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Molecular and bioelectric devices; tissue regeneration.
Molecular and bioelectric devices: Control over surface and interfacial phenomena are a key to understanding and manipulating the properties of nanoscale materials and devices. Through electronic functionalization of device surfaces the research group aims to develop molecular and bioelectric devices with controlled interfacial geometry, electronic structure, charge and chemistry to engineer nanoscale paradigms for guided self-assembly, signal transduction, sensing, and modulation of magnetic moments or charge. These paradigms may be applied within implantable biomaterials, microfluidic biomolecular devices, and nanoelectronic devices for purposes of tissue regeneration and molecular or environmental sensing. Research techniques include the use of electrical and electrochemical methods for assembly, fabrication and characterization of the described nanoscale interfacial phenomena on electronic, biomedical and environmental systems of interest. Nathan Swami teaches courses in the area of semiconductor devices.
- Tissue Regeneration: The guided assembly of bio-degradable polymeric nanofibers scaffolds to mimic the extra-cellular matrix can result in assembly and regeneration of nerves, ligaments, and organs. My research group develops device interfaces for the control of electric fields during the electrospinning of the nanofibers to enable fiber alignment and patterning of fiber chemistry, which allows for hierarchical control of biofunctionality. Funding: NSF EFRI
- Bioelectric Devices: Our group develops microfluidic biomolecular devices with nanostructured edges, constrictions and gaps to locally enhance electric field gradients during dielectrophoresis. This is aimed to enhance kinetics of biological processes by selective preconcentration of biopolymers, cells, and growth factors of interests, as well as for localized initiation of various biological functions such as electroporation, electro-fusion and wound healing. Funding: NSF NER
- Molecular Device junctions: The control of surface charge and surfaces states are vital to signal transduction in the fields of nanoelectronics and photovoltaics. Towards this, my research group examines use of organic molecules to influence the modulation of charge at molecule-semiconductor interfaces, as well as for controlling the degree of electronic coupling at metal-molecule-semiconductor device junctions. Funding: NSF ECCS
- Environmental implications of Nanotechnology: The research group examines the risks and benefits to society from the use of silver nanotechnologies for antibacterial and wound healing applications. Specifically, we characterize silver ion release and the role of its catalytic effects, such as the influence of the resulting activated oxygen on biological processes of interest. (Funding: NSF NER)
- Zimmermann C, Burman D, Swami N, Krzyzanowska M, Leighl N, Moore M, Rodin G, Tannock I. Determinants of quality of life in patients with advanced cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2010;19(5): 621-9. PMID: 20349353
- Lo C, Burman D, Swami N, Gagliese L, Rodin G, Zimmermann C. Validation of the QUAL-EC for assessing quality of life in patients with advanced cancer. European journal of cancer (Oxford, England : 1990). 2010;47(4): 554-60. PMID: 21126869
- Bryson J, Coe G, Swami N, Murphy-Kane P, Seccareccia D, Le L, Rodin G, Zimmermann C. Administrative outcomes five years after opening an acute palliative care unit at a comprehensive cancer center. Journal of palliative medicine. 2010;13(5): 559-65. PMID: 20192842
- Wadhwa D, Burman D, Swami N, Rodin G, Lo C, Zimmermann C. Quality of life and mental health in caregivers of outpatients with advanced cancer. Psycho-oncology. 2011;22(2): 403-10. PMID: 22135229
- Neal R, Tholpady S, Foley P, Swami N, Ogle R, Botchwey E. Alignment and composition of laminin-polycaprolactone nanofiber blends enhance peripheral nerve regeneration. Journal of biomedical materials research. Part A. 2011. PMID: 22106069 | PMCID: PMC3550006
- Wentlandt K, Burman D, Swami N, Hales S, Rydall A, Rodin G, Lo C, Zimmermann C. Preparation for the end of life in patients with advanced cancer and association with communication with professional caregivers. Psycho-oncology. 2011. PMID: 21648015
- Jang R, Burman D, Swami N, Kotler J, Banerjee S, Ridley J, Mak E, Bryson J, Rodin G, Le L, Zimmermann C. Impact of an Oncology Palliative Care Clinic on Access to Home Care Services. The American journal of hospice & palliative care. 2012. PMID: 22777408
- Ezeala C, Ezeala M, Swami N. Strengthening the admissions process in health care professional education: focus on a premier Pacific Island medical college. Journal of educational evaluation for health professions. 2013;9 11. PMID: 23330054 | PMCID: PMC3545630