M. Mitchell Smith


  • BA, Johns Hopkins University, Baltimore MD
  • Postdoc, Johns Hopkins University, Baltimore MD
  • Postdoc, Edinburgh University, Edinburgh, Scotland, UK
  • PhD, Johns Hopkins University, Baltimore MD

Primary Appointment

  • Professor, Microbiology, Immunology, and Cancer Biology


Research Interest(s)

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Research Description

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best generic viagra reviews The roles of the histone amino-terminal tail domains in chromatin structure and function, particularly in DNA replication and the maintenance of genome integrity. The roles of the nucleosome in regulating gene transcription, and how histone-histone interactions function in shaping the chromatin template. The roles of the histones in determining the structure and morphogenesis of the centromere of the chromosome. The roles of the "SNF/SWI" complex in remodeling chromatin for transcription, and its interaction with the adenovirus E1A oncoprotein.

Selected Publications

  • Kim J, Hsu J, Smith M, Allis C. Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(15): 5779-84. PMID: 22451923 | PMCID: PMC3326485
  • Talbert P, Ahmad K, Almouzni G, Ausió J, Berger F, Bhalla P, Bonner W, Cande W, Chadwick B, Chan S, Cross G, Cui L, Dimitrov S, Doenecke D, Eirin-López J, Gorovsky M, Hake S, Hamkalo B, Holec S, Jacobsen S, Kamieniarz K, Khochbin S, Ladurner A, Landsman D, Latham J, Loppin B, Malik H, Marzluff W, Pehrson J, Postberg J, Schneider R, Singh M, Smith M, Thompson E, Torres-Padilla M, Tremethick D, Turner B, Waterborg J, Wollmann H, Yelagandula R, Zhu B, Henikoff S. A unified phylogeny-based nomenclature for histone variants. Epigenetics & chromatin. 2012;5 7. PMID: 22650316 | PMCID: PMC3380720
  • Hang M, Smith M. Genetic analysis implicates the Set3/Hos2 histone deacetylase in the deposition and remodeling of nucleosomes containing H2A.Z. Genetics. 2011;187(4): 1053-66. PMID: 21288874 | PMCID: PMC3070515
  • Jensen K, Santisteban M, Urekar C, Smith M. Histone H2A.Z acid patch residues required for deposition and function. Molecular genetics and genomics : MGG. 2011;285(4): 287-96. PMID: 21359583 | PMCID: PMC3253533
  • Santisteban M, Hang M, Smith M. Histone variant H2A.Z and RNA polymerase II transcription elongation. Molecular and cellular biology. 2011;31(9): 1848-60. PMID: 21357739 | PMCID: PMC3133230
  • Baker S, Phillips J, Anderson S, Qiu Q, Shabanowitz J, Smith M, Yates J, Hunt D, Grant P. Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae. Nature cell biology. 2010;12(3): 294-8. PMID: 20139971 | PMCID: PMC2856316
  • French S, Sikes M, Hontz R, Osheim Y, Lambert T, El Hage A, Smith M, Tollervey D, Smith J, Beyer A. Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes. Molecular and cellular biology. 2010;31(3): 482-94. PMID: 21098118 | PMCID: PMC3028620
  • Iizuka M, Takahashi Y, Mizzen C, Cook R, Fujita M, Allis C, Frierson H, Fukusato T, Smith M. Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. Gene. 2009;436(1): 108-14. PMID: 19393168 | PMCID: PMC2674512