Paul N. Adler

Education

  • BS, Carnegie Mellon University, Pittsburgh, PA
  • MA, Boston University, Boston, MA
  • PhD, MIT, Cambridge, MA

Primary Appointment

  • Professor, Biology

Contact

Research Interest(s)

Planar signaling, polarity and morphogenesis.

Research Description

My major research interest is the genetic control of morphogenesis at the interface between the cell and tissue levels. As a model system we have studied planar polarity in the Drosophila wing, which is covered with an array of distally pointing hairs. We have found hair polarity is controlled via regulating the subcellular location for initiation of the growth of the hair. This site selection is under the control of the frizzled planar cell polarity pathway. It is thought that a key step in this process involves the accumulation of protein complexes along the proximal and distal sides of wing cells. A major focus of the laboratory is to understand how these asymmetric protein complexes specify the site for activation of the actin and microtubule cytoskeletons to elaborate the hair. Homologs of the frizzled pathway genes function to control gastrulation in the vertebrate embryo, polarity of the stereocillia in the inner ear and some have been implicated in oncogenesis. We are also studying how cells insure the integrity of cellular extensions such as hairs, bristles and dendrites. Once again we are using the Drosophila epidermis as a model. We have found that the tricornered and furry genes play a key role in this process and that these proteins accumulate in growing extensions. Our working model is that these proteins function in targeting intracellular transport to insure proper morphogenesis. Once again these genes are widely conserved and their homologs have been found to be important for cell polarity and shape in fungi, worms and flies. Related genes have been found to involved in cancer formation in mammals and tumorous outgrowths in flies.

Selected Publications

  • Nagaraj R, Adler P. Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development. Development (Cambridge, England). 2012;139(5): 906-16. PMID: 22278919 | PMCID: PMC3274354
  • Fang X, Adler P. Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes. Developmental biology. 2010;341(2): 360-74. PMID: 20211163 | PMCID: PMC2862085
  • Lu Q, Yan J, Adler P. The Drosophila planar polarity proteins inturned and multiple wing hairs interact physically and function together. Genetics. 2010;185(2): 549-58. PMID: 20351219 | PMCID: PMC2881136
  • Yan J, Lu Q, Fang X, Adler P. Rho1 has multiple functions in Drosophila wing planar polarity. Developmental biology. 2009;333(1): 186-99. PMID: 19576201 | PMCID: PMC2728161
  • Chung S, Kim S, Yoon J, Adler P, Yim J. The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. Genetics. 2007;176(2): 891-903. PMID: 17409077 | PMCID: PMC1894616
  • Ren N, Charlton J, Adler P. The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells. Genetics. 2007;176(4): 2223-34. PMID: 17565945 | PMCID: PMC1950627
  • Taylor J, Adler P. Cell rearrangement and cell division during the tissue level morphogenesis of evaginating Drosophila imaginal discs. Developmental biology. 2007;313(2): 739-51. PMID: 18082159 | PMCID: PMC2258245