Richard J. Price


  • BS, Rochester Institute of Technology
  • PhD, University of Virginia
  • Postdoc, University of Virginia
  • MS, University of Virginia
  • PhD, University of Virginia
  • BS, Rochester Institute of Technology
  • MS, University of Virginia

Primary Appointment

  • Professor, Biomedical Engineering


Research Interest(s)

Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis

Research Description

The Price Laboratory in the Department of Biomedical Engineering at the University of Virginia has two major areas of research interest. The first centers on the use of image-guided focused ultrasound for targeted drug and gene delivery. Specific projects entail using MRI-guided focused ultrasound to deliver gene- and drug-bearing nanoparticles across the blood-brain barrier to both treat brain tumors and reverse neurodegeneration in Parkinson’s disease. In a similar vein, we are also actively investigating how the thermal and mechanical effects created by certain regimes of focused ultrasound can be used to elicit anti-tumor immune responses against breast cancer and melanoma. The second major area of research in the lab is vascular biomechanics. Here, our emphasis is on identifying the mechanisms through which epigenetic factors regulate collateral blood vessel growth and then using this information to develop new gene therapy approaches for treating peripheral arterial disease. Our research is highly collaborative. We work closely with UVa investigators in Radiology, the Human Immunotherapy Center, Neuro-oncology, and Cardiovascular Medicine, and we have a long-standing collaboration with investigators in the Johns Hopkins Center for Nanomedicine

Selected Publications

  • Gorick C, Sheybani N, Curley C, Price R. Listening in on the Microbubble Crowd: Advanced Acoustic Monitoring for Improved Control of Blood-Brain Barrier Opening with Focused Ultrasound. Theranostics. 2018;8(11): 2988-2991. PMID: 29897053 | PMCID: PMC5996352
  • Heuslein J, Gorick C, McDonnell S, Song J, Annex B, Price R. Exposure of Endothelium to Biomimetic Flow Waveforms Yields Identification of miR-199a-5p as a Potent Regulator of Arteriogenesis. Molecular therapy. Nucleic acids. 2018;12 829-844. PMID: 30153567 | PMCID: PMC6118158
  • Heuslein J, McDonnell S, Song J, Annex B, Price R. MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis. Frontiers in bioengineering and biotechnology. 2018;6 1. PMID: 29404323 | PMCID: PMC5786509
  • Curley C, Sheybani N, Bullock T, Price R. Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities. Theranostics. 2017;7(15): 3608-3623. PMID: 29109764 | PMCID: PMC5667336
  • Dallapiazza R, Timbie K, Holmberg S, Gatesman J, Lopes M, Price R, Miller G, Elias W. Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound. Journal of neurosurgery. 2017;128(3): 875-884. PMID: 28430035
  • Heuslein J, Gorick C, Song J, Price R. DNA Methyltransferase 1-Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point. Journal of the American Heart Association. 2017;6(12). PMID: 29191807 | PMCID: PMC5779061
  • Mead B, Kim N, Miller G, Hodges D, Mastorakos P, Klibanov A, Mandell J, Hirsh J, Suk J, Hanes J, Price R. Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model. Nano letters. 2017;17(6): 3533-3542. PMID: 28511006 | PMCID: PMC5539956
  • Timbie K, Afzal U, Date A, Zhang C, Song J, Wilson Miller G, Suk J, Hanes J, Price R. MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. Journal of controlled release : official journal of the Controlled Release Society. 2017;263 120-131. PMID: 28288892 | PMCID: PMC5593770
  • Heuslein J, Murrell K, Leiphart R, Llewellyn R, Meisner J, Price R. Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion. Scientific reports. 2016;6 27029. PMID: 27244251 | PMCID: PMC4886679
  • Mead B, Mastorakos P, Suk J, Klibanov A, Hanes J, Price R. Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound. Journal of controlled release : official journal of the Controlled Release Society. 2016;223 109-117. PMID: 26732553 | PMCID: PMC4739627
  • Heuslein J, Li X, Murrell K, Annex B, Peirce S, Price R. Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease. Microcirculation (New York, N.Y. : 1994). 2015;22(5): 360-9. PMID: 25866235 | PMCID: PMC4506703
  • Heuslein J, Meisner J, Li X, Song J, Vincentelli H, Leiphart R, Ames E, Blackman B, Blackman B, Price R. Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction. Arteriosclerosis, thrombosis, and vascular biology. 2015;35(11): 2354-65. PMID: 26338297 | PMCID: PMC4618717
  • Hsiang Y, Song J, Price R. The partitioning of nanoparticles to endothelium or interstitium during ultrasound-microbubble-targeted delivery depends on peak-negative pressure. Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology. 2015;17(8). PMID: 26594129 | PMCID: PMC4651175
  • Moyer L, Timbie K, Sheeran P, Price R, Miller G, Dayton P. High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. Journal of therapeutic ultrasound. 2015;3 7. PMID: 26045964 | PMCID: PMC4455327
  • Timbie K, Mead B, Price R. Drug and gene delivery across the blood-brain barrier with focused ultrasound. Journal of controlled release : official journal of the Controlled Release Society. 2015;219 61-75. PMID: 26362698 | PMCID: PMC4656107
  • Meisner J, Annex B, Price R. Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice. Journal of vascular surgery. 2014. PMID: 24582703 | PMCID: PMC4147032
  • Nance E, Timbie K, Miller G, Song J, Louttit C, Klibanov A, Shih T, Swaminathan G, Tamargo R, Woodworth G, Hanes J, Price R. Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. Journal of controlled release : official journal of the Controlled Release Society. 2014;189 123-32. PMID: 24979210 | PMCID: PMC4125545
  • Burke C, Alexander E, Timbie K, Kilbanov A, Price R. Ultrasound-activated agents comprised of 5FU-bearing nanoparticles bonded to microbubbles inhibit solid tumor growth and improve survival. Molecular therapy : the journal of the American Society of Gene Therapy. 2013;22(2): 321-8. PMID: 24172867 | PMCID: PMC3916048
  • Meisner J, Niu J, Sumer S, Price R. Trans-illuminated laser speckle imaging of collateral artery blood flow in ischemic mouse hindlimb. Journal of biomedical optics. 2013;18(9): 096011. PMID: 24045691 | PMCID: PMC3775679
  • Meisner J, Song J, Annex B, Price R. Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis. The American journal of pathology. 2013;183(6): 1710-8. PMID: 24095922 | PMCID: PMC5746951
  • Burke C, Suk J, Kim A, Hsiang Y, Klibanov A, Hanes J, Price R. Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles. Journal of controlled release : official journal of the Controlled Release Society. 2012;162(2): 414-21. PMID: 22800583 | PMCID: PMC3438364
  • Meisner J, Song J, Price R. Arteriolar and Venular Remodeling Are Differentially Regulated by Bone Marrow-Derived Cell-Specific CX3CR1 and CCR2 Expression. PloS one. 2012;7(9): e46312. PMID: 23029475 | PMCID: PMC3454326
  • Meisner J, Sumer S, Murrell K, Higgins T, Price R. Laser speckle flowmetry method for measuring spatial and temporal hemodynamic alterations throughout large microvascular networks. Microcirculation (New York, N.Y. : 1994). 2012;19(7): 619-31. PMID: 22591575 | PMCID: PMC3434303
  • Burke C, Hsiang Y, Alexander E, Kilbanov A, Price R. Covalently linking poly(lactic-co-glycolic acid) nanoparticles to microbubbles before intravenous injection improves their ultrasound-targeted delivery to skeletal muscle. Small (Weinheim an der Bergstrasse, Germany). 2011;7(9): 1227-35. PMID: 21456081 | PMCID: PMC3092637
  • Burke C, Klibanov A, Sheehan J, Price R. Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating. Journal of neurosurgery. 2011;114(6): 1654-61. PMID: 21214331
  • Burke C, Price R. Contrast ultrasound targeted treatment of gliomas in mice via drug-bearing nanoparticle delivery and microvascular ablation. Journal of visualized experiments : JoVE. 2011;. PMID: 21206463 | PMCID: PMC3159678
  • Meisner J, Price R. Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications. Microcirculation (New York, N.Y. : 1994). 2010;17(8): 583-99. PMID: 21044213 | PMCID: PMC2974339
  • Nickerson M, Song J, Meisner J, Bajikar S, Burke C, Shuptrine C, Owens G, Skalak T, Price R. Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(11): 1794-801. PMID: 19734197 | PMCID: PMC2766019
  • Anderson C, Hastings N, Blackman B, Price R. Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling. The American journal of pathology. 2008;173(4): 1220-8. PMID: 18772338 | PMCID: PMC2543088
  • Song J, Klibanov A, Hossack J, Price R. Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue. Investigative radiology. 2008;43(5): 322-9. PMID: 18424953 | PMCID: PMC2714264
  • Wieghaus K, Nickerson M, Petrie Aronin C, Sefcik L, Price R, Paige M, Brown M, Botchwey E. Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1). Biomaterials. 2008;29(35): 4698-708. PMID: 18804278 | PMCID: PMC2885000
  • Chappell J, Price R. Targeted therapeutic applications of acoustically active microspheres in the microcirculation. Microcirculation (New York, N.Y. : 1994). 2006;13(1): 57-70. PMID: 16393947
  • Wieghaus K, Capitosti S, Anderson C, Price R, Blackman B, Brown M, Botchwey E. Small molecule inducers of angiogenesis for tissue engineering. Tissue engineering. 2006;12(7): 1903-13. PMID: 16889520