Michael G. Brown

Education

  • BS, Virginia Tech University
  • PhD, Medical College of Virginia, VCU, Richmond, VA

Primary Appointment

  • Professor, Medicine- Nephrology

Contact

Research Interest(s)

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Research Description

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Selected Publications

  • Wei H, Nash W, Makrigiannis A, Brown M. Impaired NK-cell education diminishes resistance to murine CMV infection. European journal of immunology. 2014. PMID: 25187217
  • Prince J, Lundgren A, Stadnisky M, Nash W, Beeber A, Turner S, Brown M. Multiparametric analysis of host response to murine cytomegalovirus in MHC class I-disparate mice reveals primacy of Dk-licensed Ly49G2+ NK cells in viral control. Journal of immunology (Baltimore, Md. : 1950). 2013;191(9): 4709-19. PMID: 24068668 | PMCID: PMC3820117
  • Lundgren A, Kim S, Stadnisky M, Brown M. Rapid discrimination of MHC class I and killer cell lectin-like receptor allele variants by high-resolution melt analysis. Immunogenetics. 2012;64(8): 633-40. PMID: 22752191 | PMCID: PMC3596047
  • Carroll V, Lundgren A, Wei H, Sainz S, Tung K, Brown M. Natural killer cells regulate murine cytomegalovirus-induced sialadenitis and salivary gland disease. Journal of virology. 2011;86(4): 2132-42. PMID: 22156514 | PMCID: PMC3302420
  • Stadnisky M, Xie X, Coats E, Bullock T, Brown M. Self MHC class I-licensed NK cells enhance adaptive CD8 T-cell viral immunity. Blood. 2011;117(19): 5133-41. PMID: 21436069 | PMCID: PMC3109538
  • Lassen M, Lukens J, Dolina J, Brown M, Hahn Y. Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state. Journal of immunology (Baltimore, Md. : 1950). 2010;184(5): 2693-701. PMID: 20124099 | PMCID: PMC2885840
  • Xie X, Stadnisky M, Coats E, Ahmed Rahim M, Lundgren A, Xu W, Makrigiannis A, Brown M. MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(19): 8754-9. PMID: 20421478 | PMCID: PMC2889336
  • Rodriguez M, Lundgren A, Sabastian P, Li Q, Churchill G, Brown M. A Cmv2 QTL on chromosome X affects MCMV resistance in New Zealand male mice. Mammalian genome : official journal of the International Mammalian Genome Society. 2009;20(7): 414-23. PMID: 19641964 | PMCID: PMC2767104
  • Stadnisky M, Manichaikul A, Lundgren A, Brown M. NK gene complex and chromosome 19 loci enhance MHC resistance to murine cytomegalovirus infection. Immunogenetics. 2009;61(11): 755-64. PMID: 19820922 | PMCID: PMC2880465
  • Xie X, Stadnisky M, Brown M. MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus. Journal of immunology (Baltimore, Md. : 1950). 2009;182(11): 7163-71. PMID: 19454713 | PMCID: PMC2730597
  • Brown M, Scalzo A. NK gene complex dynamics and selection for NK cell receptors. Seminars in immunology. 2008;20(6): 361-8. PMID: 18640056 | PMCID: PMC2646111
  • Li L, Huang L, Sung S, Lobo P, Brown M, Gregg R, Engelhard V, Okusa M. NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. Journal of immunology (Baltimore, Md. : 1950). 2007;178(9): 5899-911. PMID: 17442974
  • Xie X, Dighe A, Clark P, Sabastian P, Buss S, Brown M. Deficient major histocompatibility complex-linked innate murine cytomegalovirus immunity in MA/My.L-H2b mice and viral downregulation of H-2k class I proteins. Journal of virology. 2006;81(1): 229-36. PMID: 17050600 | PMCID: PMC1797260