Mani S. Mahadevan

Education

  • BS, University of Ottawa
  • MD, University of Ottawa
  • Intern, University of Western Ontario
  • Residency, University of Ottawa

Primary Appointment

  • Professor, Pathology

Contact

Research Interest(s)

taking more than 100 mg viagra

Research Description

http://archsimply.pl/?v=viagra-pill-cutter viagra pill cutter

Selected Publications

  • Gladman J, Yadava R, Mandal M, Yu Q, Kim Y, Mahadevan M. NKX2-5, a modifier of skeletal muscle pathology due to RNA toxicity. Human molecular genetics. 2014. PMID: 25168381
  • Gladman J, Mandal M, Srinivasan V, Mahadevan M. Age of onset of RNA toxicity influences phenotypic severity: evidence from an inducible mouse model of myotonic dystrophy (DM1). PloS one. 2013;8(9): e72907. PMID: 24039817 | PMCID: PMC3764231
  • Myotonic dystrophy: is a narrow focus obscuring the rest of the field? Current opinion in neurology. 2012;25(5): 609-13. PMID: 22892953
  • Genetics. Exposing a DUX tale. Science (New York, N.Y.). 2010;329(5999): 1607-8. PMID: 20929834
  • Mastroyiannopoulos N, Chrysanthou E, Kyriakides T, Uney J, Mahadevan M, Phylactou L. The effect of myotonic dystrophy transcript levels and location on muscle differentiation. Biochemical and biophysical research communications. 2008;377(2): 526-31. PMID: 18930030
  • Yadava R, Frenzel-McCardell C, Yu Q, Srinivasan V, Tucker A, Puymirat J, Thornton C, Prall O, Harvey R, Mahadevan M. RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. Nat Genet. 2008;40(1): 61-8. PMCID: PMC2909759
  • Yadava R, Frenzel-McCardell C, Yu Q, Srinivasan V, Tucker A, Puymirat J, Thornton C, Prall O, Harvey R, Mahadevan M. RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. Nature genetics. 2007;40(1): 61-8. PMID: 18084293 | PMCID: PMC2909759
  • Mahadevan M, Yadava R, Yu Q, Balijepalli S, Frenzel-McCardell C, Bourne T, Phillips L. Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy. Nature genetics. 2006;38(9): 1066-70. PMID: 16878132 | PMCID: PMC2909745
  • Mastroyiannopoulos N, Feldman M, Uney J, Mahadevan M, Phylactou L. Woodchuck post-transcriptional element induces nuclear export of myotonic dystrophy 3' untranslated region transcripts. EMBO reports. 2005;6(5): 458-63. PMID: 15832171 | PMCID: PMC1299300
  • Amack J, Reagan S, Mahadevan M. Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD. The Journal of cell biology. 2002;159(3): 419-29. PMID: 12427866 | PMCID: PMC2173077
  • Amack J, Mahadevan M. The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation. Human molecular genetics. 2001;10(18): 1879-87. PMID: 11555624
  • Tiscornia G, Mahadevan M. Myotonic dystrophy: the role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios. Molecular cell. 2000;5(6): 959-67. PMID: 10911990
  • Amack J, Paguio A, Mahadevan M. Cis and trans effects of the myotonic dystrophy (DM) mutation in a cell culture model. Human molecular genetics. 1999;8(11): 1975-84. PMID: 10484765
  • Mahadevan M, Amemiya C, Jansen G, Sabourin L, Baird S, Neville C, Wormskamp N, Segers B, Batzer M, Lamerdin J. Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene. Human molecular genetics. 1993;2(3): 299-304. PMID: 8499920
  • Sabouri L, Mahadevan M, Narang M, Lee D, Surh L, Korneluk R. Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene. Nature genetics. 1993;4(3): 233-8. PMID: 8358430
  • Foff E, Mahadevan M. Therapeutics development in myotonic dystrophy type 1. Muscle Nerve. 44(2): 160-9. PMCID: PMC3136655
  • Mahadevan M, Yadava R, Yu Q, Balijepalli S, Frenzel-McCardell C, Bourne T, Phillips L. Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy. Nat Genet. 38(9): 1066-70. PMCID: PMC2909745
http://vipohity.com/?ed=viagra-ajanta viagra ajanta
viagra medicine for men