Song Hu


  • PhD, Washington University in St. Louis
  • BS,MS, Tsinghua University

Primary Appointment

  • Assistant Professor, Biomedical Engineering


Research Interest(s)

Photoacoustic imaging, light microscopy, neuroscience, cardiovascular biology, cancer, regenerative medicine

Research Description

Our laboratory combines optics and ultrasound for in vivo high-resolution imaging of anatomical, functional, metabolic, and molecular contrasts at multiple spatial and temporal scales. Our research efforts encompass three main aspects: pushing the technical envelope to cover temporal scales that range from fast cellular dynamics to chronic disease progression, revealing novel optical/acoustic contrast mechanisms to enhance imaging sensitivity and specificity, and bridging the gaps between mechanistic studies in animals and clinical practice in humans.

Selected Publications

  • Cao R, Li J, Ning B, Sun N, Wang T, Zuo Z, Hu S. Functional and oxygen-metabolic photoacoustic microscopy of the awake mouse brain. NeuroImage. 2017;150 77-87. PMID: 28111187 | PMCID: PMC5391672
  • Cho Y, Zheng G, Augustine G, Hochbaum D, Cohen A, Knöpfel T, Pisanello F, Pavone F, Vellekoop I, Booth M, Hu S, Zhu J, Chen Z, Hoshi Y. Roadmap on neurophotonics. Journal of optics (2010). 2017;18(9). PMID: 28386392 | PMCID: PMC5378317
  • DeGeorge B, Ning B, Salopek L, Pineros-Fernandez A, Rodeheaver G, Peirce-Cottler S, Hu S, Cottler P, Campbell C. Advanced Imaging Techniques for Investigation of Acellular Dermal Matrix Biointegration. Plastic and reconstructive surgery. 2017;139(2): 395-405. PMID: 28121875
  • Kelly-Goss M, Ning B, Bruce A, Tavakol D, Yi D, Hu S, Yates P, Peirce S. Dynamic, heterogeneous endothelial Tie2 expression and capillary blood flow during microvascular remodeling. Scientific reports. 2017;7(1): 9049. PMID: 28831080 | PMCID: PMC5567377
  • Emerging concepts in functional and molecular photoacoustic imaging. Current opinion in chemical biology. 2016;33 25-31. PMID: 27111279 | PMCID: PMC5018467
  • Keller T, Butcher J, Broseghini-Filho G, Marziano C, DeLalio L, Rogers S, Ning B, Martin J, Chechova S, Cabot M, Shu X, Best A, Good M, Simão Padilha A, Purdy M, Yeager M, Peirce S, Hu S, Doctor A, Barrett E, Le T, Columbus L, Isakson B. Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX). Hypertension (Dallas, Tex. : 1979). 2016;68(6): 1494-1503. PMID: 27802421 | PMCID: PMC5159279
  • Song J, Wang F, Yang X, Ning B, Harp M, Culp S, Hu S, Huang P, Nie L, Chen J, Chen X. Gold Nanoparticle Coated Carbon Nanotube Ring with Enhanced Raman Scattering and Photothermal Conversion Property for Theranostic Applications. Journal of the American Chemical Society. 2016;138(22): 7005-15. PMID: 27193381 | PMCID: PMC5227596
  • Wang T, Sun N, Cao R, Ning B, Chen R, Zhou Q, Hu S. Multiparametric photoacoustic microscopy of the mouse brain with 300-kHz A-line rate. Neurophotonics. 2016;3(4): 045006. PMID: 27981062 | PMCID: PMC5129190
  • Yeh C, Liang J, Zhou Y, Hu S, Sohn R, Arbeit J, Wang L. Photoacoustic microscopy of arteriovenous shunts and blood diffusion in early-stage tumors. Journal of biomedical optics. 2016;21(2): 20501. PMID: 26882446 | PMCID: PMC4814546
  • Cao R, Kilroy J, Ning B, Wang T, Hossack J, Hu S. Multispectral photoacoustic microscopy based on an optical-acoustic objective. Photoacoustics. 2015;3(2): 55-9. PMID: 26236641 | PMCID: PMC4519805
  • Dixon A, Hu S, Klibanov A, Hossack J. Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles. Small (Weinheim an der Bergstrasse, Germany). 2015;11(25): 3066-77. PMID: 25703465 | PMCID: PMC4490110
  • Ning B, Sun N, Cao R, Chen R, Kirk Shung K, Hossack J, Lee J, Zhou Q, Hu S. Ultrasound-aided Multi-parametric Photoacoustic Microscopy of the Mouse Brain. Scientific reports. 2015;5 18775. PMID: 26688368 | PMCID: PMC4685318
  • Song K, Huang P, Yi C, Ning B, Hu S, Nie L, Chen X, Nie Z. Photoacoustic and Colorimetric Visualization of Latent Fingerprints. ACS nano. 2015;9(12): 12344-8. PMID: 26528550 | PMCID: PMC5223099
  • Yeh C, Soetikno B, Hu S, Maslov K, Wang L. Microvascular quantification based on contour-scanning photoacoustic microscopy. Journal of biomedical optics. 2014;19(9): 96011. PMID: 25223708 | PMCID: PMC4164706
  • Wang L, Hu S. Photoacoustic tomography: in vivo imaging from organelles to organs. Science (New York, N.Y.). 2012;335(6075): 1458-62. PMID: 22442475 | PMCID: PMC3322413