Patrice G. Guyenet

Education

  • BS, Ecole Normale Superieure
  • PhD, University of Paris
  • Postdoc, Yale University

Primary Appointment

  • Professor, Pharmacology

Contact

Research Interest(s)

Neural Control of Blood Pressure and Respiration

Research Description

My research is a branch of Integrative Neuroscience, a discipline that seeks to understand how the brain processes specific types of information. The laboratory studies how the mammalian brain regulates respiration and blood pressure, two physiological processes that are dysfunctional in very common diseases (hypertension, obesity, apneic syndromes, heart failure, etc.). The work consists of identifying relevant neuronal networks in rodents using electrophysiologic and neuroanatomic methods. The main focus is on a region of the brainstem that provides the chemical drive to breathe and contains the neurons that maintain blood pressure.

Selected Publications

  • Mulkey D, Rosin D, West G, Takakura A, Moreira T, Bayliss D, Guyenet P. Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(51): 14128-38. PMID: 18094252
  • Mulkey D, Talley E, Stornetta R, Siegel A, West G, Chen X, Sen N, Mistry A, Guyenet P, Bayliss D. TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(51): 14049-58. PMID: 18094244
  • The sympathetic control of blood pressure. Nature reviews. Neuroscience. 2006;7(5): 335-46. PMID: 16760914
  • Mulkey D, Mistry A, Guyenet P, Bayliss D. Purinergic P2 receptors modulate excitability but do not mediate pH sensitivity of RTN respiratory chemoreceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(27): 7230-3. PMID: 16822980
  • Stornetta R, Moreira T, Takakura A, Kang B, Chang D, West G, Brunet J, Mulkey D, Bayliss D, Guyenet P. Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(40): 10305-14. PMID: 17021186
  • Guyenet P, Mulkey D, Stornetta R, Bayliss D. Regulation of ventral surface chemoreceptors by the central respiratory pattern generator. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005;25(39): 8938-47. PMID: 16192384
  • Mulkey D, Stornetta R, Weston M, Simmons J, Parker A, Bayliss D, Guyenet P. Respiratory control by ventral surface chemoreceptor neurons in rats. Nature neuroscience. 2004;7(12): 1360-9. PMID: 15558061