Patrick A. Grant

Education

  • BS, University of Portsmouth, United Kingdom
  • PhD, Karolinska Institute, Stockholm, Sweden
  • Postdoc, HHMI, Pennsylvania State University, PA.

Primary Appointment

  • Associate Professor, Biochemistry and Molecular Genetics

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Lan X, Koutelou E, Schibler A, Chen Y, Grant P, Dent S. Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module. Molecular and cellular biology. 2015;35(10): 1777-87. PMID: 25755283 | PMCID: PMC4405643
  • Burke T, Miller J, Grant P. Direct inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7. The Journal of biological chemistry. 2013;288(47): 34266-75. PMID: 24129567 | PMCID: PMC3837167
  • McCullough S, Xu X, Dent S, Bekiranov S, Roeder R, Grant P. Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(52): 21319-24. PMID: 23236151 | PMCID: PMC3535616
  • Miller J, Grant P. The role of DNA methylation and histone modifications in transcriptional regulation in humans. Sub-cellular biochemistry. 2012;61 289-317. PMID: 23150256
  • Bian C, Xu C, Ruan J, Lee K, Burke T, Tempel W, Barsyte D, Li J, Wu M, Zhou B, Fleharty B, Paulson A, Allali-Hassani A, Zhou J, Mer G, Grant P, Workman J, Zang J, Min J. Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. The EMBO journal. 2011;30(14): 2829-42. PMID: 21685874 | PMCID: PMC3160252
  • Chen Y, Gatchel J, Lewis R, Mao C, Grant P, Zoghbi H, Dent S. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Human molecular genetics. 2011;21(2): 394-405. PMID: 22002997 | PMCID: PMC3276287
  • Gan Q, Thiébaud P, Thézé N, Jin L, Xu G, Grant P, Owens G. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. The Journal of biological chemistry. 2011;286(24): 21853-64. PMID: 21531708 | PMCID: PMC3122240
  • Lee K, Sardiu M, Swanson S, Gilmore J, Torok M, Grant P, Florens L, Workman J, Washburn M. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Molecular systems biology. 2011;7 503. PMID: 21734642 | PMCID: PMC3159981
  • Baker S, Phillips J, Anderson S, Qiu Q, Shabanowitz J, Smith M, Yates J, Hunt D, Grant P. Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae. Nature cell biology. 2010;12(3): 294-8. PMID: 20139971 | PMCID: PMC2856316
  • Ding S, Fischer W, Kaparakis-Liaskos M, Liechti G, Merrell D, Grant P, Ferrero R, Crowe S, Haas R, Hatakeyama M, Goldberg J. Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PloS one. 2010;5(4): e9875. PMID: 20368982 | PMCID: PMC2848570
  • McCullough S, Grant P. Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders. Advances in protein chemistry and structural biology. 2010;79 165-203. PMID: 20621284 | PMCID: PMC2964930
  • Stolzenberg D, Grant P, Bekiranov S. Epigenetic methodologies for behavioral scientists. Hormones and behavior. 2010;59(3): 407-16. PMID: 20955712 | PMCID: PMC3093106
  • Tsai H, Grant P, Rissman E. Sex differences in histone modifications in the neonatal mouse brain. Epigenetics : official journal of the DNA Methylation Society. 2008;4(1): 47-53. PMID: 19029819 | PMCID: PMC2667098
  • Baker S, Grant P. The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene. 2007;26(37): 5329-40. PMID: 17694076 | PMCID: PMC2746020
  • Daniel J, Grant P. Multi-tasking on chromatin with the SAGA coactivator complexes. Mutation research. 2007;618(1): 135-48. PMID: 17337012 | PMCID: PMC1892243