Kyle L. Hoehn

Education

  • PhD, Colorado State University

Primary Appointment

  • Assistant Professor, Pharmacology

Contact

Research Interest(s)

Research Description

My laboratory investigates the mechanisms whereby alterations in cellular metabolism contribute to the pathophysiology of complex metabolic diseases including diabetes, obesity, and cancer. Three ongoing research areas in my lab include the regulation of fatty acid metabolism in the liver via protein acetylation, the role of glucose transporter 6 in endometrial cancer, and small molecule drug discovery for modulators of mitochondrial metabolism for the treatment of obesity and cancer.

Selected Publications

  • Bajwa A., Rosin D. L., Chroscicki P., Lee S., Dondeti K., Ye H., Kinsey G. R., Stevens B. K., Jobin K., Kenwood B. M., Hoehn K. L., Lynch K. R., Okusa M. D.. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury J Am Soc Nephrol. .
  • Bajwa A., Rosin D. L., Chroscicki P., Lee S., Dondeti K., Ye H., Kinsey G. R., Stevens B. K., Jobin K., Kenwood B. M., Hoehn K. L., Lynch K. R., Okusa M. D.. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury J Am Soc Nephrol. .
  • Byrne F. L., Poon I. K., Modesitt S. C., Tomsig J. L., Chow J. D., Healy M. E., Baker W. D., Atkins K. A., Lancaster J. M., Marchion D. C., Moley K. H., Ravichandran K. S., Slack-Davis J. K., Hoehn K. L.. Metabolic Vulnerabilities in Endometrial Cancer Cancer Res. .
  • Byrne F. L., Poon I. K., Modesitt S. C., Tomsig J. L., Chow J. D., Healy M. E., Baker W. D., Atkins K. A., Lancaster J. M., Marchion D. C., Moley K. H., Ravichandran K. S., Slack-Davis J. K., Hoehn K. L.. Metabolic Vulnerabilities in Endometrial Cancer Cancer Res. .
  • Caldwell S., Hoehn K. L., Hahn Y. S.. The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil Hepatology. 57(5): 1684-7.
  • Caldwell S., Hoehn K. L., Hahn Y. S.. The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil Hepatology. 57(5): 1684-7.
  • Chow J. D., Lawrence R. T., Healy M. E., Dominy J. E., Liao J. A., Byrne F. L., Breen D. S., Okutsu S., Kenwood B. M., Mas V., Lackner C., Caldwell S. H., Tomsig J. L., Cooney G. J., Turner N., Puigserver P. B., James D. E., Villén J., Hoehn K. L.. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation Molecular Metabolism. .
  • Chow J. D., Lawrence R. T., Healy M. E., Dominy J. E., Liao J. A., Byrne F. L., Breen D. S., Okutsu S., Kenwood B. M., Mas V., Lackner C., Caldwell S. H., Tomsig J. L., Cooney G. J., Turner N., Puigserver P. B., James D. E., Villén J., Hoehn K. L.. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation Molecular Metabolism. .
  • Crowe S., Wu L. E., Economou C., Turpin S. M., Matzaris M., Hoehn K. L., Hevener A. L., James D. E., Duh E. J., Watt M. J.. Pigment epithelium-derived factor contributes to insulin resistance in obesity Cell Metab. 10(1): 40-7.
  • Crowe S., Wu L. E., Economou C., Turpin S. M., Matzaris M., Hoehn K. L., Hevener A. L., James D. E., Duh E. J., Watt M. J.. Pigment epithelium-derived factor contributes to insulin resistance in obesity Cell Metab. 10(1): 40-7.
  • Franko A., von Kleist-Retzow J. C., Bose M., Sanchez-Lasheras C., Brodesser S., Krut O., Kunz W. S., Wiedermann D., Hoehn M., Stohr O., Moll L., Freude S., Krone W., Schubert M., Wiesner R. J.. Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle J Mol Med (Berl). 90(10): 1145-60.
  • Franko A., von Kleist-Retzow J. C., Bose M., Sanchez-Lasheras C., Brodesser S., Krut O., Kunz W. S., Wiedermann D., Hoehn M., Stohr O., Moll L., Freude S., Krone W., Schubert M., Wiesner R. J.. Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle J Mol Med (Berl). 90(10): 1145-60.
  • Healy M.E., Chow J.D.Y., Byrne F.L., Breen D.S., Leitinger N., Li C., Lackner C., Caldwell S.H., Hoehn K.L.. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine Journal of Hepatology. .
  • Healy M.E., Chow J.D.Y., Byrne F.L., Breen D.S., Leitinger N., Li C., Lackner C., Caldwell S.H., Hoehn K.L.. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine Journal of Hepatology. .
  • Hoehn K. L., Hohnen-Behrens C., Cederberg A., Wu L. E., Turner N., Yuasa T., Ebina Y., James D. E.. IRS1-independent defects define major nodes of insulin resistance Cell Metab. 7(5): 421-33.
  • Hoehn K. L., Hohnen-Behrens C., Cederberg A., Wu L. E., Turner N., Yuasa T., Ebina Y., James D. E.. IRS1-independent defects define major nodes of insulin resistance Cell Metab. 7(5): 421-33.
  • Hoehn K. L., Hudachek S. F., Summers S. A., Florant G. L.. Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators Am J Physiol Regul Integr Comp Physiol. 286(3): R498-504.
  • Hoehn K. L., Hudachek S. F., Summers S. A., Florant G. L.. Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators Am J Physiol Regul Integr Comp Physiol. 286(3): R498-504.
  • Hoehn K. L., Salmon A. B., Hohnen-Behrens C., Turner N., Hoy A. J., Maghzal G. J., Stocker R., Van Remmen H., Kraegen E. W., Cooney G. J., Richardson A. R., James D. E.. Insulin resistance is a cellular antioxidant defense mechanism Proc Natl Acad Sci U S A. 106(42): 17787-92.
  • Hoehn K. L., Salmon A. B., Hohnen-Behrens C., Turner N., Hoy A. J., Maghzal G. J., Stocker R., Van Remmen H., Kraegen E. W., Cooney G. J., Richardson A. R., James D. E.. Insulin resistance is a cellular antioxidant defense mechanism Proc Natl Acad Sci U S A. 106(42): 17787-92.
  • Hoehn K. L., Summers S. A.. Assaying AKT/protein kinase B activity Methods Mol Med. 83 137-44.
  • Hoehn K. L., Summers S. A.. Assaying AKT/protein kinase B activity Methods Mol Med. 83 137-44.
  • Hoehn K. L., Turner N., Cooney G. J., James D. E.. Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice J Biol Chem. 287(19): 15801; author reply 15802.
  • Hoehn K. L., Turner N., Cooney G. J., James D. E.. Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice J Biol Chem. 287(19): 15801; author reply 15802.
  • Hoehn K. L., Turner N., Swarbrick M. M., Wilks D., Preston E., Phua Y., Joshi H., Furler S. M., Larance M., Hegarty B. D., Leslie S. J., Pickford R., Hoy A. J., Kraegen E. W., James D. E., Cooney G. J.. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity Cell Metab. 11(1): 70-6.
  • Hoehn K. L., Turner N., Swarbrick M. M., Wilks D., Preston E., Phua Y., Joshi H., Furler S. M., Larance M., Hegarty B. D., Leslie S. J., Pickford R., Hoy A. J., Kraegen E. W., James D. E., Cooney G. J.. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity Cell Metab. 11(1): 70-6.
  • Holland W. L., Brozinick J. T., Wang L. P., Hawkins E. D., Sargent K. M., Liu Y., Narra K., Hoehn K. L., Knotts T. A., Siesky A., Nelson D. H., Karathanasis S. K., Fontenot G. K., Birnbaum M. J., Summers S. A.. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance Cell Metab. 5(3): 167-79.
  • Holland W. L., Brozinick J. T., Wang L. P., Hawkins E. D., Sargent K. M., Liu Y., Narra K., Hoehn K. L., Knotts T. A., Siesky A., Nelson D. H., Karathanasis S. K., Fontenot G. K., Birnbaum M. J., Summers S. A.. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance Cell Metab. 5(3): 167-79.
  • Holland W. L., Knotts T. A., Chavez J. A., Wang L. P., Hoehn K. L., Summers S. A.. Lipid mediators of insulin resistance Nutr Rev. 65(6): S39-46.
  • Holland W. L., Knotts T. A., Chavez J. A., Wang L. P., Hoehn K. L., Summers S. A.. Lipid mediators of insulin resistance Nutr Rev. 65(6): S39-46.
  • Kenwood B. M., Weaver J. L., Bajwa A., Poon I. K., Byrne F. L., Murrow B. A., Calderone J. A., Huang L., Divakaruni A. S., Tomsig J. L., Okabe K., Lo R. H., Cameron Coleman G., Columbus L., Yan Z., Saucerman J. J., Smith J. S., Holmes J. W., Lynch K. R., Ravichandran K. S., Uchiyama S., Santos W. L., Rogers G. W., Okusa M. D., Bayliss D. A., Hoehn K. L.. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane Mol Metab. 3(2): 114-23.
  • Kenwood B. M., Weaver J. L., Bajwa A., Poon I. K., Byrne F. L., Murrow B. A., Calderone J. A., Huang L., Divakaruni A. S., Tomsig J. L., Okabe K., Lo R. H., Cameron Coleman G., Columbus L., Yan Z., Saucerman J. J., Smith J. S., Holmes J. W., Lynch K. R., Ravichandran K. S., Uchiyama S., Santos W. L., Rogers G. W., Okusa M. D., Bayliss D. A., Hoehn K. L.. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane Mol Metab. 3(2): 114-23.
  • Laker R. C., Lillard T. S., Okutsu M., Zhang M., Hoehn K. L., Connelly J. J., Yan Z.. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1alpha gene and age-dependent metabolic dysfunction in the offspring Diabetes. 63(5): 1605-11.
  • Laker R. C., Lillard T. S., Okutsu M., Zhang M., Hoehn K. L., Connelly J. J., Yan Z.. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1alpha gene and age-dependent metabolic dysfunction in the offspring Diabetes. 63(5): 1605-11.
  • Laker R. C., Xu P., Ryall K. A., Sujkowski A., Kenwood B. M., Chain K. H., Zhang M., Royal M. A., Hoehn K. L., Driscoll M., Adler P. N., Wessells R. J., Saucerman J. J., Yan Z.. A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo J Biol Chem. 289(17): 12005-15.
  • Laker R. C., Xu P., Ryall K. A., Sujkowski A., Kenwood B. M., Chain K. H., Zhang M., Royal M. A., Hoehn K. L., Driscoll M., Adler P. N., Wessells R. J., Saucerman J. J., Yan Z.. A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo J Biol Chem. 289(17): 12005-15.
  • Larance M., Rowland A. F., Hoehn K. L., Humphreys D. T., Preiss T., Guilhaus M., James D. E.. Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3 Mol Cell Proteomics. 9(4): 682-94.
  • Larance M., Rowland A. F., Hoehn K. L., Humphreys D. T., Preiss T., Guilhaus M., James D. E.. Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3 Mol Cell Proteomics. 9(4): 682-94.
  • Lee J., Walsh M. C., Hoehn K. L., James D. E., Wherry E. J., Choi Y.. Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity J Immunol. .
  • Lee J., Walsh M. C., Hoehn K. L., James D. E., Wherry E. J., Choi Y.. Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity J Immunol. .
  • Lira V. A., Okutsu M., Zhang M., Greene N. P., Laker R. C., Breen D. S., Hoehn K. L., Yan Z.. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance FASEB J. 27(10): 4184-93.
  • Lira V. A., Okutsu M., Zhang M., Greene N. P., Laker R. C., Breen D. S., Hoehn K. L., Yan Z.. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance FASEB J. 27(10): 4184-93.
  • Modesitt S. C., Hsu J. Y., Chowbina S. R., Lawrence R. T., Hoehn K. L.. Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer Int J Gynecol Cancer. 22(5): 732-41.
  • Modesitt S. C., Hsu J. Y., Chowbina S. R., Lawrence R. T., Hoehn K. L.. Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer Int J Gynecol Cancer. 22(5): 732-41.
  • Murrow B. A., Hoehn K. L.. Mitochondrial regulation of insulin action Int J Biochem Cell Biol. 42(12): 1936-9.
  • Murrow B. A., Hoehn K. L.. Mitochondrial regulation of insulin action Int J Biochem Cell Biol. 42(12): 1936-9.
  • Park D., Han C. Z., Elliott M. R., Kinchen J. M., Trampont P. C., Das S., Collins S., Lysiak J. J., Hoehn K. L., Ravichandran K. S.. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein Nature. 477(7363): 220-4.
  • Park D., Han C. Z., Elliott M. R., Kinchen J. M., Trampont P. C., Das S., Collins S., Lysiak J. J., Hoehn K. L., Ravichandran K. S.. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein Nature. 477(7363): 220-4.
  • Patel S. A., Hoehn K. L., Lawrence R. T., Sawbridge L., Talbot N. A., Tomsig J. L., Turner N., Cooney G. J., Whitehead J. P., Kraegen E. W., Cleasby M. E.. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity Endocrinology. 153(11): 5231-46.
  • Patel S. A., Hoehn K. L., Lawrence R. T., Sawbridge L., Talbot N. A., Tomsig J. L., Turner N., Cooney G. J., Whitehead J. P., Kraegen E. W., Cleasby M. E.. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity Endocrinology. 153(11): 5231-46.
  • Richards A. A., Colgrave M. L., Zhang J., Webster J., Simpson F., Preston E., Wilks D., Hoehn K. L., Stephenson M., Macdonald G. A., Prins J. B., Cooney G. J., Xu A., Whitehead J. P.. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation Mol Endocrinol. 24(1): 229-39.
  • Richards A. A., Colgrave M. L., Zhang J., Webster J., Simpson F., Preston E., Wilks D., Hoehn K. L., Stephenson M., Macdonald G. A., Prins J. B., Cooney G. J., Xu A., Whitehead J. P.. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation Mol Endocrinol. 24(1): 229-39.
  • Stratford S., Hoehn K. L., Liu F., Summers S. A.. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B J Biol Chem. 279(35): 36608-15.
  • Stratford S., Hoehn K. L., Liu F., Summers S. A.. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B J Biol Chem. 279(35): 36608-15.
  • Taddeo E. P., Laker R. C., Breen D. S., Akhtar Y. N., Kenwood B. M., Liao J. A., Zhang M., Fazakerley D. J., Tomsig J. L., Harris T. E., Keller S. R., Chow J. D., Lynch K. R., Chokki M., Molkentin J. D., Turner N., James D. E., Yan Z., Hoehn K. L.. Opening of the Mitochondrial Permeability Transition Pore Links Mitochondrial Dysfunction to Insulin Resistance in Skeletal Muscle Molecular Metabolism. .
  • Taddeo E. P., Laker R. C., Breen D. S., Akhtar Y. N., Kenwood B. M., Liao J. A., Zhang M., Fazakerley D. J., Tomsig J. L., Harris T. E., Keller S. R., Chow J. D., Lynch K. R., Chokki M., Molkentin J. D., Turner N., James D. E., Yan Z., Hoehn K. L.. Opening of the Mitochondrial Permeability Transition Pore Links Mitochondrial Dysfunction to Insulin Resistance in Skeletal Muscle Molecular Metabolism. .
  • Turner N., Bruce C. R., Beale S. M., Hoehn K. L., So T., Rolph M. S., Cooney G. J.. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents Diabetes. 56(8): 2085-92.
  • Turner N., Bruce C. R., Beale S. M., Hoehn K. L., So T., Rolph M. S., Cooney G. J.. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents Diabetes. 56(8): 2085-92.
  • Yip M. F., Ramm G., Larance M., Hoehn K. L., Wagner M. C., Guilhaus M., James D. E.. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes Cell Metab. 8(5): 384-98.
  • Yip M. F., Ramm G., Larance M., Hoehn K. L., Wagner M. C., Guilhaus M., James D. E.. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes Cell Metab. 8(5): 384-98.