Mazhar Adli

Education

  • PhD, University of North Carolina at Chapel Hill
  • MSc, Sabanci University

Contact

Research Interest(s)

The role of chromatin regulatory networks in stem cell differentiation, development and disease

Research Description

Our lab seek to develop new technologies and utilize existing genomic and epigenomic tools to understand the role chromatin regulatory networks in normal and malignant development.

Selected Publications

  • Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders L, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert B, Chiosis G, Nimer S, Bernstein B, Verstovsek S, Levine R. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012. PMID: 22820254
  • Adli M, Bernstein B. Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nature protocols. 2011;6(10): 1656-68. PMID: 21959244
  • Chapman M, Lawrence M, Keats J, Cibulskis K, Sougnez C, Schinzel A, Harview C, Brunet J, Ahmann G, Adli M, Anderson K, Ardlie K, Auclair D, Baker A, Bergsagel P, Bernstein B, Drier Y, Fonseca R, Gabriel S, Hofmeister C, Jagannath S, Jakubowiak A, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins L, Onofrio R, Pugh T, Rajkumar S, Ramos A, Siegel D, Sivachenko A, Stewart A, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn W, Garraway L, Meyerson M, Lander E, Getz G, Golub T. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011;471(7339): 467-72. PMID: 21430775 | PMCID: NIHMS385546
  • Koche R, Smith Z, Adli M, Gu H, Ku M, Gnirke A, Bernstein B, Meissner A. Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell stem cell. 2011;8(1): 96-105. PMID: 21211784 | PMCID: PMC3220622
  • Adli M, Merkhofer E, Cogswell P, Baldwin A. IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PloS one. 2010;5(2): e9428. PMID: 20195534 | PMCID: PMC2828475
  • Adli M, Zhu J, Bernstein B. Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors. Nature methods. 2010;7(8): 615-8. PMID: 20622861 | PMCID: PMC2924612
  • Goren A, Ozsolak F, Shoresh N, Ku M, Adli M, Hart C, Gymrek M, Zuk O, Regev A, Milos P, Bernstein B. Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nature methods. 2009;7(1): 47-9. PMID: 19946276 | PMCID: PMC2862482
  • Ku M, Koche R, Rheinbay E, Mendenhall E, Endoh M, Mikkelsen T, Presser A, Nusbaum C, Xie X, Chi A, Adli M, Kasif S, Ptaszek L, Cowan C, Lander E, Koseki H, Bernstein B. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS genetics. 2008;4(10): e1000242. PMID: 18974828 | PMCID: PMC2567431
  • Dan H, Adli M, Baldwin A. Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer research. 2007;67(13): 6263-9. PMID: 17616684
  • Adli M, Baldwin A. IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation. The Journal of biological chemistry. 2006;281(37): 26976-84. PMID: 16840782
  • Kutuk O, Adli M, Poli G, Basaga H. Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts. BioFactors (Oxford, England). 2004;20(1): 1-10. PMID: 15096656