Loren D. Erickson

Education

  • BA, Seattle Pacific University
  • PhD, The University of Iowa
  • Postdoc, Dartmouth Medical School

Primary Appointment

  • Associate Professor, Microbiology, Immunology, and Cancer Biology

Contact

Research Interest(s)

Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus and multiple myeloma; Immunotherapeutics in the treatment of B cell disorders

Research Description

        INTRODUCTION: B lymphocytes constitute a major cellular component of the immune system, whose function is to produce secreted proteins called antibodies that protect the host against pathogens. A hallmark of this antibody-based protection is the capacity of specialized B cells, plasma cells (PC), to have a prolonged lifespan and is the raison d'être for vaccines to establish long-term immunity. In healthy individuals, the persistence of PCs is an asset for protective humoral immunity but is a significant liability in PC disorders. Thus, understanding the factors that determine PC development and survival takes on considerable importance in terms of both biology and therapeutics. Our laboratory studies two PC disorders: first, is the PC malignancy, multiple myeloma (MM) and second, is the antibody-mediated autoimmune disease, systemic lupus erythematosus.
Go to Loren Erickson’s Lab Site for detailed information about his lab and his research.

Selected Publications

  • Coquery C, Loo W, Buszko M, Lannigan J, Erickson L. Optimized protocol for the isolation of spleen-resident murine neutrophils. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012;81(9): 806-14. PMID: 22760952
  • Ernst P, Erickson L, Loo W, Scott K, Wiznerowicz E, Brown C, Torres-Velez F, Alam M, Black S, McDuffie M, Feldman S, Wallace J, McKnight G, Padol I, Hunt R, Tung K. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. American journal of physiology. Gastrointestinal and liver physiology. 2011;302(1): G105-15. PMID: 21921286 | PMCID: PMC3345967
  • Jiang C, Loo W, Greenley E, Tung K, Erickson L. B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus. Journal of immunology (Baltimore, Md. : 1950). 2011;186(11): 6136-47. PMID: 21536804 | PMCID: PMC3181142
  • Jørgensen T, Alfaro J, Enriquez H, Jiang C, Loo W, Atencio S, Bupp M, Mailloux C, Metzger T, Flannery S, Rozzo S, Kotzin B, Rosemblatt M, Bono M, Erickson L. Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus. Journal of immunology (Baltimore, Md. : 1950). 2009;184(2): 775-86. PMID: 20018631 | PMCID: PMC2841050
  • Khuda S, Loo W, Janz S, Van Ness B, Erickson L. Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors. Journal of immunology (Baltimore, Md. : 1950). 2008;181(11): 7537-49. PMID: 19017943 | PMCID: PMC2841033
  • Benson M, Erickson L, Gleeson M, Noelle R. Affinity of antigen encounter and other early B-cell signals determine B-cell fate. Current opinion in immunology. 2007;19(3): 275-80. PMID: 17433651 | PMCID: PMC2827202