Roger Abounader

Education

  • MD, University of Heidelberg, Germany
  • PhD, University of Heidelberg, Germany
  • BS, American University of Beirut, Lebanon

Primary Appointment

  • Professor, Microbiology, Immunology, and Cancer Biology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, Purow B, Parsons S, Lawler S, Abounader R. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer research. 2014. PMID: 24425048 | PMCID: PMC3947487
  • Zhang Y, Kim J, Mueller A, Dey B, Yang Y, Lee D, Hachmann J, Finderle S, Park D, Christensen J, Schiff D, Purow B, Dutta A, Abounader R. Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. Cell death and differentiation. 2014;21(5): 720-34. PMID: 24440911 | PMCID: PMC3978301
  • Guessous F, Alvarado-Velez M, Marcinkiewicz L, Zhang Y, Kim J, Heister S, Kefas B, Godlewski J, Schiff D, Purow B, Abounader R. Oncogenic effects of miR-10b in glioblastoma stem cells. Journal of neuro-oncology. 2013;112(2): 153-63. PMID: 23307328 | PMCID: PMC3609924
  • Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, Mandell J, Abounader R. A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. Neoplasia (New York, N.Y.). 2013;15(8): 952-65. PMID: 23908595 | PMCID: PMC3730046
  • Kofman A, Kim J, Park S, Dupart E, Letson C, Bao Y, Ding K, Chen Q, Schiff D, Larner J, Abounader R. microRNA-34a promotes DNA damage and mitotic catastrophe. Cell cycle (Georgetown, Tex.). 2013;12(22): 3500-11. PMID: 24091633 | PMCID: PMC3906336
  • Zhang Y, Farenholtz K, Yang Y, Guessous F, Dipierro C, Calvert V, Deng J, Schiff D, Xin W, Lee J, Purow B, Christensen J, Petricoin E, Abounader R. Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013;19(6): 1433-44. PMID: 23386689 | PMCID: PMC3602223
  • Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, Kofman A, Schiff D, Christensen J, Abounader R. Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy. Molecular cancer therapeutics. 2011;11(2): 288-97. PMID: 22188814 | PMCID: PMC3277676
  • Guessous F, Zhang Y, Kofman A, Catania A, Li Y, Schiff D, Purow B, Abounader R. microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell cycle (Georgetown, Tex.). 2010;9(6): 1031-6. PMID: 20190569 | PMCID: PMC3278213
  • Li Y, Guessous F, DiPierro C, Zhang Y, Mudrick T, Fuller L, Johnson E, Marcinkiewicz L, Engelhardt M, Kefas B, Schiff D, Kim J, Abounader R. Interactions between PTEN and the c-Met pathway in glioblastoma and implications for therapy. Molecular cancer therapeutics. 2009;8(2): 376-85. PMID: 19190120
  • Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen T, Lopes B, Schiff D, Purow B, Abounader R. MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer research. 2009;69(19): 7569-76. PMID: 19773441 | PMCID: PMC2756313
  • Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, Fuller L, Johnson E, Lal B, Hussaini I, Bao Y, Laterra J, Schiff D, Abounader R. PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations. Cancer research. 2008;68(6): 1723-31. PMID: 18339852 | PMCID: PMC3813002