Mazhar Adli

Education

  • PhD, University of North Carolina at Chapel Hill
  • MSc, Sabanci University
  • Postdoc, Harvard Medical School, Mass general Hosptal, Broad Institute of Harvad and MIT

Contact

Research Interest(s)

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Research Description

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viagra rezeptfrei deutschland link Our lab is focused on the role chromatin organization in genome regulation during normal and malignant development such as cancer. We aim to identify epigenetic mechanisms and epigenomic features that will help us better understand the dynamic chromatin structure, function and nuclear organization during cellular differentiation programs such as stem cell self renewal and differentiation. In the lab, we apply state-of-the-art genomic and epigenomic tools and seek to develop additional technologies to answer the following specific questions.

  • How are chromatin and cellular states established during normal development?
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    Selected Publications

    • Kuscu C, Arslan S, Singh R, Thorpe J, Adli M. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Nature biotechnology. 2014;32(7): 677-83. PMID: 24837660
    • Rissman E, Adli M. Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds. Endocrinology. 2014;155(8): 2770-80. PMID: 24885575 | PMCID: PMC4098001
    • Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders L, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert B, Chiosis G, Nimer S, Bernstein B, Verstovsek S, Levine R. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012. PMID: 22820254 | PMCID: 22820254
    • Adli M, Bernstein B. Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nature protocols. 2011;6(10): 1656-68. PMID: 21959244 | PMCID: 21959244
    • Chapman M, Lawrence M, Keats J, Cibulskis K, Sougnez C, Schinzel A, Harview C, Brunet J, Ahmann G, Adli M, Anderson K, Ardlie K, Auclair D, Baker A, Bergsagel P, Bernstein B, Drier Y, Fonseca R, Gabriel S, Hofmeister C, Jagannath S, Jakubowiak A, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins L, Onofrio R, Pugh T, Rajkumar S, Ramos A, Siegel D, Sivachenko A, Stewart A, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn W, Garraway L, Meyerson M, Lander E, Getz G, Golub T. Initial genome sequencing and analysis of multiple myeloma. Nature. 2011;471(7339): 467-72. PMID: 21430775 | PMCID: NIHMS385546
    • Adli M, Merkhofer E, Cogswell P, Baldwin A. IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PloS one. 2010;5(2): e9428. PMID: 20195534 | PMCID: PMC2828475
    • Adli M, Zhu J, Bernstein B. Genome-wide chromatin maps derived from limited numbers of hematopoietic progenitors. Nature methods. 2010;7(8): 615-8. PMID: 20622861 | PMCID: PMC2924612
    • Goren A, Ozsolak F, Shoresh N, Ku M, Adli M, Hart C, Gymrek M, Zuk O, Regev A, Milos P, Bernstein B. Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA. Nature methods. 2009;7(1): 47-9. PMID: 19946276 | PMCID: PMC2862482
    • Ku M, Koche R, Rheinbay E, Mendenhall E, Endoh M, Mikkelsen T, Presser A, Nusbaum C, Xie X, Chi A, Adli M, Kasif S, Ptaszek L, Cowan C, Lander E, Koseki H, Bernstein B. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS genetics. 2008;4(10): e1000242. PMID: 18974828 | PMCID: PMC2567431
    • Dan H, Adli M, Baldwin A. Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer research. 2007;67(13): 6263-9. PMID: 17616684 | PMCID: 17616684
    • Adli M, Baldwin A. IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation. The Journal of biological chemistry. 2006;281(37): 26976-84. PMID: 16840782 | PMCID: 16840782