Kyle L. Hoehn

Education

  • PhD, Colorado State University

Primary Appointment

  • Assistant Professor, Pharmacology

Contact

Research Interest(s)

Research Description

My laboratory investigates the mechanisms whereby alterations in cellular metabolism contribute to the pathophysiology of complex metabolic diseases including diabetes, obesity, and cancer. Three ongoing research areas in my lab include the regulation of fatty acid metabolism in the liver via protein acetylation, the role of glucose transporter 6 in endometrial cancer, and small molecule drug discovery for modulators of mitochondrial metabolism for the treatment of obesity and cancer.

Selected Publications

  • Bajwa A, Rosin D, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey G, Stevens B, Jobin K, Kenwood B, Hoehn K, Lynch K, Okusa M. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. Journal of the American Society of Nephrology : JASN. 2014. PMID: 25145931
  • Byrne F, Poon I, Modesitt S, Tomsig J, Chow J, Healy M, Baker W, Atkins K, Lancaster J, Marchion D, Moley K, Ravichandran K, Slack-Davis J, Hoehn K. Metabolic Vulnerabilities in Endometrial Cancer. Cancer research. 2014. PMID: 25205105
  • Healy M, Chow J, Byrne F, Breen D, Leitinger N, Li C, Lackner C, Caldwell S, Hoehn K. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. Journal of hepatology. 2014. PMID: 25450719
  • Kenwood B, Weaver J, Bajwa A, Poon I, Byrne F, Murrow B, Calderone J, Huang L, Divakaruni A, Tomsig J, Okabe K, Lo R, Cameron Coleman G, Columbus L, Yan Z, Saucerman J, Smith J, Holmes J, Lynch K, Ravichandran K, Uchiyama S, Santos W, Rogers G, Okusa M, Bayliss D, Hoehn K. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Molecular metabolism. 2014;3(2): 114-23. PMID: 24634817 | PMCID: PMC3953706
  • Laker R, Lillard T, Okutsu M, Zhang M, Hoehn K, Connelly J, Yan Z. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes. 2014;63(5): 1605-11. PMID: 24430439
  • Laker R, Xu P, Ryall K, Sujkowski A, Kenwood B, Chain K, Zhang M, Royal M, Hoehn K, Driscoll M, Adler P, Wessells R, Saucerman J, Yan Z. A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo. The Journal of biological chemistry. 2014;289(17): 12005-15. PMID: 24644293 | PMCID: PMC4002107
  • Lee J, Walsh M, Hoehn K, James D, Wherry E, Choi Y. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. Journal of immunology (Baltimore, Md. : 1950). 2014;192(7): 3190-9. PMID: 24567531 | PMCID: PMC3965631
  • Taddeo E, Laker R, Breen D, Akhtar Y, Kenwood B, Liao J, Zhang M, Fazakerley D, Tomsig J, Harris T, Keller S, Chow J, Lynch K, Chokki M, Molkentin J, Turner N, James D, Yan Z, Hoehn K. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular metabolism. 2014;3(2): 124-34. PMID: 24634818 | PMCID: PMC3953683
  • Lira V, Okutsu M, Zhang M, Greene N, Laker R, Breen D, Hoehn K, Yan Z. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013;27(10): 4184-93. PMID: 23825228 | PMCID: PMC4046188
  • Caldwell S, Hoehn K, Hahn Y. The strange and critical intersection of hepatitis c and lipoprotein metabolism: 'C-zing' the oil. Hepatology (Baltimore, Md.). 2012. PMID: 23055122
  • Franko A, von Kleist-Retzow J, Böse M, Sanchez-Lasheras C, Brodesser S, Krut O, Kunz W, Wiedermann D, Hoehn M, Stöhr O, Moll L, Freude S, Krone W, Schubert M, Wiesner R. Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle. Journal of molecular medicine (Berlin, Germany). 2012;90(10): 1145-60. PMID: 22411022
  • Hoehn K, Turner N, Cooney G, James D. Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice. The Journal of biological chemistry. 2012;287(19): 15801; author reply 15802. PMID: 22563100 | PMCID: PMC3346128
  • Modesitt S, Hsu J, Chowbina S, Lawrence R, Hoehn K. Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2012;22(5): 732-41. PMID: 22635025
  • Patel S, Hoehn K, Lawrence R, Sawbridge L, Talbot N, Tomsig J, Turner N, Cooney G, Whitehead J, Kraegen E, Cleasby M. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. Endocrinology. 2012;153(11): 5231-46. PMID: 22989629 | PMCID: PMC3498583
  • Park D, Han C, Elliott M, Kinchen J, Trampont P, Das S, Collins S, Lysiak J, Hoehn K, Ravichandran K. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature. 2011;477(7363): 220-4. PMID: 21857682 | PMCID: PMC3513690
  • Hoehn K, Turner N, Swarbrick M, Wilks D, Preston E, Phua Y, Joshi H, Furler S, Larance M, Hegarty B, Leslie S, Pickford R, Hoy A, Kraegen E, James D, Cooney G. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell metabolism. 2010;11(1): 70-6. PMID: 20074529 | PMCID: PMC2824926
  • Larance M, Rowland A, Hoehn K, Humphreys D, Preiss T, Guilhaus M, James D. Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Molecular & cellular proteomics : MCP. 2010;9(4): 682-94. PMID: 20051463 | PMCID: PMC2860230
  • Murrow B, Hoehn K. Mitochondrial regulation of insulin action. The international journal of biochemistry & cell biology. 2010;42(12): 1936-9. PMID: 20837159
  • Crowe S, Wu L, Economou C, Turpin S, Matzaris M, Hoehn K, Hevener A, James D, Duh E, Watt M. Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell metabolism. 2009;10(1): 40-7. PMID: 19583952
  • Hoehn K, Salmon A, Hohnen-Behrens C, Turner N, Hoy A, Maghzal G, Stocker R, Van Remmen H, Kraegen E, Cooney G, Richardson A, James D. Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(42): 17787-92. PMID: 19805130 | PMCID: PMC2764908
  • Richards A, Colgrave M, Zhang J, Webster J, Simpson F, Preston E, Wilks D, Hoehn K, Stephenson M, Macdonald G, Prins J, Cooney G, Xu A, Whitehead J. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. Molecular endocrinology (Baltimore, Md.). 2009;24(1): 229-39. PMID: 19855092
  • Hoehn K, Hohnen-Behrens C, Cederberg A, Wu L, Turner N, Yuasa T, Ebina Y, James D. IRS1-independent defects define major nodes of insulin resistance. Cell metabolism. 2008;7(5): 421-33. PMID: 18460333 | PMCID: PMC2443409
  • Yip M, Ramm G, Larance M, Hoehn K, Wagner M, Guilhaus M, James D. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes. Cell metabolism. 2008;8(5): 384-98. PMID: 19046570
  • Holland W, Brozinick J, Wang L, Hawkins E, Sargent K, Liu Y, Narra K, Hoehn K, Knotts T, Siesky A, Nelson D, Karathanasis S, Fontenot G, Birnbaum M, Summers S. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell metabolism. 2007;5(3): 167-79. PMID: 17339025
  • Holland W, Knotts T, Chavez J, Wang L, Hoehn K, Summers S. Lipid mediators of insulin resistance. Nutrition reviews. 2007;65(6): S39-46. PMID: 17605313
  • Turner N, Bruce C, Beale S, Hoehn K, So T, Rolph M, Cooney G. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes. 2007;56(8): 2085-92. PMID: 17519422
  • Stratford S, Hoehn K, Liu F, Summers S. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. The Journal of biological chemistry. 2004;279(35): 36608-15. PMID: 15220355
  • Hoehn K, Hudachek S, Summers S, Florant G. Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators. American journal of physiology. Regulatory, integrative and comparative physiology. 2003;286(3): R498-504. PMID: 14656767
  • Hoehn K, Summers S. Assaying AKT/protein kinase B activity. Methods in molecular medicine. 2003;83 137-44. PMID: 12619725