have been utilized to detect stroke susceptibility genes. A primary goal of these research efforts is to identify novel genes and pathways that can serve a predictors of risk, identify those at highest risk of disease and, therefore, amenable to intervention, and to develop models of disease through manipulation of these genes and thus identify potential therapeutic targets.

Selected Publications

  • Schick U, Auer P, Bis J, Lin H, Wei P, Pankratz N, Lange L, Brody J, Stitziel N, Kim D, Carlson C, Fornage M, Haessler J, Hsu L, Jackson R, Kooperberg C, Leal S, Psaty B, Boerwinkle E, Tracy R, Ardissino D, Shah S, Willer C, Loos R, Melander O, Mcpherson R, Hovingh K, Reilly M, Watkins H, Girelli D, Fontanillas P, Chasman D, Gabriel S, Gibbs R, Nickerson D, Kathiresan S, Peters U, Dupuis J, Wilson J, Rich S, Morrison A, Benjamin E, Gross M, Reiner A. Association of exome sequences with plasma C-reactive protein levels in >9000 participants. Human molecular genetics. 2014. PMID: 25187575
  • Zanda M, Onengut-Gumuscu S, Walker N, Shtir C, Gallo D, Wallace C, Smyth D, Todd J, Hurles M, Plagnol V, Rich S. A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes. PLoS genetics. 2014;10(5): e1004367. PMID: 24875393 | PMCID: PMC4038470
  • Meschia J, Arnett D, Ay H, Brown R, Benavente O, Cole J, de Bakker P, Dichgans M, Doheny K, Fornage M, Grewal R, Gwinn K, Jern C, Conde J, Johnson J, Jood K, Laurie C, Lee J, Lindgren A, Markus H, McArdle P, McClure L, Mitchell B, Schmidt R, Rexrode K, Rich S, Rosand J, Rothwell P, Rundek T, Sacco R, Sharma P, Shuldiner A, Slowik A, Wassertheil-Smoller S, Sudlow C, Thijs V, Woo D, Worrall B, Wu O, Kittner S. Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes. Stroke; a journal of cerebral circulation. 2013;44(10): 2694-702. PMID: 24021684 | PMCID: PMC4056331
  • Manichaikul A, Naj A, Herrington D, Post W, Rich S, Rodriguez A. Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2012;32(8): 1991-9. PMID: 22628436
  • Manichaikul A, Chen W, Williams K, Wong Q, Sale M, Pankow J, Tsai M, Rotter J, Rich S, Mychaleckyj J. Analysis of family- and population-based samples in cohort genome-wide association studies. Human genetics. 2011;131(2): 275-87. PMID: 21805149 | PMCID: PMC3369696
  • Doran A, Lehtinen A, Meller N, Lipinski M, Slayton R, Oldham S, Skaflen M, Yeboah J, Rich S, Bowden D, McNamara C. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. Circulation research. 2010;106(7): 1303-11. PMID: 20185798 | PMCID: PMC2860382
  • Concannon P, Rich S, Nepom G. Genetics of type 1A diabetes. The New England journal of medicine. 2009;360(16): 1646-54. PMID: 19369670
  • Rich S, Akolkar B, Concannon P, Erlich H, Hilner J, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd J. Current status and the future for the genetics of type I diabetes. Genes and immunity. 2009;10 S128-31. PMID: 19956094 | PMCID: PMC2805458