Robin A. Felder


  • PhD, Georgetown University

Primary Appointment

  • Professor, Pathology


Research Interest(s)

Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

Research Description

They have no symptoms, but subjects with untreated hypertension and salt sensitivity will have major health challenges such as blindness, stroke, kidney failure, and heart attacks. These devastating (and costly) endpoints will affect over 50% of the adult population. We have discovered a key regulatory pathway that controls sodium handling by epithelial cells, induces high blood pressure in mice, and is recapitulated in human test subjects. We have three laboratories (including support core facilities) focused on studying various aspects of the molecular basis of sodium excretion and blood pressure control. We employ genetic screening, cell based assays, clinical trial protocols, and behavioral surveys in order to fully understand the etiology of disease. Our automated drug discovery laboratory will also train students in modern techniques of setting up and running laboratory automation. In addition, we have a translational component of our research that has resulted in 8 "spin-out" companies, which have provided private sector opportunities for students post graduation.

Selected Publications

  • Han F, Konkalmatt P, Chen J, Gildea J, Felder R, Jose P, Armando I. MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells. Hypertension. 2015;65(5): 1118-25. PMID: 25801876 | PMCID: PMC4393363
  • Li F, Yang J, Jones J, Villar V, Yu P, Armando I, Felder R, Jose P. Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells. Endocrinology. 2015;156(6): 2211-21. PMID: 25825816 | PMCID: PMC4430625
  • Sanada H, Yoneda M, Yatabe J, Williams S, Bartlett J, White M, Gordon L, Felder R, Eisner G, Armando I, Jose P. Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade. The pharmacogenomics journal. 2015. PMID: 25732908
  • Automated specimen inspection, quality analysis, and its impact on patient safety: beyond the bar code. Clinical chemistry. 2014;60(3): 433-4. PMID: 24407911
  • Armando I, Konkalmatt P, Felder R, Jose P. The renal dopaminergic system: novel diagnostic and therapeutic approaches in hypertension and kidney disease. Translational research : the journal of laboratory and clinical medicine. 2014;165(4): 505-11. PMID: 25134060 | PMCID: PMC4305499
  • Felder R, Jackson K, Walter A. Process evaluation of an open architecture real-time molecular laboratory platform. Journal of laboratory automation. 2014;19(5): 468-73. PMID: 24811476
  • Gildea J, Seaton J, Victor K, Reyes C, Bigler Wang D, Pettigrew A, Courtner C, Shah N, Tran H, Van Sciver R, Carlson J, Felder R. Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. Clinical biochemistry. 2014;47(15): 89-94. PMID: 24976626
  • Gildea J, Shah I, Van Sciver R, Israel J, Enzensperger C, McGrath H, Jose P, Felder R. The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney international. 2014;86(1): 118-26. PMID: 24552847 | PMCID: PMC4077925
  • Jiang X, Konkalmatt P, Yang Y, Gildea J, Jones J, Cuevas S, Felder R, Jose P, Armando I. Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells. Hypertension. 2014;63(3): e74-80. PMID: 24379187 | PMCID: PMC3929206
  • Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder R, Mori H, Masaki T, Kobori H, Nishiyama A. Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. Journal of diabetes and its complications. 2014;28(5): 604-11. PMID: 24996978 | PMCID: PMC4153757
  • Sanada H, Yokokawa H, Yatabe J, Williams S, Felder R, Jose P, Takenosita S. Association between lifestyle-related disorders and visceral fat mass in Japanese males: a hospital based cross-sectional study. Environmental health and preventive medicine. 2014;19(6): 429-35. PMID: 25248615 | PMCID: PMC4235847
  • Yokokawa H, Goto A, Sanada H, Watanabe T, Felder R, Jose P, Yasumura S. Association between control to target blood pressures and healthy lifestyle factors among Japanese hypertensive patients: longitudinal data analysis from Fukushima Research of Hypertension (FRESH). Obesity research & clinical practice. 2014;8(4): e364-73. PMID: 25091358
  • Yu P, Han W, Villar V, Yang Y, Lu Q, Lee H, Li F, Quinn M, Gildea J, Felder R, Jose P. Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. Redox biology. 2014;2 570-9. PMID: 24688893 | PMCID: PMC3969603
  • Yu P, Sun M, Villar V, Zhang Y, Weinman E, Felder R, Jose P. Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells. Cellular signalling. 2014;26(11): 2521-9. PMID: 25049074 | PMCID: PMC4166567
  • Armando I, Villar V, Jones J, Lee H, Wang X, Asico L, Yu P, Yang J, Escano C, Pascua-Crusan A, Felder R, Jose P. Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013;28(3): 1422-34. PMID: 24308971 | PMCID: PMC3929671
  • Gildea J, Carlson J, Schoeffel C, Carey R, Felder R. Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure. Clinical biochemistry. 2013;46(12): 1131-4. PMID: 23726803 | PMCID: PMC3786136
  • Gildea J, Lahiff D, Van Sciver R, Weiss R, Shah N, McGrath H, Schoeffel C, Jose P, Carey R, Felder R. A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: the virtual renal biopsy. Clinica chimica acta; international journal of clinical chemistry. 2013;421 236-42. PMID: 23454474 | PMCID: PMC3724455
  • Gildea J, Tran H, Van Sciver R, Bigler Wang D, Carlson J, Felder R. A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells. Hypertension. 2013;61(5): 1021-7. PMID: 23509080 | PMCID: PMC3640476
  • Lee H, Abe Y, Lee I, Shrivastav S, Crusan A, Hüttemann M, Hopfer U, Felder R, Asico L, Armando I, Jose P, Kopp J. Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney international. 2013. PMID: 24132210 | PMCID: NIHMS521548
  • Carey R, Schoeffel C, Gildea J, Jones J, McGrath H, Gordon L, Park M, Sobota R, Underwood P, Williams J, Sun B, Raby B, Lasky-Su J, Hopkins P, Adler G, Williams S, Jose P, Felder R. Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension. 2012;60(5): 1359-66. PMID: 22987918 | PMCID: PMC3495588
  • Felder R, White M, Williams S, Jose P. Diagnostic tools for hypertension and salt sensitivity testing. Current opinion in nephrology and hypertension. 2012;22(1): 65-76. PMID: 23197156
  • Gildea J, McGrath H, Van Sciver R, Wang D, Felder R. Isolation, growth, and characterization of human renal epithelial cells using traditional and 3D methods. Methods in molecular biology (Clifton, N.J.). 2012;945 329-45. PMID: 23097116
  • Gildea J, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, Sasaki M, Yatabe J, Carey R, Jose P, Felder R. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension. 2012;60(2): 396-403. PMID: 22710646 | PMCID: PMC3406928
  • Gudmundsson H, Curran J, Kashef F, Snyder J, Smith S, Vargas-Pinto P, Bonilla I, Weiss R, Anderson M, Binkley P, Felder R, Carnes C, Band H, Hund T, Mohler P. Differential regulation of EHD3 in human and mammalian heart failure. Journal of molecular and cellular cardiology. 2012;52(5): 1183-90. PMID: 22406195 | PMCID: PMC3360944
  • Locke C, McEuen J, Felder R, Lesselroth B, Barrett T, Stevens B, Pope D. Evaluating an insulin infusion protocol in an acute care setting. Clinical nurse specialist CNS. 2012;25(5): 237-43. PMID: 22649844
  • Sanada H, Yokokawa H, Yoneda M, Yatabe J, Sasaki Yatabe M, Williams S, Felder R, Jose P. High body mass index is an important risk factor for the development of type 2 diabetes. Internal medicine (Tokyo, Japan). 2012;51(14): 1821-6. PMID: 22821094 | PMCID: PMC3540801
  • Villar V, Jones J, Armando I, Asico L, Escano C, Lee H, Wang X, Yang Y, Pascua-Crusan A, Palmes-Saloma C, Felder R, Jose P. Sorting nexin 1 loss results in d5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. The Journal of biological chemistry. 2012;288(1): 152-63. PMID: 23152498 | PMCID: PMC3537009
  • Wei S, Zhang Z, Yu Y, Weiss R, Felder R. Central actions of the chemokine stromal cell-derived factor 1 contribute to neurohumoral excitation in heart failure rats. Hypertension. 2012;59(5): 991-8. PMID: 22493069 | PMCID: PMC3366637
  • Yang Y, Zhang Y, Cuevas S, Villar V, Escano C, D Asico L, Yu P, Grandy D, Felder R, Armando I, Jose P. Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase. Free radical biology & medicine. 2012;53(3): 437-46. PMID: 22634053 | PMCID: PMC3408834
  • Yatabe J, Yatabe M, Yoneda M, Felder R, Jose P, Sanada H. Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. International journal of hypertension. 2012;2012 806810. PMID: 22518293 | PMCID: PMC3296214
  • Preanalytical errors introduced by sample-transportation systems: a means to assess them. Clinical chemistry. 2011;57(10): 1349-50. PMID: 21836080
  • Gildea J, Kemp B, Howell N, Van Sciver R, Carey R, Felder R. Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats. American journal of physiology. Renal physiology. 2011;300(4): F914-20. PMID: 21289050 | PMCID: PMC3074998
  • Yatabe J, Yoneda M, Yatabe M, Watanabe T, Felder R, Jose P, Sanada H. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology. 2011;152(4): 1582-8. PMID: 21303953
  • Yokokawa H, Goto A, Sanada H, Watanabe T, Felder R, Jose P, Yasumura S. Achievement status toward goal blood pressure levels and healthy lifestyles among Japanese hypertensive patients; cross-sectional survey results from Fukushima Research of Hypertension (FRESH). Internal medicine (Tokyo, Japan). 2011;50(11): 1149-56. PMID: 21628928
  • Yu P, Han W, Villar V, Li H, Arnaldo F, Concepcion G, Felder R, Quinn M, Jose P. Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk. Free radical biology & medicine. 2011;50(7): 832-40. PMID: 21193028 | PMCID: PMC3066436
  • Yu Y, Zhang Z, Wei S, Weiss R, Felder R. Peroxisome proliferator-activated receptor-γ regulates inflammation and renin-angiotensin system activity in the hypothalamic paraventricular nucleus and ameliorates peripheral manifestations of heart failure. Hypertension. 2011;59(2): 477-84. PMID: 22083161 | PMCID: PMC3266457
  • Zhang Z, Yu Y, Wei S, Felder R. Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent. American journal of physiology. Heart and circulatory physiology. 2011;302(3): H742-51. PMID: 22081704 | PMCID: PMC3353800
  • Zhang Z, Yu Y, Wei S, Nakamura Y, Nakamura K, Felder R. EP₃ receptors mediate PGE₂-induced hypothalamic paraventricular nucleus excitation and sympathetic activation. American journal of physiology. Heart and circulatory physiology. 2011;301(4): H1559-69. PMID: 21803943 | PMCID: PMC3197370