Laura Jansen

Education

  • MD/PhD, Saint Louis University
  • Medical Residency, Washington University

Contact

Research Interest(s)

Pediatric Epilepsy, Human Brain Development, Inhibitory Neurotransmission

Research Description

My research interests are related to conditions that cause epilepsy and brain malformations in children. My lab uses a combination of biochemical, electrophysiological, and imaging techniques to analyze both human brain specimens and cell culture models. Current projects ongoing in the lab include: 1) Characterizing the development of GABAergic inhibition in the premature and neonatal brain, and determining the effect of conditions causing seizures on this development. 2) Identifying the consequences of abnormal PI3K/AKT pathway activity on neuronal signaling. 3) Determining the histopathologic and functional outcomes of genetic mutations that cause neurologic disease in children.

Selected Publications

  • Cheah C, Westenbroek R, Roden W, Kalume F, Oakley J, Jansen L, Catterall W. Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome. Channels (Austin, Tex.). 2013;7(6). PMID: 23965409
  • Jansen L, Hevner R, Roden W, Hahn S, Jung S, Gospe Jr S. Glial localization of antiquitin: Implications for pyridoxine-dependent epilepsy. Annals of neurology. 2013. PMID: 24122892
  • Poliachik S, Poliakov A, Jansen L, McDaniel S, Wray C, Kuratani J, Saneto R, Ojemann J, Novotny E. Tissue localization during resective epilepsy surgery. Neurosurgical focus. 2013;34(6): E8. PMID: 23724842
  • Hyslop A, Droker B, Jansen L. Clinical reasoning: an unexpected diagnosis in a 4-month-old infant with lethargy and H1N1 influenza. Neurology. 2011;76(18): e88-92. PMID: 21536632
  • Donsante A, Johnson P, Jansen L, Kaler S. Somatic mosaicism in Menkes disease suggests choroid plexus-mediated copper transport to the developing brain. American journal of medical genetics. Part A. 2010;152(10): 2529-34. PMID: 20799318
  • Jansen L, Peugh L, Roden W, Ojemann J. Impaired maturation of cortical GABA(A) receptor expression in pediatric epilepsy. Epilepsia. 2010;51(8): 1456-67. PMID: 20132297
  • Roden W, Peugh L, Jansen L. Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex. Neuroscience letters. 2010;483(3): 167-72. PMID: 20692323
  • Jansen L, Peugh L, Ojemann J. GABA(A) receptor properties in catastrophic infantile epilepsy. Epilepsy research. 2008;81(2): 188-97. PMID: 18650066
  • Zeng L, Ouyang Y, Gazit V, Cirrito J, Jansen L, Ess K, Yamada K, Wozniak D, Holtzman D, Gutmann D, Wong M. Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiology of disease. 2007;28(2): 184-96. PMID: 17714952
  • Gurnett C, Dobbs M, Keppel C, Pincus E, Jansen L, Bowcock A. Additional evidence of a locus for complex febrile and afebrile seizures on chromosome 12q22-23.3. Neurogenetics. 2006;8(1): 61-3. PMID: 16972079
  • Jansen L, Uhlmann E, Crino P, Gutmann D, Wong M. Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia. 2006;46(12): 1871-80. PMID: 16393152
  • Wong M, Ess K, Uhlmann E, Jansen L, Li W, Crino P, Mennerick S, Yamada K, Gutmann D. Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model. Annals of neurology. 2003;54(2): 251-6. PMID: 12891680