R. Ariel Gomez

Primary Appointment

  • Professor, Pediatrics- Nephrology


Research Interest(s)

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Research Description

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Selected Publications

  • Belyea B, Xu F, Pentz E, Medrano S, Li M, Hu Y, Turner S, Legallo R, Jones C, Tario J, Liang P, Gross K, Sequeira-Lopez M, Gomez R. Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia. Nature communications. 2014;5 3273. PMID: 24549417 | PMCID: PMC3929784
  • Starke C, Betz H, Hickmann L, Lachmann P, Neubauer B, Kopp J, Sequeira-Lopez M, Gomez R, Hohenstein B, Todorov V, Hugo C. Renin Lineage Cells Repopulate the Glomerular Mesangium after Injury. Journal of the American Society of Nephrology : JASN. 2014. PMID: 24904091
  • Gomez R, Sequeira-Lopez M. Two oldies join forces to guard homeostasis. American journal of physiology. Renal physiology. 2013;305(11): F1546. PMID: 24049151
  • Pentz E, Cordaillat M, Carretero O, Tucker A, Sequeira Lopez M, Gomez R. Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype. American journal of physiology. Heart and circulatory physiology. 2012;302(12): H2545-52. PMID: 22523253 | PMCID: PMC3378259
  • Brunskill E, Sequeira-Lopez M, Pentz E, Lin E, Yu J, Aronow B, Potter S, Gomez R. Genes that confer the identity of the renin cell. Journal of the American Society of Nephrology : JASN. 2011;22(12): 2213-25. PMID: 22034642 | PMCID: PMC3279933
  • Castellanos Rivera R, Monteagudo M, Pentz E, Glenn S, Gross K, Carretero O, Sequeira-Lopez M, Gomez R. Transcriptional regulator RBP-J regulates the number and plasticity of renin cells. Physiological genomics. 2011;43(17): 1021-8. PMID: 21750232 | PMCID: PMC3180736
  • Kurt B, Kurtz L, Sequeira-Lopez M, Gomez R, Willecke K, Wagner C, Kurtz A. Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells. American journal of physiology. Renal physiology. 2011;300(3): F743-8. PMID: 21209011 | PMCID: PMC3064136
  • Medrano S, Monteagudo M, Sequeira-Lopez M, Pentz E, Gomez R. Two microRNAs, miR-330 and miR-125b-5p, mark the juxtaglomerular cell and balance its smooth muscle phenotype. American journal of physiology. Renal physiology. 2011;302(1): F29-37. PMID: 21993888 | PMCID: PMC3251334
  • Sequeira Lopez M, Gomez R. Development of the renal arterioles. Journal of the American Society of Nephrology : JASN. 2011;22(12): 2156-65. PMID: 22052047 | PMCID: PMC3250202
  • Chen L, Faulhaber-Walter R, Wen Y, Huang Y, Mizel D, Chen M, Sequeira Lopez M, Weinstein L, Gomez R, Briggs J, Schnermann J. Renal failure in mice with Gsalpha deletion in juxtaglomerular cells. American journal of nephrology. 2010;32(1): 83-94. PMID: 20551626 | PMCID: PMC2914394
  • Chen L, Kim S, Eisner C, Oppermann M, Huang Y, Mizel D, Li L, Chen M, Sequeira Lopez M, Weinstein L, Gomez R, Schnermann J, Briggs J. Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent. Journal of the American Society of Nephrology : JASN. 2010;21(6): 986-92. PMID: 20395378 | PMCID: PMC2900955
  • Desch M, Schreiber A, Schweda F, Madsen K, Friis U, Weatherford E, Sigmund C, Sequeira Lopez M, Gomez R, Todorov V. Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells. Hypertension. 2010;55(3): 660-6. PMID: 20065157 | PMCID: PMC2907524
  • Lopez M, Gomez R. The renin phenotype: roles and regulation in the kidney. Current opinion in nephrology and hypertension. 2010;19(4): 366-71. PMID: 20502328 | PMCID: PMC3079389
  • Sequeira Lopez M, Gomez R. Novel mechanisms for the control of renin synthesis and release. Current hypertension reports. 2010;12(1): 26-32. PMID: 20425155 | PMCID: PMC2861778
  • Sequeira-Lopez M, Weatherford E, Borges G, Monteagudo M, Pentz E, Harfe B, Carretero O, Sigmund C, Gomez R. The microRNA-processing enzyme dicer maintains juxtaglomerular cells. Journal of the American Society of Nephrology : JASN. 2010;21(3): 460-7. PMID: 20056748 | PMCID: PMC2831866
  • Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Lopez M, Gomez R, van Veen T, de Wit C, Kurtz A. Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension. Kidney international. 2010;78(8): 762-8. PMID: 20686449 | PMCID: PMC3033195
  • Xu D, Borges G, Davis D, Agassandian K, Sequeira Lopez M, Gomez R, Cassell M, Grobe J, Sigmund C. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiological genomics. 2010;43(6): 286-94. PMID: 21189370 | PMCID: PMC3068515