Patrice G. Guyenet

Education

  • BS, Ecole Normale Superieure
  • PhD, University of Paris
  • Postdoc, Yale University

Primary Appointment

  • Professor, Pharmacology

Contact

Research Interest(s)

Neural control of blood pressure and respiration

Research Description

My research is a branch of Integrative Neuroscience, a discipline that seeks to understand how the brain processes specific types of information. The laboratory studies how the mammalian brain regulates respiration and blood pressure, two physiological processes that are dysfunctional in very common diseases (hypertension, obesity, apneic syndromes, heart failure, etc.). The work consists of identifying relevant neuronal networks in rodents using electrophysiologic and neuroanatomic methods. The main focus is on a region of the brainstem that provides the chemical drive to breathe and contains the neurons that maintain blood pressure.

Selected Publications

  • Bochorishvili G, Nguyen T, Coates M, Viar K, Stornetta R, Guyenet P. The orexinergic neurons receive synaptic input from C1 cells in rats. The Journal of comparative neurology. 2014;522(17): 3834-46. PMID: 24984694 | PMCID: PMC4167913
  • Abbott S, DePuy S, Nguyen T, Coates M, Stornetta R, Guyenet P. Selective optogenetic activation of rostral ventrolateral medullary catecholaminergic neurons produces cardiorespiratory stimulation in conscious mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013;33(7): 3164-77. PMID: 23407970 | PMCID: PMC3596815
  • Derecki N, Cronk J, Lu Z, Xu E, Abbott S, Guyenet P, Kipnis J. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature. 2012;484(7392): 105-9. PMID: 22425995 | PMCID: PMC3321067
  • Loss of brainstem serotonergic neurons impairs autoresuscitation in neonate rats: is this relevant to the sudden infant death syndrome? The Journal of physiology. 2011;589 5343-4. PMID: 22086249 | PMCID: PMC3240874
  • Guyenet P, Stornetta R, Bayliss D. Central respiratory chemoreception. The Journal of comparative neurology. 2010;518(19): 3883-906. PMID: 20737591 | PMCID: PMC2929977
  • Guyenet P, Bayliss D, Stornetta R, Fortuna M, Abbott S, DePuy S. Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity. Respiratory physiology & neurobiology. 2009;168(1): 59-68. PMID: 19712903 | PMCID: PMC2734912
  • Takakura A, Moreira T, Stornetta R, West G, Gwilt J, Guyenet P. Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats. The Journal of physiology. 2008;586 2975-91. PMID: 18440993 | PMCID: PMC2517201
  • Mulkey D, Rosin D, West G, Takakura A, Moreira T, Bayliss D, Guyenet P. Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(51): 14128-38. PMID: 18094252
  • Mulkey D, Talley E, Stornetta R, Siegel A, West G, Chen X, Sen N, Mistry A, Guyenet P, Bayliss D. TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(51): 14049-58. PMID: 18094244
  • The sympathetic control of blood pressure. Nature reviews. Neuroscience. 2006;7(5): 335-46. PMID: 16760914
  • Mulkey D, Mistry A, Guyenet P, Bayliss D. Purinergic P2 receptors modulate excitability but do not mediate pH sensitivity of RTN respiratory chemoreceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(27): 7230-3. PMID: 16822980
  • Stornetta R, Moreira T, Takakura A, Kang B, Chang D, West G, Brunet J, Mulkey D, Bayliss D, Guyenet P. Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006;26(40): 10305-14. PMID: 17021186
  • Guyenet P, Mulkey D, Stornetta R, Bayliss D. Regulation of ventral surface chemoreceptors by the central respiratory pattern generator. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005;25(39): 8938-47. PMID: 16192384
  • Mulkey D, Stornetta R, Weston M, Simmons J, Parker A, Bayliss D, Guyenet P. Respiratory control by ventral surface chemoreceptor neurons in rats. Nature neuroscience. 2004;7(12): 1360-9. PMID: 15558061