Scott O. Zeitlin

Education

  • BS, Stanford University
  • PhD, Columbia University
  • Postdoc, Columbia University

Primary Appointment

  • Associate Professor, Neuroscience

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau A, Yeung S, Humbert S, Saudou F, Klionsky D, Finkbeiner S, Zeitlin S, Marsh J, Housman D, Thompson L, Steffan J. Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(47): 16889-94. PMID: 25385587 | PMCID: PMC4250109
  • Fang C, Bolivar V, Gu J, Yang W, Zeitlin S, Ding X. Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model. Neuroscience. 2012;218 170-80. PMID: 22626646 | PMCID: PMC3393838
  • Zheng S, Clabough E, Sarkar S, Futter M, Rubinsztein D, Zeitlin S. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS genetics. 2010;6(2): e1000838. PMID: 20140187 | PMCID: PMC2816686
  • Thompson L, Aiken C, Kaltenbach L, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke J, Khashwji H, Lukacsovich T, Zhu Y, Lau A, Massey A, Hayden M, Zeitlin S, Finkbeiner S, Green K, LaFerla F, Bates G, Huang L, Patterson P, Lo D, Cuervo A, Marsh J, Steffan J. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. The Journal of cell biology. 2009;187(7): 1083-99. PMID: 20026656 | PMCID: PMC2806289
  • Hickey M, Kosmalska A, Enayati J, Cohen R, Zeitlin S, Levine M, Chesselet M. Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice. Neuroscience. 2008;157(1): 280-95. PMID: 18805465 | PMCID: PMC2665298
  • Clabough E, Zeitlin S. Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro. Human molecular genetics. 2006;15(4): 607-23. PMID: 16403806
  • Ryan A, Zeitlin S, Scrable H. Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis. Neurobiology of disease. 2006;24(2): 419-27. PMID: 16978870 | PMCID: PMC1803079