Loren D. Erickson

Education

  • BS, Seattle Pacific University
  • PhD, The University of Iowa
  • Postdoc, Dartmouth Medical School

Primary Appointment

  • Associate Professor, Microbiology, Immunology, and Cancer Biology

Contact

Research Interest(s)

Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders

Research Description

CURRENT PROJECTS • Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production • Defining the mechanisms by which autoimmune susceptibility elicits inflammation and recruitment of innate immune cells in secondary lymphoid organs that affect B cell function • Examining helper activity and inflammatory cytokines of human T cells in peripheral blood of SLE patients that affect B cell function • Characterizing the regulation and activity in primary mouse T follicular helper cells and T follicular regulatory cells to control B cell responses • Defining the signal transduction events through the BCMA cytokine receptor that regulates both T follicular helper cell homeostasis and plasma cell survival in autoimmunity • Characterizing the development and persistence of IgE antibodies to airway allergens Go to Loren Erickson's Lab Site for detailed information about his lab and his research.

Selected Publications

  • Coquery C, Loo W, Wade N, Bederman A, Tung K, Lewis J, Hess H, Erickson L. BAFF regulates T follicular helper cells and affects accumulation and IFNγ production in autoimmunity. Arthritis & rheumatology (Hoboken, N.J.). 2014. PMID: 25385309
  • Coquery C, Wade N, Loo W, Kinchen J, Cox K, Jiang C, Tung K, Erickson L. Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice. PloS one. 2014;9(7): e102284. PMID: 25010693 | PMCID: PMC4092127
  • Peperzak V, Vikström I, Walker J, Glaser S, LePage M, Coquery C, Erickson L, Fairfax K, Mackay F, Strasser A, Nutt S, Tarlinton D. Mcl-1 is essential for the survival of plasma cells. Nature immunology. 2013;14(3): 290-7. PMID: 23377201 | PMCID: PMC4041127
  • Coquery C, Erickson L. Regulatory roles of the tumor necrosis factor receptor BCMA. Critical reviews in immunology. 2012;32(4): 287-305. PMID: 23237506 | PMCID: PMC3548317
  • Coquery C, Loo W, Buszko M, Lannigan J, Erickson L. Optimized protocol for the isolation of spleen-resident murine neutrophils. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012;81(9): 806-14. PMID: 22760952 | PMCID: PMC3548322
  • Ernst P, Erickson L, Loo W, Scott K, Wiznerowicz E, Brown C, Torres-Velez F, Alam M, Black S, McDuffie M, Feldman S, Wallace J, McKnight G, Padol I, Hunt R, Tung K. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. American journal of physiology. Gastrointestinal and liver physiology. 2011;302(1): G105-15. PMID: 21921286 | PMCID: PMC3345967
  • Jiang C, Loo W, Greenley E, Tung K, Erickson L. B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus. Journal of immunology (Baltimore, Md. : 1950). 2011;186(11): 6136-47. PMID: 21536804 | PMCID: PMC3181142
  • Panchanathan R, Liu H, Liu H, Fang C, Erickson L, Pitha P, Choubey D. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. Journal of immunology (Baltimore, Md. : 1950). 2011;188(1): 270-8. PMID: 22116829 | PMCID: PMC3244553
  • Panchanathan R, Shen H, Duan X, Rathinam V, Erickson L, Fitzgerald K, Choubey D. Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein. Journal of immunology (Baltimore, Md. : 1950). 2011;186(12): 6762-70. PMID: 21551362 | PMCID: PMC3110550
  • Wolf A, Mozdzanowska K, Quinn W, Metzgar M, Williams K, Caton A, Meffre E, Bram R, Erickson L, Allman D, Cancro M, Erikson J. Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI. The Journal of clinical investigation. 2011;121(10): 3954-64. PMID: 21881204 | PMCID: PMC3195469
  • Panchanathan R, Duan X, Shen H, Rathinam V, Erickson L, Fitzgerald K, Choubey D. Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. Journal of immunology (Baltimore, Md. : 1950). 2010;185(12): 7385-93. PMID: 21057088 | PMCID: PMC3059233
  • Jørgensen T, Alfaro J, Enriquez H, Jiang C, Loo W, Atencio S, Bupp M, Mailloux C, Metzger T, Flannery S, Rozzo S, Kotzin B, Rosemblatt M, Bono M, Erickson L. Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus. Journal of immunology (Baltimore, Md. : 1950). 2009;184(2): 775-86. PMID: 20018631 | PMCID: PMC2841050
  • Khuda S, Loo W, Janz S, Van Ness B, Erickson L. Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors. Journal of immunology (Baltimore, Md. : 1950). 2008;181(11): 7537-49. PMID: 19017943 | PMCID: PMC2841033
  • Benson M, Erickson L, Gleeson M, Noelle R. Affinity of antigen encounter and other early B-cell signals determine B-cell fate. Current opinion in immunology. 2007;19(3): 275-80. PMID: 17433651 | PMCID: PMC2827202
  • O'Connor B, Vogel L, Zhang W, Loo W, Shnider D, Lind E, Ratliff M, Noelle R, Erickson L. Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor. Journal of immunology (Baltimore, Md. : 1950). 2006;177(11): 7723-32. PMID: 17114443 | PMCID: PMC2819292
  • Noelle R, Erickson L. Determinations of B cell fate in immunity and autoimmunity. Current directions in autoimmunity. 2004;8 1-24. PMID: 15564715
  • O'Connor B, Raman V, Erickson L, Cook W, Weaver L, Ahonen C, Lin L, Mantchev G, Bram R, Noelle R. BCMA is essential for the survival of long-lived bone marrow plasma cells. The Journal of experimental medicine. 2004;199(1): 91-8. PMID: 14707116 | PMCID: PMC1887725
  • Erickson L, Lin L, Duan B, Morel L, Noelle R. A genetic lesion that arrests plasma cell homing to the bone marrow. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(22): 12905-10. PMID: 14555759 | PMCID: PMC240717
  • O'Connor B, Gleeson M, Noelle R, Erickson L. The rise and fall of long-lived humoral immunity: terminal differentiation of plasma cells in health and disease. Immunological reviews. 2003;194 61-76. PMID: 12846808 | PMCID: PMC2827865
  • Ahonen C, Manning E, Erickson L, O'Connor B, Lind E, Pullen S, Kehry M, Noelle R. The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nature immunology. 2002;3(5): 451-6. PMID: 11967542 | PMCID: PMC2834483
  • Erickson L, Durell B, Vogel L, O'Connor B, Cascalho M, Yasui T, Kikutani H, Noelle R. Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. The Journal of clinical investigation. 2002;109(5): 613-20. PMID: 11877469 | PMCID: PMC150892
  • Erickson L, Foy T, Waldschmidt T. Murine B1 B cells require IL-5 for optimal T cell-dependent activation. Journal of immunology (Baltimore, Md. : 1950). 2001;166(3): 1531-9. PMID: 11160193 | PMCID: PMC2832833
  • Erickson L, Vogel L, Cascalho M, Wong J, Wabl M, Durell B, Noelle R. B cell immunopoiesis: visualizing the impact of CD40 engagement on the course of T cell-independent immune responses in an Ig transgenic system. European journal of immunology. 2000;30(11): 3121-31. PMID: 11093126 | PMCID: PMC2827196
  • Erickson L, Tygrett L, Bhatia S, Grabstein K, Waldschmidt T. Differential expression of CD22 (Lyb8) on murine B cells. International immunology. 1996;8(7): 1121-9. PMID: 8757957 | PMCID: PMC2859887